ChemicalBook >> CAS DataBase List >>Sodium levothyroxine pentahydrate

Sodium levothyroxine pentahydrate

Sodium levothyroxine pentahydrate structure

CAS No.: 6106-07-6

Chemical Name:: Sodium levothyroxine pentahydrate

Synonyms: L-THYROXINE SODIUM SALT PENTAHYDRATE;lt,pentahydrate,;L-THYROXINE SODIUM PENTAHYDRATE;SODIUM L-THYROXINE PENTAHYDRATE;SODIUM LEVOTHYROXINE PENTAHYDRATE;Sodium levothyroxine pentahydrate 98%;L-Thyroxine sodium pentahydrate USP27;L-Thyroxine pentahydrate sodium salt;L-Thyroxine sodiuM salt pentahydD23-Rate;L-THYROXINE, SODIUM SALT PENTAHYDRATE, 9 9%

CBNumber:: CB2123792

Molecular Formula:: C15H20I4NNaO9

Molecular Weight:: 888.93

MDL Number:: MFCD00149110

MOL File:: 6106-07-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 23:55:04

Request For Quotation

Sodium levothyroxine pentahydrate Properties

Melting point	207-210 (dec.)(lit.)
alpha	[α]D20 +15～+19°
Density	2.381
storage temp.	2-8°C
solubility	cell culture medium: 0.1 mg/mL
form	powder
color	White to Yellow to Orange
biological source	synthetic (organic)
BRN	5721845
InChIKey	JMHCCAYJTTWMCX-QWPJCUCISA-M
SMILES	O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
CAS DataBase Reference	6106-07-6(CAS DataBase Reference)
FDA UNII	9J765S329G
UNSPSC Code	51111800
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H372
Precautionary statements	P260-P264-P270-P314-P501
target organs	Thyroid,Cardio-vascular system,Kidney
PPE	Eyeshields, Gloves, type N95 (US)
Hazard Codes	Xn
Risk Statements	40
Safety Statements	22-24/25-36
WGK Germany	3
RTECS	YP2833760
F	3-8-10
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	STOT RE 1

Sodium levothyroxine pentahydrate price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T2501	L-Thyroxine sodium salt pentahydrate ≥98% (HPLC), powder	6106-07-6	1G	$196	2026-04-30	Buy
Sigma-Aldrich	T2501	L-Thyroxine sodium salt pentahydrate ≥98% (HPLC), powder	6106-07-6	5G	$786	2026-04-30	Buy
Sigma-Aldrich	T0397	L-Thyroxine sodium salt pentahydrate γ-irradiated, powder, BioXtra, suitable for cell culture	6106-07-6	1MG	$71.4	2026-04-30	Buy
TCI Chemical	T0245	L-Thyroxine Sodium Salt Pentahydrate	6106-07-6	100MG	$36	2026-04-30	Buy
TCI Chemical	T0245	L-Thyroxine Sodium Salt Pentahydrate	6106-07-6	1G	$103	2026-04-30	Buy

Product number	Packaging	Price	Buy
T2501	1G	$196	Buy
T2501	5G	$786	Buy
T0397	1MG	$71.4	Buy
T0245	100MG	$36	Buy
T0245	1G	$103	Buy

Sodium levothyroxine pentahydrate Chemical Properties, Uses, Production

Uses

L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].

Hazard

A reproductive hazard.

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

in vivo

Deiodinases (DIOs), which catalyse the conversion of thyroxine (pro-hormone) to the active thyroid hormone, are associated with thyroid stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play pivotal role in the negative feedback regulation of pituitary TSH secretion^[1]. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19). Rats treated with high doses of L-Thyroxine display a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03)^[2].

IC 50

Human Endogenous Metabolite

Purification Methods

Crystallise the sodium salt from absolute EtOH and dry it for 8hours at 30o/1mm. [Canepa Acta Cryst 4 283 1951, Beilstein 14 II 378, 14 III 1566, 14 IV 2374.]

References

[1] Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323. DOI:10.1507/endocrj.EJ17-0162
[2] Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149. DOI:10.1016/j.jcte.2014.09.005

Sodium levothyroxine pentahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Sodium levothyroxine pentahydrate Suppliers

Global Suppliers ( 123)

Supplier	Tel	Email	Country	ProdList	Advantage
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58
TOKYO CHEMICAL INDUSTRY CO., LTD.	03-36680489	Sales-JP@TCIchemicals.com	Japan	28364	80
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Shanghai BeiZhuo Biotech Co., Ltd.	021-61119791,13386096464	bzswkf@foxmail.com	China	3916	50
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185 18149758185	sales-cpd@caerulumpharma.com	China	3493	58
ShangHai D&B Biological Science and Technology Co.Ltd	400-008-9730,021-54359730 400-008-9730	info@chemxyz.com	China	3642	60
Hangzhou J&H Chemical Co., Ltd.	0571-87396432	sales@jhechem.com	China	14905	59
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80

