ChemicalBook >> CAS DataBase List >>N-Boc-4-piperidinemethanol

N-Boc-4-piperidinemethanol

N-Boc-4-piperidinemethanol structure

CAS No.: 123855-51-6

Chemical Name:: N-Boc-4-piperidinemethanol

Synonyms: TERT-BUTYL 4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;1-BOC-4-PIPERIDINEMETHANOL;N-BOC-piperidine-4-methanol;BOC-PIC(4)-OL;BUTTPARK 75\50-52;N-Boc-4-piperidineMe;Boc-4-Piperidine methanol;N-BOC-piperidin-4-Methanol;N-BOC-4-PIPERIDINEMETHANOL;BOC-ISONICOT(HEXAHYDRO)-OL

CBNumber:: CB2100290

Molecular Formula:: C11H21NO3

Molecular Weight:: 215.29

MDL Number:: MFCD02094488

MOL File:: 123855-51-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:53:12

Product description	Number	Pack Size	Price
N-Boc-4-piperidinemethanol 97%	556017	5g	$138
1-(tert-Butoxycarbonyl)-4-piperidinemethanol >98.0%(GC)	B2364	1g	$17
1-(tert-Butoxycarbonyl)-4-piperidinemethanol >98.0%(GC)	B2364	5g	$28
N-Boc-4-piperidinemethanol	261747	25g	$319
N-Boc-4-piperidinemethanol	261747	50g	$446
More product size

Request For Quotation

N-Boc-4-piperidinemethanol Properties

Melting point	78-82 °C (lit.)
Boiling point	308.0±15.0 °C(Predicted)
Density	1.059±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	14.94±0.10(Predicted)
form	Powder
color	White to brown
InChI	InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-9(8-13)5-7-12/h9,13H,4-8H2,1-3H3
InChIKey	CTEDVGRUGMPBHE-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(CO)CC1
CAS DataBase Reference	123855-51-6(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319

Precautionary statements

P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Safety Statements

24/25

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

13 - Non Combustible Solids

NFPA 704

	1
2		0

N-Boc-4-piperidinemethanol price More Price(92)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	556017	N-Boc-4-piperidinemethanol 97%	123855-51-6	5g	$138	2023-06-20	Buy
TCI Chemical	B2364	1-(tert-Butoxycarbonyl)-4-piperidinemethanol >98.0%(GC)	123855-51-6	1g	$17	2026-04-30	Buy
TCI Chemical	B2364	1-(tert-Butoxycarbonyl)-4-piperidinemethanol >98.0%(GC)	123855-51-6	5g	$28	2026-04-30	Buy
Usbiological	261747	N-Boc-4-piperidinemethanol	123855-51-6	25g	$319	2026-06-03	Buy
Usbiological	261747	N-Boc-4-piperidinemethanol	123855-51-6	50g	$446	2026-06-03	Buy

Product number	Packaging	Price	Buy
556017	5g	$138	Buy
B2364	1g	$17	Buy
B2364	5g	$28	Buy
261747	25g	$319	Buy
261747	50g	$446	Buy

N-Boc-4-piperidinemethanol Chemical Properties,Uses,Production

Chemical Properties

White to light brown solid

Uses

N-Boc-4-piperidinemethanol is an important piperidine derivative, which can be used in organic synthesis and pharmaceutical intermediates, It may be used to synthesize:
methyl 5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)-2-nitrobenzoate
N-Boc-4-piperidinecarboxaldehyde
[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl methanesulfonate
Involved in the synthesis of bradycardic agents.

Application

N-Boc-4-piperidinemethanol is a curcumin analogue that binds to the epidermal growth factor receptor (EGFR) and prevents the binding of ligands. In vitro studies have shown that it can inhibit tumor growth and induce apoptosis in cancer cells. The drug is also capable of inhibiting the proliferation of normal cells, which may be due to its ability to recruit EGFR from outside the cell membrane. This process triggers signaling events that lead to cell death.

General Description

N-Boc-4-piperidinemethanol contains a tert-butyloxycarbonyl (t-BOC)-protecting group. It can be synthesized from 4-piperidinemethanol via reaction with di-tert-butyldicarbonate.

