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Vanillylidenacetone

Vanillylidenacetone structure

CAS No.: 1080-12-2

Chemical Name:: Vanillylidenacetone

Synonyms: mhsk;FEMA 3738;feruloylmethane;vanillalacetone;DEHYDROZINGERONE;Dehydrogingerone;dehydro(o)-paradol;Vanillideneacetone;VANILLYLIDENACETONE;VANILLYLIDENEACETONE

CBNumber:: CB2126546

Molecular Formula:: C11H12O3

Molecular Weight:: 192.21

MDL Number:: MFCD00012210

MOL File:: 1080-12-2.mol

MSDS File:: SDS

Last updated:2026-05-27 23:54:55

Product description	Number	Pack Size	Price
Vanillylidenacetone ≥98.5%	07551	5G-F	$102
Vanillylidenacetone ≥98.5%	07551	5G	$102
Vanillylidenacetone analytical standard	90609	100mg	$69.5
Dehydrozingerone 99.89%	orb1990519	1g	$70
4-(4-Hydroxy-3-methoxyphenyl)but-3-en-2-one 98%（trans）	AA003K14	1g	$10
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Vanillylidenacetone Properties

Melting point	125-130 °C
Boiling point	268.19°C (rough estimate)
Density	1.1503 (rough estimate)
refractive index	1.4600 (estimate)
FEMA	3738 \| VANILLYLIDENE ACETONE
FLAVIS Number	07.046 \| Vanillylidene acetone
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
pka	9.94±0.31(Predicted)
form	solid
color	Pale yellow
Odor	at 100.00 %. sweet powdery vanilla creamy balsam
Odor Type	vanilla
JECFA Number	732
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChI	1S/C11H12O3/c1-8(12)3-4-9-5-6-10(13)11(7-9)14-2/h3-7,13H,1-2H3/b4-3+
InChIKey	AFWKBSMFXWNGRE-ONEGZZNKSA-N
SMILES	COc1cc(\C=C\C(C)=O)ccc1O
LogP	1.40
CAS DataBase Reference	1080-12-2(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)	VANILLYLIDENE ACETONE
EWG's Food Scores	1
FDA UNII	8CJX5I27B7
EPA Substance Registry System	3-Buten-2-one, 4-(4-hydroxy-3-methoxyphenyl)- (1080-12-2)
UNSPSC Code	12352200
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	Eyeshields, Gloves, type N95 (US)
Risk Statements	36/37/38
Safety Statements	26-36/37/39
WGK Germany	3
RTECS	EM9960000
F	10-23
TSCA	TSCA listed
HS Code	29145090
Storage Class	11 - Combustible Solids
Toxicity	LD50 intraperitoneal in mouse: 610mg/kg

Vanillylidenacetone price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	07551	Vanillylidenacetone ≥98.5%	1080-12-2	5G-F	$102	2023-06-20	Buy
Sigma-Aldrich	07551	Vanillylidenacetone ≥98.5%	1080-12-2	5G	$102	2023-01-07	Buy
Sigma-Aldrich	90609	Vanillylidenacetone analytical standard	1080-12-2	100mg	$69.5	2022-05-15	Buy
Biorbyt Ltd	orb1990519	Dehydrozingerone 99.89%	1080-12-2	1g	$70	2026-05-06	Buy
aablocks	AA003K14	4-(4-Hydroxy-3-methoxyphenyl)but-3-en-2-one 98%（trans）	1080-12-2	1g	$10	2026-05-28	Buy

Product number	Packaging	Price	Buy
07551	5G-F	$102	Buy
07551	5G	$102	Buy
90609	100mg	$69.5	Buy
orb1990519	1g	$70	Buy
AA003K14	1g	$10	Buy

Vanillylidenacetone Chemical Properties,Uses,Production

Description

Dehydrozingerone (1080-12-2) is a structural half analog of curcumin (Cat.# 10-1243) and is isolated from ginger rhizomes. Dehydrozingerone displays antioxidant, antibacterial and antifungal properties.1 It has also been shown to possess various antitumor effects2,3 and inhibit growth factor/peroxide-stimulated vascular smooth muscle function4.

Chemical Properties

Vanillylidene acetone has a very sweet, warm and tenacious odor.

Physical properties

Yellowish, needlelike crystals. Slightly soluble in water, soluble in alcohol and oils.

Uses

Vanillylidenacetone is one of ferulic acid derivatives. Studies have shown that vanillyl acetone has a certain inhibitory effect on Amaranthus, barnyardgrass, matang, dogwood and rape, among which the best inhibitory effect is on rape and Amaranthus.

Definition

ChEBI: Dehydrozingerone is a hydroxycinnamic acid.

Taste threshold values

Taste characteristics at 200 ppm: balsamic vanilla, with sweet aromatic spicy nuances.

Synthesis

121-33-5

67-64-1

1080-12-2

General method: 20% (w/v) aqueous NaOH solution was slowly added to an ethanol solution of vanillin (6a1-d1,6e,6f) and acetone (10-25 eq., excess) at 0-5 °C. The reaction mixture was stirred at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC). When the vanillin was completely consumed, the excess acetone was evaporated under reduced pressure; subsequently, cold water was added and the resulting mixture was acidified with 3M HCl solution to pH < 7. The precipitated solid product was collected by filtration, washed with cold water and dried under vacuum. The crude product can be purified by column chromatography or recrystallized from a suitable solvent system to afford the target compound 4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one (7a1-d1,7e and 7f).