Supplier	Advantage
Syntechem Co.,Ltd	57
Tianjin heowns Biochemical Technology Co., Ltd.	57
Dalian Meilun Biotech Co., Ltd.	58
TOKYO CHEMICAL INDUSTRY CO., LTD.	80
MedChemexpress LLC	58
Shanghai BeiZhuo Biotech Co., Ltd.	50
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
ShangHai D&B Biological Science and Technology Co.Ltd	60
Hangzhou J&H Chemical Co., Ltd.	59
Sigma-Aldrich	80

View Latest Price from Sodium levothyroxine pentahydrate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-17	Sodium Levothyroxine Pentahydrate 6106-07-6		1g	More Than 99%	100kg/Month	BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
	2020-01-05	Sodium levothyroxine pentahydrate 6106-07-6	$1.00	1KG	95-99%	1ton	Career Henan Chemical Co

Sodium Levothyroxine Pentahydrate
6106-07-6
$0.00
More Than 99%
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Sodium levothyroxine pentahydrate
6106-07-6
$1.00
95-99%
Career Henan Chemical Co

Sodium levothyroxine pentahydrate Spectrum

Sodium levothyroxine pentahydrate(6106-07-6)¹HNMR Sodium levothyroxine pentahydrate(6106-07-6)IR Sodium levothyroxine pentahydrate(6106-07-6)Raman Sodium levothyroxine pentahydrate(6106-07-6)FT-IR

6106-07-6 (Sodium levothyroxine pentahydrate) Related Search:

Sodium levothyroxine Diclofenac sodium Sodium hydroxide Sodium bicarbonate Sodium acetate

L-Tyrosine TSH 3,3',5-Triiodo-L-thyronine Citrazinic acid Boc-D-Tyr-OH

Inositol Sodium benzoate DL-THYROXINE Trisodium phosphate Sodium tetraborate pentahydrate

Levothyroxine Chlorophosphonazo III H-Arg-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr-Thr-Ala-Arg-Gly-OH

1of4

3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE SODIUM SALT PENTAHYDRATE 3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]-L-ALANINE PENTAHYDRATE 3,3',5,5'-TETRAIODO-L-THYRONINE SODIUM SALT PENTAHYDRATE (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONIC ACID SODIUM SALT PENTAHYDRATE SODIUM (S)-2-AMINO-3-[4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODOPHENYL]PROPIONATE PENTAHYDRATE SODIUM LEVOTHYROXINE PENTAHYDRATE 3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)-alaninmonosodiumsa lt,pentahydrate, L-THYROXINE SODIUM PENTAHYDRATE l-tyrosine,o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-,sodiumsalt,pentahydra o-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-l-tyrosinesodiumsaltpentahydrate L-thyroxine sodium pentahydrate*gamma-irradiated sodium L-4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodobenzylalaninate pentahydrate L-THYROXINE, SODIUM SALT PENTAHYDRATE, 9 9% L-THYROXINE SODIUM PENTAHYDRATE*GAMMA-IR RADIATED CE L-Thyroxinesodiumsaltpentahydratecrystalline 3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-l-alanine sodium salt O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine monosodium salt pentahydrate L-Thyroxine pentahydrate sodium salt Sodium levothyroxine, T4, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt SODIUM L-THYROXINE PENTAHYDRATE 0-( 4-HYDROXY-3,5-DIIDOPHENYL)-N-ACEYTL)-3,5-DIIODO-L-TYROSINE ETHYL ESTER sodiuM (S)-2-aMino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)propanoate pentahydrate L-Thyroxine sodiuM salt pentahydD23-Rate Sodium levothyroxine pentahydrate 98% L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine) L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt, hydrate (1:1:5) L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine pentahydrate) sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)- 3,5-diiodophenyl]propanoate pentahydrate L-Thyroxine sodium salt pentahydrate (Sodium levothyroxine), thyroid prohormone (T4) L-Thyroxine sodium salt pentahydrate L-Thyroxine sodium pentahydrate USP27 L-THYROXINE SODIUM SALT PENTAHYDRATE 6106-07-6 HOC6H2I2OC6H2I2CH2CHNH2COONa5H2O C15H10O4NI4Nax5H2O C15H10I4NO4Na5H2O C15H20I4NNaO9 Cytokines, Growth Factors and Hormones Other Protein/Peptide Hormones Hormones Thyroxine (T4) Cell Signaling and Neuroscience Cell Biology BioChemical Hormones