LAVENDUSTIN A
- CAS No.
- 125697-92-9
- Chemical Name:
- LAVENDUSTIN A
- Synonyms
- RG14355;NSC 678027;LAVENDUSTIN A;Lavendustin A,98%;RG-14355;NSC 678027;LAVENDUSTIN A USP/EP/BP;Lavendustin A, tyrosine kinase inhibitor;Lavendustin A - CAS 125697-92-9 - Calbiochem;5-AMINO-[(N-2,5-DIHYDROXYBENZYL)-N'-2-HYDROXYBENZYL]SALICYLIC ACID;5-[(2,5-Dihydroxybenzyl)(2-hydroxybenzyl)amino]-2-hydroxybenzoic acid
- CBNumber:
- CB2135704
- Molecular Formula:
- C21H19NO6
- Molecular Weight:
- 381.38
- MDL Number:
- MFCD00153822
- MOL File:
- 125697-92-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Lavendustin A | 428150 | 1mg | $238 |
| Lavendustin A ≥95% | 10010268 | 1mg | $90 |
| Lavendustin A ≥95% | 10010268 | 5mg | $197 |
| Lavendustin A ≥95% | 10010268 | 10mg | $349 |
| Lavendustin A ≥95% | 10010268 | 1mg | $81 |
| More product size | |||
| Melting point | 205-215 °C |
|---|---|
| Boiling point | 741.7±60.0 °C(Predicted) |
| Density | 1.495±0.06 g/cm3(Predicted) |
| RTECS | DG8578950 |
| storage temp. | −20°C |
| solubility | DMSO: soluble |
| pka | 2.31±0.10(Predicted) |
| form | crystalline |
| color | Yellow to brown |
| Sensitive | Air Sensitive |
| Stability | Moisture Sensitive: Hygroscopic |
| InChI | 1S/C21H19NO6/c23-16-6-8-19(25)14(9-16)12-22(11-13-3-1-2-4-18(13)24)15-5-7-20(26)17(10-15)21(27)28/h1-10,23-26H,11-12H2,(H,27,28) |
| InChIKey | ULTTYPMRMMDONC-UHFFFAOYSA-N |
| SMILES | N(Cc3c(ccc(c3)O)O)(Cc2c(cccc2)O)c1cc(c(cc1)O)C(=O)O |
| CAS DataBase Reference | 125697-92-9(CAS DataBase Reference) |
| FDA UNII | 3Y0G32G2RV |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 37/39-26 |
| WGK Germany | 3 |
| HS Code | 29225000 |
| Storage Class | 11 - Combustible Solids |
LAVENDUSTIN A price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 428150 | Lavendustin A | 125697-92-9 | 1mg | $238 | 2026-04-30 | Buy |
| Cayman Chemical | 10010268 | Lavendustin A ≥95% | 125697-92-9 | 1mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 10010268 | Lavendustin A ≥95% | 125697-92-9 | 5mg | $197 | 2026-04-30 | Buy |
| Cayman Chemical | 10010268 | Lavendustin A ≥95% | 125697-92-9 | 10mg | $349 | 2026-04-30 | Buy |
| Cayman Chemical | 10010268 | Lavendustin A ≥95% | 125697-92-9 | 1mg | $81 | 2024-03-01 | Buy |
LAVENDUSTIN A Chemical Properties,Uses,Production
Description
Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 μM). It has been used to differentiate rat mesenchymal stem cells, to inhibit NMDA-stimulated cGMP production, and to inhibit VEGF-induced angiogenesis.
Chemical Properties
Off-White Solid
Uses
A potent tyrosine kinase inhibitor. Inhibition is competitive with ATP and is noncompetitive with the peptide.
Definition
ChEBI: 5-[(2,5-dihydroxyphenyl)methyl-[(2-hydroxyphenyl)methyl]amino]-2-hydroxybenzoic acid is an aromatic amine.
Biological Activity
Potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC 50 = 11 nM). Inhibits p60 c-src with an IC 50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC 50 > 100 μ M).
target
EGFR | PKC | PI3K | Calcium Channel
References
[1] TOSHIHIKO ONODA. Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, from Streptomyces griseolavendus[J]. Journal of Natural Products , 1989, 52 6: 1252-1257. DOI: 10.1021/np50066a009
[2] C Y HSU. Kinetic analysis of the inhibition of the epidermal growth factor receptor tyrosine kinase by Lavendustin-A and its analogue.[J]. The Journal of Biological Chemistry, 1991, 266 31: 21105-21112.
[3] KI-CHUL HWANG. Chemicals that modulate stem cell differentiation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 7467-7471. DOI: 10.1073/pnas.0802825105
[4] THOMAS J. O’’DELL Seth G N G Eric R Kandel. Long-term potentiation in the hippocampus is blocked by tyrosine kinase inhibitors[J]. Nature, 1991, 353 6344: 558-560. DOI: 10.1038/353558a0
[5] T P FAN R B R Jaggar. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy.[J]. Trends in pharmacological sciences, 1995, 16 2: 57-66. DOI: 10.1016/s0165-6147(00)88979-8
LAVENDUSTIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5742 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20405 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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