References

[1] ISMAIL RAHATH KUBRA. Structure-function activity of dehydrozingerone and its derivatives as antioxidant and antimicrobial compounds[J]. Journal of Food Science and Technology, 2011, 51 2: 245-255. DOI:10.1007/s13197-011-0488-8
[2] NORIKO MOTOHASHI . Inhibitory effects of dehydrozingerone and related compounds on 12-O-tetradecanoylphorbol-13-acetate induced Epstein–Barr virus early antigen activation[J]. Cancer letters, 1998, 134 1: Pages 37-42. DOI:10.1016/s0304-3835(98)00239-0
[3] SHINGO YOGOSAWA. Dehydrozingerone, a Structural Analogue of Curcumin, Induces Cell-Cycle Arrest at the G2/M Phase and Accumulates Intracellular ROS in HT-29 Human Colon Cancer Cells[J]. Journal of Natural Products , 2012, 75 12: 2088-2093. DOI:10.1021/np300465f
[4] YIZHEN LIU. Inhibitory effect of dehydrozingerone on vascular smooth muscle cell function.[J]. Journal of Cardiovascular Pharmacology, 2008, 52 5: 422-429. DOI:10.1097/fjc.0b013e31818aed93

Vanillylidenacetone Preparation Products And Raw materials

Raw materials

Vanillin (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE Acetone Water Ethanol

Sodium hydroxide

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Preparation Products

6-Shogaol

Vanillylidenacetone Suppliers

Global( 133)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Xianhe Biotech Co., Ltd	+86-17709210191; +8617709210191	Jerry@xhobio.com	China	906	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Xiamen Shindano Biotechnology Co.,ltd	0592-6266840 15750707980	sales@chemsdano.com	China	291	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14304	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58
Henan Alfa Chemical Co., Ltd	+8615838112936	sale03@alfachem.cn	China	9798	58

Supplier	Advantage
Shaanxi Xianhe Biotech Co., Ltd	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Xiamen Shindano Biotechnology Co.,ltd	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
Shaanxi Dideu Medichem Co. Ltd	58
Henan Alfa Chemical Co., Ltd	58

View Lastest Price from Vanillylidenacetone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	Dehydrozingerone 1080-12-2	US $0.00 / kg	1kg	0.99	1000kg	Shaanxi Xianhe Biotech Co., Ltd
2026-05-20	Dehydrozingerone 1080-12-2	US $0.00 / removed		100%	10g	TargetMol Chemicals Inc.
2026-05-20	Dehydrozingerone 1080-12-2	US $0.00 / removed		100%	10g	TargetMol Chemicals Inc.

Dehydrozingerone
1080-12-2
US $0.00 / kg
0.99
Shaanxi Xianhe Biotech Co., Ltd

Dehydrozingerone
1080-12-2
US $0.00 / removed
100%
TargetMol Chemicals Inc.

Dehydrozingerone
1080-12-2
US $0.00 / removed
100%
TargetMol Chemicals Inc.

Vanillylidenacetone Spectrum

4-(4-HYDROXY-3-METHOXYPHENYL)-3-BUTEN-2-ONE(1080-12-2)MS

1080-12-2(Vanillylidenacetone)Related Search:

Ethyl 4-hydroxy-3-methoxybenzoate Coumalic acid 2-(2-OXO-2H-CHROMEN-3-YL)ACETIC ACID 3,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER

3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE Vanillylidenacetone Isorhamnetin 3,7,3',4'-TETRAMETHYLGOSSYPETIN 3,4-DIMETHOXYBENZYLIDENEACETONE

5,7-DIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE CHRYSOERIOL Curcumin 3,4-(METHYLENEDIOXY)BENZYLIDENEACETONE SYRINGETIN

HOMOBUTEIN 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE 3'-BENZYLOXY-5,7-DIHYDROXY-3,4'-DIMETHOXYFLAVONE

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VANILLYLIDENACETONE VANILLYLIDENEACETONE VANILLYLIDINE ACETONE FEMA 3738 DEHYDROZINGERONE 4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-on dehydro(o)-paradol feruloylmethane 4-(4-HYDROXY-3-METHOXYPHENYL)-3-BUTEN-2-ONE 4-(4-HYDROXY-3-METHOXYPHENYL)-3-BUTENE-2-ONE 4-(4-HYDROXY-3-METHOXYPHENYL)BUT-3-EN-2-ONE methyl-3-methoxy-4-hydroxystyrylketone mhsk vanillalacetone Vanillideneacetone 3-Buten-2-one, 4-(4-hydroxy-3-methoxyphenyl)- 4-(3-Methoxy-4-hydroxyphenyl)-3-butene-2-one Dehydrogingerone Ferulic methyl ketone Vanillylideneacetone ,98% Dehydrozingerone Vanillylideneacetone 4-(4- hydroxy-3-Methoxyphenyl)-3- butene-2- ketone 4-(4-Hydroxy-3-methoxyphenyl)-3-buten-2-one,predominantly trans Vanillylidenacetone >=98.5% 4-(4-Hydroxy-3-methoxyphenyl)-3-buten-2-one> 4-(4-HYDROXY-3-METHOXYPHENYL)-3-BUTEN-2-ONE USP/EP/BP Vanilllylideneacetone 98%(Pre-trans) 4-(-HYDROXY-3-METHOXYPHENYL)-3-BUTEN-2-ONE 1080-12-2 1080-12-02 CH3COCHCHC6H3OCH3OH C11 to C12 Carbonyl Compounds Building Blocks Ketones Organic Building Blocks Aromatic Ketones (substituted)