3-(Methylsulfonyl)benzenesulfonylchloride
- CAS No.
- 5335-40-0
- Chemical Name:
- 3-(Methylsulfonyl)benzenesulfonylchloride
- Synonyms
- 3-mesylbenzenesulfonyl chloride;3-Methanesulfonylbenzenesulfonyl chloride;3-(Chlorosulphonyl)phenyl methyl sulphone;Benzenesulfonyl chloride, 3-(methylsulfonyl)-;3-(Methylsulfonyl)benzene-1-sulfonyl chloride
- CBNumber:
- CB21096497
- Molecular Formula:
- C7H7ClO4S2
- Molecular Weight:
- 254.71
- MDL Number:
- MFCD04037968
- MOL File:
- 5335-40-0.mol
- MSDS File:
- SDS
| Melting point | 93~96℃ |
|---|---|
| Boiling point | 449.7±37.0 °C(Predicted) |
| Density | 1.517±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | crystalline solid |
| color | White to off white |
| CAS DataBase Reference | 5335-40-0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H330-H301-H314-H290 |
| Precautionary statements | P501-P260-P270-P234-P271-P264-P280-P284-P390-P303+P361+P353-P301+P330+P331-P363-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P406-P405 |
| RIDADR | UN3261 |
| HazardClass | 8 |
| HS Code | 2904990090 |
| Limited Quantities | 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
3-(Methylsulfonyl)benzenesulfonylchloride price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FAA33540 | 3-(Methylsulfonyl)benzenesulfonyl Chloride | 5335-40-0 | 0.25g | $250 | 2026-06-04 | Buy |
| Biosynth | FAA33540 | 3-(Methylsulfonyl)benzenesulfonyl Chloride | 5335-40-0 | 2.5g | $855.5 | 2026-06-04 | Buy |
| Apolloscientific | OR7993 | 3-(Methylsulphonyl)benzenesulphonyl chloride 95% | 5335-40-0 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR7993 | 3-(Methylsulphonyl)benzenesulphonyl chloride 95% | 5335-40-0 | 5g | $43 | 2026-06-04 | Buy |
| Apolloscientific | OR7993 | 3-(Methylsulphonyl)benzenesulphonyl chloride 95% | 5335-40-0 | 25g | $172 | 2026-06-04 | Buy |
3-(Methylsulfonyl)benzenesulfonylchloride Chemical Properties, Uses, Production
Synthesis
3112-85-4
5335-40-0
The general procedure for the synthesis of 3-methylsulfonylbenzenesulfonyl chloride from phenylmethylsulfone was as follows: the intermediate 3-methylsulfonylbenzene-1-sulfonyl chloride was synthesized with reference to the method reported by Park et al. in J. Med. Chem. 2007, 51(21):6902-6915. The operation was as follows: methylsulfonylbenzene (110 g, 0.7 mol) was mixed with chlorosulfonic acid (450 mL, 6.7 mol), and the reaction was heated at 90 °C for 18 hours. Upon completion of the reaction, the reaction mixture was cooled to about 21 °C and subsequently slowly poured onto crushed ice. The resulting slurry was extracted twice with EtOAc (2 L each). The organic phases were combined, washed with brine (50 mL) and subsequently dried over sodium sulfate, filtered and concentrated under reduced pressure to give the intermediate sulfonyl chloride (125 g, 75% yield) as an off-white solid. The product was characterized by 1H NMR (400 MHz, CDCl3) with the following chemical shifts: δ 8.61 (1H, t, J = 1.7 Hz), 8.35-8.31 (2H, m), 7.90 (1H, t, J = 7.9 Hz), 3.15 (3H, s).
References
[1] Patent: US2014/206769, 2014, A1. Location in patent: Paragraph 0146
[2] Patent: EP3348548, 2018, A1. Location in patent: Paragraph 0103
3-(Methylsulfonyl)benzenesulfonylchloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