Synthesis

To a dichloromethane solution ( 70 m L ) of piperidine-4-methanol ( 5.122 g , 44.5 mmol) was added di-tert-butyl dicarbonate ( 8.91 g , 40.8 mmol), the resulting reaction solution was stirred at room temperature for 3 h and then poured into Et2O ( 250 mL ), and then washed with 0.5 M aqueous HCl (3 75 mL), 50 mL of brine, separated the The organic layer was separated and dried ( MgSO4 ), the desiccant was removed by filtration and the filtrate was concentrated under vacuum to obtain the target product N-Boc-4-piperidinemethanol (9.78 g ,quantitative conversion).

N-Boc-4-piperidinemethanol synthesis

Synthesis of N-Boc-4-piperidinemethanol from Potassium carbonate and N-BOC-piperidine-4-carboxylic acid

N-Boc-4-piperidinemethanol Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL 9-OXO-3-AZASPIRO[5.5]UNDECANE-3-CARBOXYLATE 4-(TOLUENE-4-SULFONYLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-TERT-BUTOXYCARBONYL-4-(4-TOLUENESULFONYLOXYMETHYL)PIPERIDINE 1-Boc-4-(aminomethyl)piperidine tert-butyl 4-(chloromethyl)piperidine-1-carboxylate

tert-butyl 4-(4-bromophenoxymethyl)piperidine-1-carboxylate

1of2

N-Boc-4-piperidinemethanol Suppliers

Global( 473)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Yiao New Material Technology Co., Ltd	+86-18033737140 +86-17354101231	sales1@hbganmiao.com	China	227	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	20582	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21587	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
Shanxi Naipu Import and Export Co.,Ltd	+86-13734021967 +8613734021967	kaia@neputrading.com	China	1001	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Zhengzhou Yuanli Biological Technology Co., Ltd	0086-371-67897895 18903711767	sales02@zzyuanli.cn	CHINA	149	58

Supplier	Advantage
Anhui Yiao New Material Technology Co., Ltd	58
Dideu Industries Group Limited	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Anqing Chico Pharmaceutical Co., Ltd.	58
Shanxi Naipu Import and Export Co.,Ltd	58
career henan chemical co	58
Zhengzhou Yuanli Biological Technology Co., Ltd	58

View Lastest Price from N-Boc-4-piperidinemethanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	N-Boc-4-piperidinemethanol 123855-51-6	$1.10	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2024-06-11	N-(tert-Butoxycarbonyl)-4-piperidinemethanol 123855-51-6		1kg	99%	100 tons	Anhui Yiao New Material Technology Co., Ltd
2024-06-11	N-(tert-Butoxycarbonyl)-4-piperidinemethanol 123855-51-6		1kg	99%	100 tons	Anhui Yiao New Material Technology Co., Ltd

N-Boc-4-piperidinemethanol
123855-51-6
$1.10
99.0% Min
Dideu Industries Group Limited

N-(tert-Butoxycarbonyl)-4-piperidinemethanol
123855-51-6
$0.00
99%
Anhui Yiao New Material Technology Co., Ltd

N-(tert-Butoxycarbonyl)-4-piperidinemethanol
123855-51-6
$0.00
99%
Anhui Yiao New Material Technology Co., Ltd

N-Boc-4-piperidinemethanol Spectrum

N-Boc-4-piperidinemethanol(123855-51-6)¹HNMR N-Boc-4-piperidinemethanol(123855-51-6)IR

123855-51-6(N-Boc-4-piperidinemethanol)Related Search:

N-Boc-Piperidine-4-carboxylic acid methyl ester DROPERIDOL N-(tert-Butoxycarbonyl)-4-piperidone Haloperidol PHENCYCLIDINE-D5 HYDROCHLORIDE

tert-Butyl acetate tert-Butyl peroxyacetate 4-Piperidinemethanol 1-Boc-2-piperidinemethanol,1-N-Boc-2-piperidinemethanol,1-TERT-BUTOXYCARBONYL-2-PIPERIDINEMETHANOL, N-BOC-2-PIPERIDINEMETHANOL 1-TERT-BUTOXYCARBONYL-3-PIPERIDINEMETHANOL, N-BOC-3-PIPERIDINEMETHANOL,1-Boc-3-piperidinemethanol

