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(S)-(+)-3-Hydroxytetrahydrofuran

(S)-(+)-3-Hydroxytetrahydrofuran Structure
(S)-(+)-3-Hydroxytetrahydrofuran structure
CAS No.
86087-23-2
Chemical Name:
(S)-(+)-3-Hydroxytetrahydrofuran
Synonyms
(S)-TETRAHYDROFURAN-3-OL;(S)-3-HYDROXYTETRAHYDROFURAN;(3S)-Tetrahydrofuran-3-ol;(3S)-oxolan-3-ol;(S)-(-)-3-HYDROXY TETRAHYDRO FURAN;S-HTHF;Oxolane-3β-ol;(S)-Hydroxy THF;Afatinib intermediate;S-3- Hydroxytetrafuran
CBNumber:
CB2142463
Molecular Formula:
C4H8O2
Molecular Weight:
88.11
MDL Number:
MFCD00064327
MOL File:
86087-23-2.mol
MSDS File:
SDS
Last updated:2026-04-01 08:42:05
Product description Number Pack Size Price
(S)-(+)-3-Hydroxytetrahydrofuran 99% 296686 5g $70.1
(S)-(+)-3-Hydroxytetrahydrofuran 99% 296686 25g $114
(S)-3-Hydroxytetrahydrofuran >98.0%(GC) T1716 1g $17
(S)-3-Hydroxytetrahydrofuran >98.0%(GC) T1716 5g $39
(S)-(+)-3-Hydroxytetrahydrofuran H957755 50g $620
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(S)-(+)-3-Hydroxytetrahydrofuran Properties

alpha 18.5 º (c=2 MeOH)
Boiling point 80 °C/15 mmHg (lit.)
Density 1.103 g/mL at 25 °C (lit.)
vapor pressure 47Pa at 25℃
refractive index n20/D 1.45(lit.)
Flash point 175 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Chloroform, Methanol (Slightly)
form Liquid
pka 14.49±0.20(Predicted)
color Clear colorless to pale yellow
Specific Gravity 1.11
optical activity [α]20/D +17.5°, c = 2.4 in methanol
Water Solubility soluble
BRN 4652609
Stability Stable. Combustible. Incompatible with strong oxidizing agents.
InChI 1S/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2/t4-/m0/s1
InChIKey XDPCNPCKDGQBAN-BYPYZUCNSA-N
SMILES O[C@H]1CCOC1
LogP -0.784 at 22℃ and pH6.8
Surface tension 72mN/m at 1g/L and 25℃
CAS DataBase Reference 86087-23-2(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
RIDADR  NA 1993 / PGIII
WGK Germany  3
HS Code  29321900
Storage Class 10 - Combustible liquids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

(S)-(+)-3-Hydroxytetrahydrofuran price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 296686 (S)-(+)-3-Hydroxytetrahydrofuran 99% 86087-23-2 5g $70.1 2026-03-19 Buy
Sigma-Aldrich 296686 (S)-(+)-3-Hydroxytetrahydrofuran 99% 86087-23-2 25g $114 2026-03-19 Buy
TCI Chemical T1716 (S)-3-Hydroxytetrahydrofuran >98.0%(GC) 86087-23-2 1g $17 2026-03-19 Buy
TCI Chemical T1716 (S)-3-Hydroxytetrahydrofuran >98.0%(GC) 86087-23-2 5g $39 2026-03-19 Buy
TRC H957755 (S)-(+)-3-Hydroxytetrahydrofuran 86087-23-2 50g $620 2021-12-16 Buy
Product number Packaging Price Buy
296686 5g $70.1 Buy
296686 25g $114 Buy
T1716 1g $17 Buy
T1716 5g $39 Buy
H957755 50g $620 Buy

(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties,Uses,Production

Description

(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.

Chemical Properties

Colourless Liquid

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.

Uses

(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.

