TIMP-1, HUMAN
- CAS No.
- Chemical Name:
- TIMP-1, HUMAN
- Synonyms
- TIMP-1;TIMP;HUMAN TIMP-1;TIMP-1, HUMAN;TIMP-1 protein;TIMP recombinant;TIMP-1, HUMAN PROTEIN;Mouse Anti-TIMP-1 antibody;TIMP-1, RECOMBINANT, HUMAN;Human TIMP1 Protein, His Tag
- CBNumber:
- CB2136529
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00285922
- MOL File:
- Mol file
TIMP-1, HUMAN price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP6445 | TIMP1 human recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE) | 10μg | $400 | 2026-04-30 | Buy | |
| Sigma-Aldrich | SRP3173 | TIMP-1 human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture | 10μg | $395 | 2026-04-30 | Buy | |
| Sigma-Aldrich | 612080 | TIMP-1, Human Neutrophil Granulocyte Native TIMP-1 from human granulocyte. | 5μG | $444 | 2026-04-30 | Buy | |
| Sigma-Aldrich | T8947 | Tissue Inhibitor of Metalloproteinase-1 human recombinant, expressed in CHO cells, ~500?μg/mL protein, buffered aqueous solution | 5μg | $817 | 2023-06-20 | Buy | |
| Sigma-Aldrich | SRP6040 | TIMP-1 human recombinant, expressed in Sf9 cells, ≥92% (SDS-PAGE) | 5μg | $426 | 2023-01-07 | Buy |
TIMP-1, HUMAN Chemical Properties, Uses, Production
Species
Human
Uses
TIMP-1 human has been used for inhibition assays in enzymatic activity assays of Mmp1-CD and Mmp2-CD. It has also been used in interaction immunoassay.
Biological Activity
TIMP1 functions as a poor inhibitor of MT1 (membrane type 1)-MMP, MT3-MMP, MT5-MMP and MMP-19. It inhibits ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) protein. In HUVECs, the down-regulation of TIMP1 and up-regulation of MMP-3 results in aberrant endothelium-dependent vasodilation, EC (endothelial cell) death, and endothelial interruption in a FOXO3 (forkhead box O3)-mediated manner. In patients with CAD (coronary artery disease) and acute coronary syndrome (ACS), the urine levels of this protein are elevated. This protein interacts with Bcl-2 (B cell lymphoma) protein, and induces apoptosis in lung adenocarcinoma cells. The plasma levels of this protein are increased in patients with obesity and obesity-related disorders, such as steatosis, where it participates in pathogenesis of diet-induced hepatic steatosis and glucose intolerance.
target
FMO5
Description
TIMP1 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 184 amino acids fragment (24-207) having a total molecular mass of 25.21kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TIMP1 is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
TIMP1 is a member of the TIMP family. TIMP1 is an inducible glycoprotein produced by various cell types. The TIMP1 glycoprotein is a natural inhibitor of the matrix metalloproteinases, which a group of peptidases involved in degradation of the extracellular matrix. TIMP1 binds in a reversible mode to MMPs, with regions in the N-terminal domain binding to the MMP substrate-binding site. On top of its inhibitory function against most of the known MMPs, TIMP1 is able to promote cell proliferation in a broad range of cell types, and may also have an anti-apoptotic role. Furthermore, TIMP1 has erthyroid-potentiating activity via translocation to the nucleus and also inhibits apoptosis in B-cells.
The TIMP1 gene is situated within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 activity is dependent on the existence of disulfide bonds.
TIMP1 transcription is extremely inducible in reaction to many cytokines and hormones.
Increased TIMP1 levels are connected with squamous cell laryngeal carcinoma. TIMP1 overexpression is linked to gastric cancer.
Source_Species
Human
Conjugations
Unconjugated
Expression_System
293T Cells
Tag
Myc-DDK -Flag
TIMP-1, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
TIMP-1, HUMAN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 9926 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10305 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Biolab Reagents | 027-65279366 18108604356 | products@biolabreagent.com | China | 9864 | 58 |
| ACROBiosystems | 13121935750 | jiaxin.zhao@acrobiosystems.com | China | 1592 | 58 |
| Shanghai Yubo Biotechnology Co., Ltd | 021-60514606 18321282235 | sale1@shybsw.net | China | 8165 | 58 |
| shlmai | 021-67680335 13052188602 | sale1@shlmai.net | China | 10000 | 58 |
| TargetMol | 400-821-0310 15002144251 | xuexiang.shao@tsbiochem.com | China | 29128 | 58 |
