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ChemicalBook >> CAS DataBase List >>Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-

Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-

Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- Structure
Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- structure
CAS No.
1616271-41-0
Chemical Name:
Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-
Synonyms
CCTA-1523;CCTA 1523,CCTA1523;CCTA-1523, 10 mM in DMSO;Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-
CBNumber:
CB210148648
Molecular Formula:
C16H15Cl2NO3
Molecular Weight:
340.2
MDL Number:
MOL File:
1616271-41-0.mol
Last updated:2025-04-18 09:51:48
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Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- Properties

Boiling point 498.5±45.0 °C(Predicted)
Density 1.313±0.06 g/cm3(Predicted)
pka 11.00±0.70(Predicted)

Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- Chemical Properties,Uses,Production

Description

CCTA-1523 is an inhibitor of the efflux function of ABCG2. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells, both in vitro and in vivo.

Uses

CCTA-1523 is a potent, selective, reversible and orally active ABCG2 inhibitor. CCTA-1523 shows cytotoxicity. CCTA-1523 shows anticancer activity[1].

in vivo

CCTA-1523 (75 mg/kg; p.o.; q3d x 6) combined with doxorubicin (HY-15142A) (1.8 mg/kg, i.p., q3d X 6) inhibits tumor growth and increases the survival time in mice[1].

Animal Model:NCR nude mice (H460/MX20 xenografts)[1]
Dosage:75 mg/kg (DOX ;1.8 mg/kg, i.p., q3d X 6)
Administration:P.o.;q3d x 6
Result:Significantly inhibited the growth of H460/MX20 tumor xenografts when combined with doxorubicin compared to the vehicle control group.

References

[1] Patel A,et al. Suppression of ABCG2 mediated MDR in vitro and in vivo by a novel inhibitor of ABCG2 drug transport. Pharmacol Res. 2017 Jul;121:184-193. DOI:10.1016/j.phrs.2017.04.025

Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38663 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 sales@szzxbio.com China 2978 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19965 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 55710 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
BOC Sciences 65
Suzhou Zhixin Biotechnology Co., Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Sangon Biotech (Shanghai) Co.,Ltd. 58

View Lastest Price from Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CCTA-1523 pictures 2024-11-19 CCTA-1523
1616271-41-0
 US $89.00-298.00 / mg 99.03% 10g TargetMol Chemicals Inc.
  • CCTA-1523 pictures
  • CCTA-1523
    1616271-41-0
  • US $89.00-298.00 / mg
  • 99.03%
  • TargetMol Chemicals Inc.

Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- Spectrum

Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)-(1616271-41-0)1HNMR
Acetamide, 2,2-dichloro-N-(3',4'-dimethoxy[1,1'-biphenyl]-3-yl)- CCTA-1523 CCTA 1523,CCTA1523 CCTA-1523, 10 mM in DMSO 1616271-41-0