Application

(S)-(+)-3-Hydroxytetrahydrofuran is used as a synthetic intermediate for Empagliflozin, Afatinib and GS-9669.

Synthesis

(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows：To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.S)-(+)-3-Hydroxytetrahydrofuran synthesis

References

[1] Journal of Organic Chemistry, 1983, vol. 48, # 16, p. 2767 - 2769
[2] Patent: WO2007/81065, 2007, A1. Location in patent: Page/Page column 5
[3] Patent: WO2007/81065, 2007, A1. Location in patent: Page/Page column 6; 7
[4] Patent: US5576343, 1996, A

(S)-(+)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials

Raw materials

L-Malic acid p-Toluenesulfonic acid Ethanol Toluene Tetrahydrofuran
Ethyl acetate Lithium Aluminum Hydride Methanol (S)-1,2,4-Butanetriol (S)-4-Chloro-1,3-butanediol

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Preparation Products

(R)-(-)-3-Hydroxytetrahydrofuran (S)-3-P-MESYLOXYTETRAHYDROFURAN (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(S)-(+)-3-Hydroxytetrahydrofuran Suppliers

Global( 754)Suppliers
Supplier Tel Email Country ProdList Advantage
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
027-88013699 17354350817 Ryan@jiutian-bio.com China 5945 58
Porton Pharma Solutions Ltd.
China 56 58
Shanghai Yongzeng Technology Co.,Ltd
+8613818947575 sales@yongzchem.com China 142 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5235 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-18712993135 sales01@tairunfaz.com China 8051 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 deasea125996@gmail.com China 2472 58
Wuhan JiyunZen Tech Co., Ltd. 		+86-18062099985 Amyjiyunzen@yeah.net China 672 58
Supplier Advantage
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
58
Porton Pharma Solutions Ltd.
58
Shanghai Yongzeng Technology Co.,Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Fengjia New Material Co., Ltd 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Bao Enluo International TradeCo.，LTD 		58
Wuhan JiyunZen Tech Co., Ltd. 		58

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View Lastest Price from (S)-(+)-3-Hydroxytetrahydrofuran manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(+)-3-Hydroxytetrahydrofuran pictures 2026-04-22 (S)-(+)-3-Hydroxytetrahydrofuran
86087-23-2
 0.99 RongNa Biotechnology Co.,Ltd
(S)-(+)-3-Hydroxytetrahydrofuran pictures 2026-04-22 (S)-(+)-3-Hydroxytetrahydrofuran
86087-23-2
 US $0.00 / KG 1KG 99% GC 100kg WUHAN FORTUNA CHEMICAL CO., LTD
(S)-(+)-3-Hydroxytetrahydrofuran pictures 2026-04-22 (S)-(+)-3-Hydroxytetrahydrofuran
86087-23-2
 US $100.00 / kg 1kg 99%min 1 tons Shanghai Yongzeng Technology Co.,Ltd

(S)-(+)-3-Hydroxytetrahydrofuran Spectrum

(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)MS(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)1HNMR(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)13CNMR(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)IR1(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)Raman

86087-23-2((S)-(+)-3-Hydroxytetrahydrofuran)Related Search:

Tetrahydrofuran 2-Methyltetrahydrofuran 3-(S)-HYDROXY TETRAHYDROFURAN 3-HYDROXYTETRAHYDROFURAN 99%,3-HYDROXYTETRAHYDROFURAN (RS)-3-Hydroxytetrahydrofuran
POLY(TETRAHYDROFURAN) STANDARD 15000 (R)-(+)-3-HYDROXYTETRAHYDROFURAN-2-ONE α-D-erythro-Pentofuranose-2-deoxy-2,2-difluoro-3,5-dibenzoate (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE,4(S)-Hydroxytetrahydrofuran-2-ONE 3-HYDROXYTETRAHYDROFURAN-2-ONE,2-Hydroxytetrahydrofuran-2-one
(R)-(-)-3-HYDROXYTETRAHYDROFURAN,(R)-3-HYDROXYTETRAHYDROFURAN ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate (S)-(+)-3-HYDROXYTETRAHYDROFURAN-D4 (3R)-3β,4α-Bis(3-methoxy-4-hydroxybenzyl)-3-hydroxytetrahydrofuran-2-one (2R, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL
(2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL (2S, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL 4-HYDROXYTETRAHYDROFURAN-2-METHANOL

