LY 223982
- CAS No.
- 117423-74-2
- Chemical Name:
- LY 223982
- Synonyms
- CGS23131;LY 223982;SKF107324);LY223982,LY-223982;LY223982 Exclusive;SYZSSLLFRVDRHL-QPJJXVBHSA-N;LY223982 (Synonyms: CGS23131;5-(3-Carboxybenzoyl)-2-[(E)-6-(4-methoxyphenyl)-5-hexenyloxy]benzenepropanoic acid;Benzenepropanoic acid, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-
- CBNumber:
- CB21341434
- Molecular Formula:
- C30H30O7
- Molecular Weight:
- 502.55
- MDL Number:
- MFCD00876442
- MOL File:
- 117423-74-2.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| LY223982 ≥98% | 10010024 | 1mg | $28 |
| LY223982 ≥98% | 10010024 | 5mg | $117 |
| LY223982 ≥98% | 10010024 | 10mg | $207 |
| LY223982 ≥98% | 10010024 | 25mg | $448 |
| LY223982 | L503108 | 1mg | $40 |
| Melting point | 151-152 °C |
|---|---|
| Boiling point | 753.8±60.0 °C(Predicted) |
| Density | 1.235±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly) |
| form | A crystalline solid |
| pka | 3.81±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | XG52JC545T |
LY 223982 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10010024 | LY223982 ≥98% | 117423-74-2 | 1mg | $28 | 2024-03-01 | Buy |
| Cayman Chemical | 10010024 | LY223982 ≥98% | 117423-74-2 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 10010024 | LY223982 ≥98% | 117423-74-2 | 10mg | $207 | 2024-03-01 | Buy |
| Cayman Chemical | 10010024 | LY223982 ≥98% | 117423-74-2 | 25mg | $448 | 2024-03-01 | Buy |
| TRC | L503108 | LY223982 | 117423-74-2 | 1mg | $40 | 2021-12-16 | Buy |
LY 223982 Chemical Properties,Uses,Production
Description
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-
Uses
LY223982 is a potent P2Y7 (BLT1) receptor antagonist.
in vivo
LY223982 inhibits transient leukopenia induced in rabbits with LTB4 (ED50, 3 mg/kg) but not with FMLP, and shows no agonist activity in any of the test systems[1].
IC 50
LTB4: 13.2 nM (IC50)
References
[1] D. MARK GAPINSKI. Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain[J]. Journal of Medicinal Chemistry, 1990, 33 10: 2807-2813. DOI: 10.1021/jm00172a020
[2] W T JACKSON. Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982.[J]. Journal of Pharmacology and Experimental Therapeutics, 1992, 263 3: 1009-1014.
[3] T. YOKOMIZO. Hydroxyeicosanoids Bind to and Activate the Low Affinity Leukotriene B4 Receptor, BLT2*[J]. The Journal of Biological Chemistry, 2001, 3 1: 12454-12459. DOI: 10.1074/jbc.m011361200
LY 223982 Preparation Products And Raw materials
Raw materials
Preparation Products
LY 223982 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19957 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3505 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3291 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24960 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
