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ChemicalBook >> CAS DataBase List >>4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester

4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester

4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester Structure
4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester structure
CAS No.
374679-63-7
Chemical Name:
4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester
Synonyms
AKOS B016273;ART-CHEM-BB B016273;SALOR-INT L100021-1EA;Methyl 3,4-dichloro-α,γ-dioxobenzenebutanoate;Methyl 3,4-dichloro-α,γ-dioxobenzenebutanoate;Methyl 3,4-dichloro-a,g-dioxo-benzenebutanoate;METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE;4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester;Benzenebutanoic acid, 3,4-dichloro-α,γ-dioxo-, methyl ester
CBNumber:
CB2133270
Molecular Formula:
C11H8Cl2O4
Molecular Weight:
275.08
MDL Number:
MFCD03001261
MOL File:
Mol file
MSDS File:
SDS
Last updated:2026-09-12 18:50:13
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4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester Properties

Melting point 127-129°C
Boiling point 423.0±40.0 °C(Predicted)
Density 1.410±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 5.72±0.48(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HazardClass  IRRITANT

4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L100021 METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE AldrichCPR 374679-63-7 1 unit $32.7 2026-04-30 Buy
Sigma-Aldrich L100021 METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE AldrichCPR 374679-63-7 10MG $29.8 2024-03-01 Buy
Biosynth ZPA67963 Methyl 4-(3,4-dichlorophenyl)-2,4-dioxobutanoate 374679-63-7 2.5g $354 2026-06-05 Buy
Matrix Scientific 044520 Methyl 4-(3,4-dichlorophenyl)-2,4-dioxobutanoate 374679-63-7 500.00mg $33 2026-05-18 Buy
Matrix Scientific 044520 Methyl 4-(3,4-dichlorophenyl)-2,4-dioxobutanoate 374679-63-7 1.00g $50 2026-05-18 Buy
Product number Packaging Price Buy
L100021 1 unit $32.7 Buy
L100021 10MG $29.8 Buy
ZPA67963 2.5g $354 Buy
044520 500.00mg $33 Buy
044520 1.00g $50 Buy

4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester Chemical Properties,Uses,Production

Synthesis

Dimethyl oxalate

553-90-2

3',4'-DICHLOROACETOPHENONE

2642-63-9

4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER

374679-63-7

General procedure for the synthesis of methyl 4-(3,4-dichlorophenyl)-2,4-dicarbonylbutyrate from dimethyl oxalate and 3,4-dichloroacetophenone: dimethyl oxalate (5.9 g, 50 mmol) was slowly added to a suspension of freshly prepared sodium methanolate (3.24 g, 60 mmol) in anhydrous toluene at 8-10 °C. Subsequently, 3,4-dichloroacetophenone (6.7 g, 50 mmol) was added dropwise over 30 min. The reaction mixture was stirred overnight at 8-10 °C and under nitrogen protection. After completion of the reaction, the yellow precipitate was obtained by filtration and washed with toluene (2 x 20 ml), then the precipitate was dissolved in water (20 mL) and acidified by adding 25 ml of 6N HCl. The organic layer was extracted with diisopropyl ether, followed by washing the organic layer with brine, drying with anhydrous sodium sulfate, and finally evaporating the solvent to give pure methyl 4-(3,4-dichlorophenyl)-2,4-dicarbonylbutyrate (8a-e) as a yellow solid in good yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 8, p. 2077 - 2083
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 273 - 280

4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester Preparation Products And Raw materials

Raw materials

Dimethyl oxalate 3',4'-Dichloroacetophenone

Preparation Products

4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester Suppliers

Global( 43)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Amatek Scientific Co. Ltd. 0512-56316828 4008675858 sales@amateksci.com China 9849 55
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
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Dayang Chem (Hangzhou) Co.,Ltd. +86-0571-88938639 17705817739 info@dycnchem.com China 52693 58
Career Henan Chemica Co +86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Zhejiang Lianshuo Biotechnology Co., Ltd. 18616526224 lianshuo@vip.126.com China 9605 58
Changzhou Yinghao Technology Development Co., Ltd 15151934985 sales@yingsapharm.com China 5457 58
Supplier Advantage
Wuhan Chemwish Technology Co., Ltd 56
Shanghai Hanhong Scientific Co.,Ltd. 64
Amatek Scientific Co. Ltd. 55
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Shanghai HuanChuan Industry Co.,Ltd. 50
Amadis Chemical Company Limited 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
Career Henan Chemica Co 58
Zhejiang Lianshuo Biotechnology Co., Ltd. 58
Changzhou Yinghao Technology Development Co., Ltd 58

4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester Spectrum

4-(3,4-DICHLORO-PHENYL)-2,4-DIOXO-BUTYRIC ACID METHYL ESTER(374679-63-7)1HNMR

374679-63-7(4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester)Related Search:

Ethyl 4-(4-chlorophenyl)-2,4-dioxobutanoate Methyl 3-chloro-a,g-dioxo-benzenebutanoate Benzenebutanoic acid, 2,5-dichloro-α,γ-dioxo-, methyl ester Methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate Benzenebutanoic acid, 3,4-dichloro-.alpha.,.gaMMa.-dioxo-, ethyl
Methyl 4-(2-chlorophenyl)-2,4-dioxobutanoate

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AKOS B016273 METHYL 4-(3,4-DICHLOROPHENYL)-2,4-DIOXOBUTANOATE ART-CHEM-BB B016273 SALOR-INT L100021-1EA Methyl 3,4-dichloro-a,g-dioxo-benzenebutanoate Benzenebutanoic acid, 3,4-dichloro-α,γ-dioxo-, methyl ester Methyl 3,4-dichloro-α,γ-dioxobenzenebutanoate Methyl 3,4-dichloro-α,γ-dioxobenzenebutanoate 4-(3,4-Dichloro-phenyl)-2,4-dioxo-butyric acid methyl ester 374679-63-7 C11H8Cl2O4