5-Aminoisoindolin-1-one
- CAS No.
- 222036-66-0
- Chemical Name:
- 5-Aminoisoindolin-1-one
- Synonyms
- 5-aminoisoindolin-1-one;5-aMinoisoindoline-1-one;5-aMino-2,3-dihydro- Isoindol-1-one;5-amino-2,3-dihydro-1H-Isoindol-1-one;1H-Isoindol-1-one, 5-amino-2,3-dihydro;5-Aminoisoindolin-1-one ISO 9001：2015 REACH;1H-Isoindol-1-one,5-amino-2,3-dihydro-(9CI)
- CBNumber:
- CB21276060
- Molecular Formula:
- C8H8N2O
- Molecular Weight:
- 148.16
- MDL Number:
- MFCD10000828
- MOL File:
- 222036-66-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Aminoisoindolin-1-one | A611590 | 100mg | $165 |
| 5-Amino-2,3-dihydro-1H-isoindol-1-one 98% | 077850 | 250mg | $35 |
| 5-Aminoisoindolin-1-one | W4579 | 5g | $331 |
| 5-Amino-2,3-dihydro- isoindol-1-one 98% | 4H48-1-21 | 1g | $445 |
| 5-AMINOISOINDOLIN-1-ONE 95.00% | CHM0117386 | 100MG | $750.75 |
| More product size | |||
| Melting point | 197-199 °C(Solv: ethyl acetate (141-78-6)) |
|---|---|
| Boiling point | 520.0±50.0 °C(Predicted) |
| Density | 1.307±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | 15.12±0.20(Predicted) |
| color | Yellow |
| InChI | InChI=1S/C8H8N2O/c9-6-1-2-7-5(3-6)4-10-8(7)11/h1-3H,4,9H2,(H,10,11) |
| InChIKey | RGJCJWXNNDARPQ-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=C(N)C=C2)CN1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| HS Code | 2933998090 |
5-Aminoisoindolin-1-one price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A611590 | 5-Aminoisoindolin-1-one | 222036-66-0 | 100mg | $165 | 2021-12-16 | Buy |
| Oakwood | 077850 | 5-Amino-2,3-dihydro-1H-isoindol-1-one 98% | 222036-66-0 | 250mg | $35 | 2021-12-16 | Buy |
| AK Scientific | W4579 | 5-Aminoisoindolin-1-one | 222036-66-0 | 5g | $331 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H48-1-21 | 5-Amino-2,3-dihydro- isoindol-1-one 98% | 222036-66-0 | 1g | $445 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0117386 | 5-AMINOISOINDOLIN-1-ONE 95.00% | 222036-66-0 | 100MG | $750.75 | 2021-12-16 | Buy |
5-Aminoisoindolin-1-one Chemical Properties,Uses,Production
Uses
5-Aminoisoindolin-1-one is used in the synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on the isoindolone skeleton.
Synthesis
110568-64-4
222036-66-0
General procedure for the synthesis of 5-amino-2,3-dihydroisoindol-1-one from 6-nitro-isoindolin-1-one: A mixture of 6-nitro-isoindolin-1-one (100 mg, 0.56 mmol), and reduced iron powder (314 mg, 5.6 mmol) was added to ethanol (2.0 mL) and concentrated hydrochloric acid (0.5 mL) and heated and refluxed for 2 hours. The completion of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, it was cooled to room temperature, the acid in the reaction solution was neutralized with a methanol solution saturated with ammonia (NH3), filtered through diatomaceous earth, the filtrates were washed with methanol, the filtrates were combined and the solvent was evaporated under reduced pressure to give 5-amino-2,3-dihydroisoindol-1-one (70.0 mg, 84% yield) as a white solid.
References
[1] Patent: CN103804358, 2016, B. Location in patent: Paragraph 0126
[2] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 57
[3] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 287
[4] Patent: WO2006/17443, 2006, A2. Location in patent: Page/Page column 154-155
[5] Patent: US2010/15141, 2010, A1. Location in patent: Page/Page column 26
5-Aminoisoindolin-1-one Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29794 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 9545 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9080 | 58 |
View Lastest Price from 5-Aminoisoindolin-1-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 5-Aminoisoindolin-1-one
222036-66-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2021-07-13 | 1H-Isoindol-1-one, 5-amino-2,3-dihydro
222036-66-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | 1H-Isoindol-1-one, 5-amino-2,3-dihydro
222036-66-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Aminoisoindolin-1-one
222036-66-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 1H-Isoindol-1-one, 5-amino-2,3-dihydro
222036-66-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1H-Isoindol-1-one, 5-amino-2,3-dihydro
222036-66-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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