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(S)-(+)-TETRAHYDRO-3-FURANOL (S)-(+)-3-HYDROXY TETAHYDRO FURAN (S)-(-)-3-HYDROXY TETRAHYDRO FURAN (3S)-oxolan-3-ol (2S)-1,4-Epoxy-2-hydroxybutane, (3S)-Tetrahydrofuran-3-ol, (3S)-Oxolan-3-ol Afatinib intermediate B (S)-(+)-3-Hydroxytetrahydrofuran, ee: 95% Afatinib intermediate (S)-(+)-3-HydroxytetrahydrofuranZ (S)-(+)-3-Hydroxytetrahydrofuran 99% (S)-(+)-3-Hydroxytetrahydrofuran, 98% colorless liquid (S)-(+)-3-Hydroxytetrahydrofuran, 98%, ee: 95% (S)-(+)-3-HYDROXYTETRAHYDROFURAN (S)-(+)-3-HYDROXYTETRAHYDROFURANE 3-FURANOL, TETRAHYDRO-, (S) (S)-(+)-3-HYDROXYTETRAHYDROFURAN, 99% (9 S-(+)-3-HYDROXYTETRAHYDROFURAN 98+% (S)-(+)-3-HYDOXY TETAHYDRO TETRAHYDRO FURAN (S)-3-Hydroxyterthydrofurane S-HYDROXYTETRAHYDROFURAN S-(+)-3-Hydroxytetrahydofuran (3S)-Tetrahydrofuran-3β-ol Oxolane-3β-ol (S)-(+)-3-Hydroxytetrahydrofuran,99% (S)-(+)-tetrahyro-3-furanol (S)-(+)-3-Hydroxytetrahydrofuran ,98% [ee:95%] (2S)-2-Hydroxy-1,4-epoxybutane (3S)-3-Hydroxytetrahydrofuran (3S)-(+)-3-Hydroxytetrahydrofuran 97+% (S)-(+)-3-HYDROXYTETRAHYDROFURAN, (9 (S)-(+)-3-Hydroxy-1,2,3,4-tetrahydrofuran S-3-hydroxytetrahydrofur (S)-3-hydroxytetyrahydrofurane S-3- Hydroxytetrafuran 3-Furanol, tetrahydro-, (3S)- (S)-(+)-3-HYDROXYTETRAHYDROFURAN (CAS NO.86087-23-2) (S)-Hydroxy THF (3S)-Tetrahydrofuran-3-ol,(3S)-Oxolan-3-ol (+)-3-Hydroxy-1,2,3,4-Tetrahydrofuran Empagliflozin Impurity 100 (S)-3-hydroxytetyrahydrofuran (+)-3-Hydroxytetrahydrofuran S-HTHF 2,4-Dichlorobenzyl Alcohol Impurity 10 (S)-(+)-3-Hydroxytetrahydrofuran (S)-(+)-3-Hydroxytetralydrofuran (S)-(+)-3-Hydroxytetrahydrofuran((S)-tetrahydrofuran-3-ol) (S)-Tetrahydrofuran-3-ol (Empagliflozin Impurity) (S)-(+)-3-Hydroxytetrahydrofuran Afatinib Int (S)-TETRAHYDROFURAN-3-OL (S)-3-HYDROXYTETRAHYDROFURAN (3S)-Tetrahydrofuran-3-ol 86087-23-2 86087-23-3 ALCOHOL Simple Alcohols (Chiral) Chiral Building Blocks Heterocyclic Building Blocks