norathyriol
- CAS No.
- 3542-72-1
- Chemical Name:
- norathyriol
- Synonyms
- rathyriol;norathyriol;Mangiferitin;Norathyriol, 10 mM in DMSO;1,3,6,7-Tetrahydroxyxanthone;1,3,6,7-Tetrahydroxy-9H-xanthen-9-one;9H-Xanthen-9-one, 1,3,6,7-tetrahydroxy-
- CBNumber:
- CB21387988
- Molecular Formula:
- C13H8O6
- Molecular Weight:
- 260.2
- MDL Number:
- MFCD13689186
- MOL File:
- 3542-72-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
norathyriol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Arctom | AS296873 | Norathyriol ≥98% | 3542-72-1 | 5mg | $327 | 2021-12-16 | Buy |
| Aaron Chemicals | AR00C7EJ | norathyriol 98% | 3542-72-1 | 5mg | $393 | 2021-12-16 | Buy |
| Arctom | CFN98468 | Norathyriol | 3542-72-1 | 5mg | $463 | 2021-12-16 | Buy |
| Crysdot | CD32001572 | Norathyriol 95+% | 3542-72-1 | 5mg | $730 | 2021-12-16 | Buy |
| CSNpharm | CSN13488 | Norathyriol | 3542-72-1 | 5mg | $833 | 2021-12-16 | Buy |
norathyriol Chemical Properties,Uses,Production
Uses
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12?μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.
Definition
ChEBI: A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity again t protein kinase C.
in vivo
Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7?mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4].
| Animal Model: | Adult Kunming mice weighing 18-22?g[4] |
| Dosage: | 0.92, 1.85 and 3.7?mg/kg |
| Administration: | Administered intragastrically; twice daily for five times |
| Result: | The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%. |
IC 50
PPARα: 92.8 μM (IC50); PPARβ: 102.4 μM (IC50); PPARγ: 153.5 μM (IC50)
References
[1] Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015. DOI:10.1155/2017/1206015
[2] Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42. DOI:10.1021/jf800046n
[3] Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70. DOI:10.1158/0008-5472.CAN-11-2596
[4] Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6. DOI:10.3109/13880209.2015.1120322
norathyriol Preparation Products And Raw materials
norathyriol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3944 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3292 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Aktin Chemicals, Inc. | 028-85159085 | info@aktinchem.com | CHINA | 1025 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| Weifang Wehibest Supply Chain Co.,Ltd | +8613583620690 | hotspotbiotech@163.com | China | 926 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 |
View Lastest Price from norathyriol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-29 | Norathyriol
3542-72-1
|
US $152.00-556.00 / mg | 98.93% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-01-03 | norathyriol
3542-72-1
|
US $0.00-0.00 / KG | 5mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-07-20 | Norathyriol
3542-72-1
|
US $1.00 / Kg | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- Norathyriol
3542-72-1
- US $152.00-556.00 / mg
- 98.93%
- TargetMol Chemicals Inc.
-
- norathyriol
3542-72-1
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- Norathyriol
3542-72-1
- US $1.00 / Kg
- 98%
- Shaanxi Dideu Medichem Co. Ltd