HOLO-TRANSFERRIN | 11096-37-0

HOLO-TRANSFERRIN Properties

storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
color	Brown to reddish brown
biological source	synthetic
Water Solubility	Soluble in water (50 mg/ml).
InChIKey	XNSAINXGIQZQOO-WRBUEIFXNA-N
SMILES	N1C(=O)CC[C@H]1C(NC(CC1NC=NC=1)C(N1CCC[C@H]1C(=O)N)=O)=O \|&1:5,20,r\|
CAS DataBase Reference	11096-37-0
EPA Substance Registry System	Transferrin (11096-37-0)
UNSPSC Code	41106213
NACRES	NA.83

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P280-P264
Hazard Codes	B,Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3
F	21
TSCA	TSCA listed
HS Code	3002120000
Storage Class	11 - Combustible Solids

HOLO-TRANSFERRIN price More Price(93)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T3915	Transferrin-biotin labeled human lyophilized powder containing sodium citrate	11096-37-0	5MG	$240	2026-04-30	Buy
Sigma-Aldrich	T3705	Transferrin human recombinant, expressed in rice	11096-37-0	1G	$698	2026-04-30	Buy
Sigma-Aldrich	T3705	Transferrin human recombinant, expressed in rice	11096-37-0	5G	$3250	2026-04-30	Buy
Sigma-Aldrich	T1428	apo-Transferrin bovine BioReagent, suitable for cell culture, ≥98%	11096-37-0	50MG	$119	2026-04-30	Buy
Sigma-Aldrich	T1428	apo-Transferrin bovine BioReagent, suitable for cell culture, ≥98%	11096-37-0	100MG	$173	2026-04-30	Buy

Product number	Packaging	Price	Buy
T3915	5MG	$240	Buy
T3705	1G	$698	Buy
T3705	5G	$3250	Buy
T1428	50MG	$119	Buy
T1428	100MG	$173	Buy

HOLO-TRANSFERRIN Chemical Properties,Uses,Production

Description

Holo-transferrin is the transferrin of the holo iron. It is a kind of iron-binding blood plasmaglycoproteins that is capable of regulating the level of free iron (Fe) in biological fluids. It is responsible for iron transportation in vertebrate serum and donating irons to cells through interaction with the CD71 membrane receptor. Transferrin is crucial for proliferating cells as a growth factor to initiate and maintain the DNA synthesis. It can also act as a cytokine. It is mainly synthesized in liver inside the human body. It is responsible to deliver iron from duodenum and white blood cells macrophages to all the other tissues, and is a key protein to maintain in vivo iron homeostasis. Increased plasma transferrin level is related to diseases such as iron deficiency anemia while decrease plasma transferrin is related to iron overload diseases and protein malnutrition.

Uses

Transferrin is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. Transferrin is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. Human holo-transferrin is a high affinity transferrin that can be used with a wide range of cells types. Human holo-transferrin is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media.

Uses

All cells require iron for the proper uptake of oxygen from their environment. Transferrin, a protein isolated from serum, causes the uptake and transport of iron from culture medium to the cells. This allows proper oxygen uptake and also stimulates growth-related enzyme activity. Iron-saturated transferrin (holo transferrin) is continually recycled after releasing iron and becomes iron-deficient transferrin (apo-transferrin). Choosing which form to use depends upon the culture conditions. In media such as Dulbecco′s Modified Eagle′s Medium/Ham′s Nutrient Mixture F12 (DMEM/F12) that contain high levels of iron salt, using apo-transferrin is preferred.

Uses

Transferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

Definition

ChEBI: Protirelin is a tripeptide composed of L-pyroglutamyl, L-histidyl and L-prolinamide residues joined in sequence. It has a role as a human metabolite. It is a peptide hormone and a tripeptide.

General Description

Transferrin is an 80 kDa serum glycoprotein, which has an half-life of 8 to 10 days. The gene is located on human chromosome 3q22.1. Transferrin is expressed in hepatocytes.

