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Vatalanib Dihydrochloride

Vatalanib Dihydrochloride Structure
Vatalanib Dihydrochloride structure
CAS No.
212141-51-0
Chemical Name:
Vatalanib Dihydrochloride
Synonyms
PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl
CBNumber:
CB21176854
Molecular Formula:
C20H17Cl3N4
Molecular Weight:
419.74
MDL Number:
MFCD08458964
MOL File:
212141-51-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-28 08:54:30
Product description Number Pack Size Price
Vatalanib dihydrochloride ≥98% (HPLC) SML2498 10mg $83.7
Vatalanib dihydrochloride ≥98% (HPLC) SML2498 50mg $283
Vatalanib (hydrochloride) ≥98% 14868 10mg $57
Vatalanib (hydrochloride) ≥98% 14868 25mg $120
Vatalanib (hydrochloride) ≥98% 14868 50mg $182
More product size
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Vatalanib Dihydrochloride Properties

Melting point 268-2700C
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
form solid
color White or off-white
Water Solubility H2O: 2mg/mL, clear
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
InChI 1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
InChIKey AZUQEHCMDUSRLH-UHFFFAOYSA-N
SMILES ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42
CAS DataBase Reference 212141-51-0
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P280
Risk Statements  36/37/38
Safety Statements  24/25
WGK Germany  WGK 3
HS Code  29333990
Storage Class 11 - Combustible Solids

Vatalanib Dihydrochloride price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2498 Vatalanib dihydrochloride ≥98% (HPLC) 212141-51-0 10mg $83.7 2026-04-30 Buy
Sigma-Aldrich SML2498 Vatalanib dihydrochloride ≥98% (HPLC) 212141-51-0 50mg $283 2026-04-30 Buy
Cayman Chemical 14868 Vatalanib (hydrochloride) ≥98% 212141-51-0 10mg $57 2026-04-30 Buy
Cayman Chemical 14868 Vatalanib (hydrochloride) ≥98% 212141-51-0 25mg $120 2026-04-30 Buy
Cayman Chemical 14868 Vatalanib (hydrochloride) ≥98% 212141-51-0 50mg $182 2026-04-30 Buy
Product number Packaging Price Buy
SML2498 10mg $83.7 Buy
SML2498 50mg $283 Buy
14868 10mg $57 Buy
14868 25mg $120 Buy
14868 50mg $182 Buy

Vatalanib Dihydrochloride Chemical Properties,Uses,Production

Description

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Chemical Properties

White to Off-White Crystalline Powder

Uses

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.

Uses

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

in vivo

Vatalanib induces dose-dependent inhibition of the angiogenic response to VEGF and PDGF in both a growth factor implant model and a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg). In the same dose range, Vatalanib also inhibits the growth and metastasesof several human carcinomas in nude mice without significant effect on circulating blood cells or bone marrow leukocytes[1].

IC 50

VEGFR2: 37 nM (IC50)

References

[1] J M WOOD. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.[J]. Cancer research, 2000, 60 8: 2178-2189.
[2] ANDERSON K. The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment[J]. European Journal of Haematology, 2008, 70 4: 266-267. DOI:10.1034/j.1600-0609.2003.t01-1-01067.x

Vatalanib Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Vatalanib Dihydrochloride Suppliers

Global( 162)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29819 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 18895 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52705 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
PT CHEM GROUP LIMITED 		+86-85511178; peter68@ptchemgroup.com China 35425 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
Dideu Industries Group Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
PT CHEM GROUP LIMITED 		58

View Lastest Price from Vatalanib Dihydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vatalanib dihydrochloride pictures 2026-04-27 Vatalanib dihydrochloride
212141-51-0
 US $40.00-64.00 / mg 99.78% 10g TargetMol Chemicals Inc.
Vatalanib Dihydrochloride pictures 2025-12-01 Vatalanib Dihydrochloride
212141-51-0
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
Vatalanib Dihydrochloride pictures 2019-07-06 Vatalanib Dihydrochloride
212141-51-0
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co

Vatalanib Dihydrochloride Spectrum

Vatalanib Dihydrochloride(212141-51-0)1HNMR

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Dihydrochloride Vatalanib succinate Vatalanib Dihydrochloride

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CGP-79787 Dihydrochlorid N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Dihydrochloride Vatalanib Dihydrochloride CGP-79787 Dihydrochloride Vatalanib 2hcl((ZK-222584,PTK 787) Vatalanib dihydrochloride (PTK787) CGP-79787 CGP-79787D PTK/ZK ZK-222584 CGP-79787, PTK 787, ZK222584 N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride ZK 222584 (cpg-79787) 2HCl Vatalanib 2HCl (PTK787) Vatalanib (PTK787) 2HCl Vatalanib (hydrochloride) Vatalanib dihydrochloride(2HCL) Vatalanib (PTK787) diHydrochloride CS-465 ZK-222584 dihydrochloride CGP-797870 dihydrochloride PTK787 dihydrochloride Vatalanib Dihydrochloride USP/EP/BP 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2) CGP79787) 2HCl Vatalinib 2HCl Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor Vatalanib dihydrochloride, 10 mM in DMSO Vatalanib dihydrochloride/212141-51-0/98% 212141-51-0 C20H17Cl3N4 C20H15ClN42HCl C20H15Cl2N42HCl C20H15ClN42ClH Heterocycles Tyrosine Kinase Inhibitors Antineoplastic Intermediates & Fine Chemicals Pharmaceuticals Inhibitors