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ChemicalBook >> CAS DataBase List >>Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl-

Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl-

Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl- Structure
Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl- structure
CAS No.
681511-84-2
Chemical Name:
Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl-
Synonyms
SLW131;Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl-
CBNumber:
CB211129659
Molecular Formula:
C21H27N5O5S
Molecular Weight:
461.53
MDL Number:
MOL File:
681511-84-2.mol
Last updated:2025-04-18 09:51:47
Request For Quotation

Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl- Properties

Boiling point 592.6±60.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
pka 7.42±0.50(Predicted)

Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl- Chemical Properties, Uses, Production

Uses

SLW131 (Compound 10) is the antagonist for CCR7 with a good affinity of Ki of 9.85 nM. SLW131 inhibits CCL19-induced Go protein activation with an IC50 of 29.4 μM, inhibits β-arrestin2 recruitment with an IC50 of 6.0 μM. SLW131 inhibits CCL19-induced cell morphological changes in primary BMDCs, and CCR7-mediated migration in mouse CD4+ T cell[1].

References

[1] Wurnig SL, et al., A Fluorescent Probe Enables the Discovery of Improved Antagonists Targeting the Intracellular Allosteric Site of the Chemokine Receptor CCR7. J Med Chem. 2025 Feb 27;68(4):4308-4333. DOI:10.1021/acs.jmedchem.4c02102

Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl- Preparation Products And Raw materials

Raw materials

Preparation Products

Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl- Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
TargetMol 58

681511-84-2 (Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl-) Related Search:

BCA-1/CXCL13 Protein, MOUSE (HEK293, HIS) MIP-3 beta/CCL19 Protein, Mouse RANTES/CCL5 Protein, Human BL-8040 9-Azabicyclo[3.3.1]nonane-9-acetamide, N-(2-chlorophenyl)-3-[(3,4,5-trimethoxybenzoyl)amino]-, (3-exo)-
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Benzamide, 3-[[4-[[(1R)-2,2-dimethyl-1-(5-methyl-2-furanyl)propyl]amino]-1,1-dioxido-1,2,5-thiadiazol-3-yl]amino]-2-hydroxy-N,N-dimethyl- SLW131 681511-84-2