Pharmaceutical Applications

Transferrins are a group of proteins that are abundant in blood and their primary role is to transport Fe3+, as free Fe3+ would be toxic to most organisms. Transferrin consists of a single polypeptide chain independently binding a maximum of two Fe3+ ions. Fe3+ is bound in a hexa-coordinated high-spin complex within the protein. The metal is coordinated by the N atom from the imidazole residue, two deprotonated phenol groups, a carboxylate and a carbonato ligand.

Biochem/physiol Actions

Studies have shown that co-treatment of breast cancer cells with holo-transferrin, which increases iron levels within cells and derivatives of artemisinin results in increased cell death.

Purification Methods

This transferrin is purified by affinity chromatography on phenyl-boronate agarose followed by DEAE-Sephacel chromatography. The product is free from haemopexin. [Cook et al. Anal Biochem 149 349 1985, Aisen & Listowsky Ann Rev Biochem 49 357 1980.]

Description

Recombinant Human Transferrin produced in Plant is a non-glycosylated, polypeptide chain containing 679 amino acids and having a molecular mass of 76 kDa.
The Recombinant Human Transferrin is purified by proprietary chromatographic techniques.

Source

Oryza sativa

Background

Transferrin is the iron-transport protein of vertebrate serum and donates iron to cells through interaction with a specific membrane receptor, CD71. Transferrin appears to be indispensable for most cells growing in tissue culture.
It is referred to frequently as a growth factor because, in analogy to other growth factor-receptor interactions, proliferating cells express high numbers of transferrin receptors, and the binding of transferrin to their receptors is needed for cells to initiate and maintain their DNA synthesis. Apart from its role as an iron transport protein transferrin acts as a cytokine and has functions that may not be related to its iron-carrying capacity.

References

https://en.wikipedia.org/wiki/Transferrin
http://www.prospecbio.com/Holo_Transferrin_Human_11_121/

HOLO-TRANSFERRIN Preparation Products And Raw materials

Raw materials

Preparation Products

HOLO-TRANSFERRIN Suppliers

Global( 343)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Baoman Biotechnology Co., Ltd.	021-62130998	baomanbio@163.com	China	199	55
Lingyuan Bebiansen Biological Technology Co., Ltd	18642120371	2837458851@qq.com	China	7961	58
Hu' nan Yunbang Pharmaceutical Co., Ltd.	88532689 15386497078	yunbang@yunbangapi.com	China	6935	58
Hunan Yongqi Chemical Co., LTD	0731-85561035 13319583233	yongqi@yongqichem.com	China	681	58
Shanghai Yingxin laboratory equipment Co., Ltd	021-021-59178156 15300768757	359382369@qq.com	China	10667	58
Hunan Wokai Biotechnology Co., Ltd.	0744-2221508 13126795102	2577930172@qq.com	China	315	58
Fuan Bio	15002819872	2845971812@qq.com	China	2103	58
Nanjing Dulai Biotechnology Co., Ltd.	025-84699383-8003;025-846993838003-8003 18013301590	njduly@126.com	China	3293	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69

Supplier	Advantage
Shanghai Baoman Biotechnology Co., Ltd.	55
Lingyuan Bebiansen Biological Technology Co., Ltd	58
Hu' nan Yunbang Pharmaceutical Co., Ltd.	58
Hunan Yongqi Chemical Co., LTD	58
Shanghai Yingxin laboratory equipment Co., Ltd	58
Hunan Wokai Biotechnology Co., Ltd.	58
Fuan Bio	58
Nanjing Dulai Biotechnology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69

View Lastest Price from HOLO-TRANSFERRIN manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	HOLO-TRANSFERRIN 11096-37-0		1g	99%	500g	WUHAN FORTUNA CHEMICAL CO., LTD
2026-08-07	Transferrin 11096-37-0		100G	98	1KG	Shaanxi Dideu Medichem Co. Ltd
2026-07-27	Transferrins 11096-37-0	$40.00-89.00			10g	TargetMol Chemicals Inc.

HOLO-TRANSFERRIN
11096-37-0
$0.00
99%
WUHAN FORTUNA CHEMICAL CO., LTD

Transferrin
11096-37-0
98
Shaanxi Dideu Medichem Co. Ltd

Transferrins
11096-37-0
$40.00-89.00
TargetMol Chemicals Inc.

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