Acivicin hydrochloride
- CAS No.
- 161922-40-3
- Chemical Name:
- Acivicin hydrochloride
- Synonyms
- Acivicin hydrochloride
- CBNumber:
- CB19041490
- Molecular Formula:
- C5H8Cl2N2O3
- Molecular Weight:
- 215.03
- MDL Number:
- MFCD32874156
- MOL File:
- 161922-40-3.mol
Acivicin hydrochloride Chemical Properties,Uses,Production
Uses
Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
in vivo
Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%[3].
| Animal Model: | Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[3] |
| Dosage: | 5 mg/kg |
| Administration: | IP; twice weekly (monday and wednesday) |
| Result: | Reduced urinary γ-GT by 70-78%. |
References
[1] Kreuzer J, et al. Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem Sci. 2014 Dec 1;6(1):237-245. Epub 2014 Sep 26. DOI:10.1039/c4sc02339k
[2] Chikhale EG, et al. Carrier-mediated transport of the antitumor agent acivicin across the blood-brain barrier. Biochem Pharmacol. 1995 Mar 30;49(7):941-5. DOI:10.1016/0006-2952(95)00005-k
[3] Delphine Waniusiow, et al. Toluene-induced hearing loss in acivicin-treated rats. Neurotoxicol Teratol. May-Jun 2008;30(3):154-60. DOI:10.1016/j.ntt.2008.02.006
Acivicin hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Acivicin hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12306 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29772 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24889 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |
View Lastest Price from Acivicin hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Acivicin hydrochloride
161922-40-3
|
US $196.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Acivicin hydrochloride
161922-40-3
- US $196.00 / mg
- TargetMol Chemicals Inc.