1-Boc-4-(2-hydroxyethyl)piperidine 2,2,6,6-Tetramethyl-4-piperidinol tert-Butanol N-BOC-4-Hydroxypiperidine tert-Butyl 4-methylenepiperidine-1-carboxylate

1-Boc-4-cyanopiperidine N-Boc-(2R,3R,4S)-dolaproine TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE

1of4

1-N-BOC-4-HYDROXYMETHYL-PIPERIDINE 1-(TERT-BUTOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE 1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEMETHANOL TERT-BUTYL 4-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE N-T-BUTOXYCARBONYL-HEXAHYDROISONICOTINOL N-T-BUTOXYCARBONYL-4-HYDROXYMETHYL-PIPERIDINE N-T-BUTOXYCARBONYL-4-PIPECOLINOL N-T-BUTOXYCARBONYL-4-PIPERIDINEMETHANOL N-(TERT-BUTOXYCARBONYL)-4-(HYDROXYMETHYL)PIPERIDINE N-(TERT-BUTOXYCARBONYL)-4-PIPERIDINEMETHANOL 1-Boc-4-(hydroxymethyl)piperidine 1-Boc-4-piperidinemethanol 1-(tert-Butoxycarbonyl)-4-(hydroxymethyl)piperidine N-Boc-4-piperidineMe N-BOC-piperidine-4-methanol 1-piperidinecarboxylic acid, 4-(hydroxymethyl)-, 1,1-dimet N-Boc-4-piperidinemethanol ,97% N-Boc-4-piperidinemethanol,N-tert-Butyloxycarbonyl-4-piperidinemethanol 4-(Hydroxymethyl)piperidine, N-BOC protected 97% 1-Boc-4-(hydroxymethyl)-p... tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4-(hydroxymethyl)piperidine t-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate tert-butyl 4-(hydroxyMethyl)piperidin-1-carboxylate N-BOC-piperidin-4-Methanol N-Boc-4-piperidineMethanol, 95+% N - bok - 4 - piperidine Methanol 1-Boc-4-piperidinemethanol Synonyms N-tert-Butyloxycarbonyl-4-piperidinemethanol N-Boc-4-piperidinemethanol 97% 1,1-Dimethylethyl 4-(hydroxymethyl)-1-piperidinecarboxylate n-tert-butyloxycarbonyl-4-piperidinemethanol N-BOC-4-HYDROXYLMETHYLENE-PIPERIDINE N-BOC-4-HYDROXYMETHYLPIPERIDINE N-BOC-4-PIPERIDINEMETHANOL 1-N-Boc-4-piperidinemethanol tert-Butyl 4-(hydroxymethyl)-1-piperidinecarboxylate 1-(TERT-BUTOXYCARBONYL)-4-PYRROLIDINEMETHANOL (1-Boc-Piperidin-4-yl)methanol 1-TERT-BUTOXYCARBONYL-4-PIPERIDINEMETHANOL, N-BOC-4-PIPERIDINEMETHANOL N-BOC-4-HYDROXYMETHYLPIPERDINE N-(tert-Butoxycarbonyl)-4-(Hydroxymethyl)piperidine, 98 % 1-Piperidinecarboxylic acid, 4-(hydroxymethyl)-, 1,1-dimethylethyl ester 1-Boc-4-Hyroxymethyl-Piperidine 4-Hydroxylmethyl-N-( tert-butylcarboxylate)piperidine BUTTPARK 75\50-52 BOC-PIC(4)-OL BOC-ISONICOT(HEXAHYDRO)-OL 4-HYDROXYMETHYL-1-TERT-BUTOXYCARBONYLPIPERIDINE 4-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(HYDROXYMETHYL)PIPERIDINE-N-BOC PROTECTED 1-BOC-4-(HYDROXYMETHYL)PIPERIDINE tert-Butyl 4-(hydroxymethyl)-1 1-(tert-Butoxycarbonyl)-4-piperidinemethanol > Boc-4-Piperidine methanol N-Boc-4-piperidinyl alcohol N-Boc 4-piperdine methanol N-Boc-4-piperidinemethanol 123855-51-6 4-Hydroxymethyl-piperidin-1-carboxylic acid tert-butyl ester N-Boc-4-piperidinemethanol N-Boc-4-piperidinecarbinol 1-BOC-4-PIPERIDINEMETHANOL