6,7-dichloroquinoline-5,8-dione
- CAS No.
- 6541-19-1
- Chemical Name:
- 6,7-dichloroquinoline-5,8-dione
- Synonyms
- 6，7-dichloro9uinoline-5,8-dione;6,7-dichloroquinoline-5,8-dione;5,8-Quinolinedione, 6,7-dichloro-
- CBNumber:
- CB21335666
- Molecular Formula:
- C9H3Cl2NO2
- Molecular Weight:
- 228.03
- MDL Number:
- MFCD00512152
- MOL File:
- 6541-19-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 6,7-Dichloroquinoline-5,8-dione | TMT00350 | 1 g | $586 |
| 6,7-Dichloroquinoline-5,8-dione | D439940 | 25g | $50 |
| 6,7-Dichloroquinoline-5,8-dione 98% | A657071 | 100mg | $62 |
| 6,7-Dichloroquinoline-5,8-dione 98% | A657071 | 250mg | $118 |
| 6,7-Dichloroquinoline-5,8-dione 98% | A657071 | 1g | $297 |
| Melting point | 220-222 °C |
|---|---|
| Boiling point | 331.1±42.0 °C(Predicted) |
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly) |
| pka | -3.44±0.20(Predicted) |
| form | Solid |
| color | Pale Yellow to Orange |
| InChI | 1S/C9H3Cl2NO2/c10-5-6(11)9(14)7-4(8(5)13)2-1-3-12-7/h1-3H |
| InChIKey | TUWOPVCIIBKUQS-UHFFFAOYSA-N |
| SMILES | O=C(C(Cl)=C(Cl)C1=O)C2=C1N=CC=C2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
6,7-dichloroquinoline-5,8-dione price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | TMT00350 | 6,7-Dichloroquinoline-5,8-dione | 6541-19-1 | 1 g | $586 | 2026-04-30 | Buy |
| TRC | D439940 | 6,7-Dichloroquinoline-5,8-dione | 6541-19-1 | 25g | $50 | 2021-12-16 | Buy |
| Ambeed | A657071 | 6,7-Dichloroquinoline-5,8-dione 98% | 6541-19-1 | 100mg | $62 | 2021-12-16 | Buy |
| Ambeed | A657071 | 6,7-Dichloroquinoline-5,8-dione 98% | 6541-19-1 | 250mg | $118 | 2021-12-16 | Buy |
| Ambeed | A657071 | 6,7-Dichloroquinoline-5,8-dione 98% | 6541-19-1 | 1g | $297 | 2021-12-16 | Buy |
6,7-dichloroquinoline-5,8-dione Chemical Properties,Uses,Production
Uses
6,7-Dichloroquinoline-5,8-dione is a reagent used in the synthesis of pharmaceuticals, such as a platinum(II) complex with antitumor activity.
Synthesis
148-24-3
6541-19-1
General procedure for the synthesis of 6,7-dichloroquinoline-5,8-dione from 8-hydroxyquinoline: sodium chlorate (0.50 mol) was slowly added to a solution of 8-hydroxyquinoline (0.10 mol) dissolved in concentrated hydrochloric acid (600 mL) over a period of 1 hour. The reaction mixture was stirred continuously at 40°C for 2 hours. Subsequently, the reaction solution was diluted with water to a total volume of 2 L. The resulting white precipitate was removed by filtration and discarded. The filtrate was extracted several times with dichloromethane (6 x 250 mL), all organic phases were combined, washed with water and concentrated under reduced pressure to give a yellow solid product. The solid product was recrystallized in methanol to give the final 6,7-dichloroquinoline-5,8-dione (compound 7) as bright yellow crystals. The characterization data of compound 7 was in agreement with that reported in literature [32].
References
[1] RSC Advances, 2015, vol. 5, # 78, p. 63330 - 63337
[2] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 8, p. 4617 - 4625
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 8, p. 1329 - 1340
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 9, p. 3238 - 3251
[5] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 423 - 436
6,7-dichloroquinoline-5,8-dione Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
6,7-dichloroquinoline-5,8-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5973 | 58 |
| Hunan Jibang Biological Technology Co., LTD | +8613776644403 | sales02@kingboomtech.com | China | 1804 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33324 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Changsha Luxing Bio-Chem Technology Co., Ltd. | 0731-88827538 15873153880 | luxingbc@126.com | China | 1991 | 65 |
| Chongqing Chemieliva Pharmaceutical Co., Ltd. | 18696571988 | amy.lei@chemieliva.com | China | 1558 | 60 |
| Wuhan EEChem Technologies Co., Ltd | 0711-3617768 13308685235 | lihongcai4360@sina.com | China | 1541 | 55 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16027 | 58 |
| Cool Pharm, Ltd | 021-58581007 18019463053 | sales@coolpharm.com | China | 10000 | 58 |
| Beijing Minruida Technology Co., Ltd. | 010-82387566 18001021521; | sales@mreda.com.cn | China | 10083 | 58 |
