Iluzanebart
- CAS No.
- 2733621-19-5
- Chemical Name:
- Iluzanebart
- Synonyms
- Iluzanebart;Research Grade Iluzanebart
- CBNumber:
- CB213380874
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
- MSDS File:
- SDS
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | 23Q5AU2MD5 |
Iluzanebart price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0900541 | Iluzanebart 98.63% | 2733621-19-5 | 1mg | $325 | 2026-06-04 | Buy |
| ChemScene | CS-0900541 | Iluzanebart 98.63% | 2733621-19-5 | 5mg | $812 | 2026-06-04 | Buy |
| ChemScene | CS-0900541 | Iluzanebart 98.63% | 2733621-19-5 | 10mg | $1300 | 2026-06-04 | Buy |
| Biorbyt Ltd | orb1942689 | Iluzanebart Antibody 95.00% | 2733621-19-5 | 1mg | $290 | 2026-05-06 | Buy |
| Biorbyt Ltd | orb1942689 | Iluzanebart Antibody 95.00% | 2733621-19-5 | 5mg | $670 | 2026-05-06 | Buy |
Iluzanebart Chemical Properties, Uses, Production
Uses
Iluzanebart is a human monoclonal IgG1 antibody and is the agonist antibody for human TREM2 (hTREM2). Iluzanebart improves the survival and function of microglia by activating the TREM2 signaling pathway to compensate for the loss of CSF1R function. Iluzanebart can be used for research of adult-onset leukoencephalopathy associated with CSF1R (colony stimulating factor 1 receptor) (CSF1R-ALSP)[1].
in vivo
Iluzanebart (1-200 mg/kg, ip, single dose) increases microglia proliferation and CSF1R levels in human TREM2 expressing transgenic mice models[1].
| Animal Model: | Human TREM2 expressing transgenic mice models[1] |
| Dosage: | 1-200 mg/kg |
| Administration: | ip, single dose |
| Result: | Increased the number of Ki67 positive microglia, the mean fluorescence intensity (MFI) of microglia with high CSF1R levels and the protein levels of specific chemokines such as IP10 and MIP1α. |
References
[1] Larson KC, et al., Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism. J Neuroinflammation. 2025 Jan 31;22(1):26. DOI:10.1186/s12974-025-03346-1
Iluzanebart Preparation Products And Raw materials
Raw materials
Preparation Products
Iluzanebart Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988941452 | YN_research@163.com | China | 2984 | 58 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1577 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 4593 | 58 |
| Wanxin Biotechnology (Jiaxing) Co., LTD | 0573-83568680 18057391398 | 3956524501@qq.com | China | 1441 | 58 |
| Atagenix Laboratories | 027-87008169 17762441161 | info@atagenix.com | China | 9997 | 58 |
| Wuhan Maixi Biotechnology Co., Ltd | 18007167883 18007167883 | Service@mabnus.com | China | 921 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
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