NTRC 00660
- CAS No.
- 1817791-73-3
- Chemical Name:
- NTRC 00660
- Synonyms
- NTRC 00660;NTRC 0066 0,NTRC 00660;Pyrimido[4,5-e]indolizine-7-carboxamide, N-(2,6-diethylphenyl)-5,6-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-
- CBNumber:
- CB19631183
- Molecular Formula:
- C33H39N7O2
- Molecular Weight:
- 565.71
- MDL Number:
- MFCD30533281
- MOL File:
- 1817791-73-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
NTRC 00660 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0017983 | NTRC 0066-0 99.01% | 1817791-73-3 | 5mg | $195 | 2026-06-04 | Buy |
| ChemScene | CS-0017983 | NTRC 0066-0 99.01% | 1817791-73-3 | 10mg | $314 | 2026-06-04 | Buy |
| ChemScene | CS-0017983 | NTRC 0066-0 99.01% | 1817791-73-3 | 25mg | $628 | 2026-06-04 | Buy |
| aablocks | AA0249MC | NTRC 0066-0 >98% | 1817791-73-3 | 5mg | $235 | 2026-06-01 | Buy |
| aablocks | AA0249MC | NTRC 0066-0 >98% | 1817791-73-3 | 10mg | $358 | 2026-06-01 | Buy |
NTRC 00660 Chemical Properties, Uses, Production
Description
NTRC-0066-0 is a a highly potent and selective small molecule inhibitor of TTK. In cell lines and in mice, NTRC 0066-0 inhibits the phosphorylation of a TTK substrate and induces chromosome missegregation. NTRC 0066-0 inhibits tumor growth in MDA-MB-231 xenografts as a single agent after oral application. The combination of NTRC 0066-0 with a therapeutic dose of docetaxel resulted in doubling of mouse survival and extended tumor remission, without toxicity.
Uses
NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM). NTRC 0066-0 can be used for the research of cancer[1].
in vivo
NTRC 0066-0 inhibited tumor growth in a mouse xenograft model of the human triple-negative breast cancer (TNBC) cell line MDA-MB-231[1].
References
[1] Uitdehaag JCM, et al. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J Mol Biol. 2017;429(14):2211-2230. DOI:10.1016/j.jmb.2017.05.014
NTRC 00660 Preparation Products And Raw materials
Raw materials
Preparation Products
NTRC 00660 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd. | 15720605021 | zhang_lei@jsnchem.com | China | 1881 | 58 |
| Kaifeng Mingren Pharmaceutical Co.,LTD | 0371-65741762 | sales@hasunny.com | China | 2377 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| PharmaBlock Sciences (Nanjing), Inc. | 4000255188 | sales@pharmablock.com | China | 7266 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39007 | 58 |
