1-Acetylpiperidin-4-amine
- CAS No.
- 160357-94-8
- Chemical Name:
- 1-Acetylpiperidin-4-amine
- Synonyms
- 4-Amino-N-1-acetylpiperidine;1-ACETYLPIPERIDIN-4-AMINE;4-Piperidinamine, 1-acetyl-;4-AMINO-1-ACETYL-PIPERIDINE;1-ACETYL-4-AMINO-PIPERIDINE;1-N-Acetyl-4-aminopiperidine;1-Acetyl-4-piperidinyl)amine;1-Acetyl-4-aminopiperidine 97%;1-Acetyl-4-aminopiperidine,>97%;1-(4-Aminopiperidino)-1-ethanone
- CBNumber:
- CB2146067
- Molecular Formula:
- C7H14N2O
- Molecular Weight:
- 142.2
- MDL Number:
- MFCD03412449
- MOL File:
- 160357-94-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 1-(4-Aminopiperidin-1-yl)ethan-1-one min. 95.0 % | A3613 | 200MG | $24 |
| 1-(4-Aminopiperidin-1-yl)ethan-1-one min. 95.0 % | A3613 | 1G | $84 |
| 1-Acetyl-4-aminopiperidine | A192255 | 50mg | $45 |
| 1-Acetylpiperidin-4-amine | FA75210 | 500mg | $90 |
| 1-Acetylpiperidin-4-amine | FA75210 | 1g | $140 |
| More product size | |||
| Boiling point | 273.6±33.0 °C(Predicted) |
|---|---|
| Density | 1.042±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | oil |
| pka | 9.37±0.20(Predicted) |
| color | Colourless to light yellow |
| InChI | InChI=1S/C7H14N2O/c1-6(10)9-4-2-7(8)3-5-9/h7H,2-5,8H2,1H3 |
| InChIKey | NLHBHVGPMMXWIM-UHFFFAOYSA-N |
| SMILES | C(=O)(N1CCC(N)CC1)C |
| CAS DataBase Reference | 160357-94-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | UN2735 |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 2933399990 |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
1-Acetylpiperidin-4-amine price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A3613 | 1-(4-Aminopiperidin-1-yl)ethan-1-one min. 95.0 % | 160357-94-8 | 200MG | $24 | 2026-03-19 | Buy |
| TCI Chemical | A3613 | 1-(4-Aminopiperidin-1-yl)ethan-1-one min. 95.0 % | 160357-94-8 | 1G | $84 | 2026-03-19 | Buy |
| TRC | A192255 | 1-Acetyl-4-aminopiperidine | 160357-94-8 | 50mg | $45 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA75210 | 1-Acetylpiperidin-4-amine | 160357-94-8 | 500mg | $90 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA75210 | 1-Acetylpiperidin-4-amine | 160357-94-8 | 1g | $140 | 2021-12-16 | Buy |
1-Acetylpiperidin-4-amine Chemical Properties,Uses,Production
Uses
1-Acetyl-4-aminopiperidine is a heterocyclic organic compound with a density of 1.042 g/cm3 and a boiling point of 273.6ºCat760 mmHg. It is an important intermediate in the synthesis of piperidine drugs.
Synthesis
135581-16-7
160357-94-8
General procedure for the synthesis of 4-amino-N-1-acetylpiperidine from 1-acetylpiperidin-4-one (CAS: 135581-16-7, 10 g, 70 mmol): 1. Oximization reaction: 1-acetylpiperidin-4-one was dissolved in 200 mL of ethanol, hydroxylamine hydrochloride (10 g, 143 mmol) and pyridine (10 mL) were added. The reaction mixture was heated to 70 °C and maintained for 1.5 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was treated with cold water and cooled to 0 °C. The resulting slurry was filtered and dried under vacuum to give 1-acetylpiperidin-4-one oxime (6.5 g, white solid, 59% yield). 2. Hydrogenation reaction: The oxime (2.0 g, 12 mmol) prepared above was dissolved in 50 mL of ethanol, and nickel ruanne (0.2 g) was added after being washed several times with water. The mixture was transferred to a Parr reactor and hydrogenated at 50 psi hydrogen pressure for 16 hours. Upon completion of the reaction, the reaction mixture was carefully filtered and the filtrate was evaporated under reduced pressure to afford 4-amino-N-1-acetylpiperidine (1.7 g, green solid, 100% yield). The product was analyzed by GC-MS, m/z = 142.
References
[1] Patent: WO2004/110996, 2004, A1. Location in patent: Page/Page column 102
[2] Patent: US2008/227780, 2008, A1. Location in patent: Page/Page column 55
1-Acetylpiperidin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
View Lastest Price from 1-Acetylpiperidin-4-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-06-19 | 1-Acetyl-4-amino-piperidine
160357-94-8
|
US $0.00-0.00 / kg | 1kg | 98% | kgs | Capot Chemical Co.,Ltd. | |
 |
2019-12-25 | 1-Acetylpiperidin-4-amine
160357-94-8
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 1-Acetyl-4-amino-piperidine
160357-94-8
- US $0.00-0.00 / kg
- 98%
- Capot Chemical Co.,Ltd.
-
- 1-Acetylpiperidin-4-amine
160357-94-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
