PPPDA-O16B
- CAS No.
- Chemical Name:
- PPPDA-O16B
- Synonyms
- PPPDA-O16B
- CBNumber:
- CB214906013
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
PPPDA-O16B Chemical Properties, Uses, Production
Description
PPPDA-O16B is a disulfide bond-containing ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for plasmid delivery in vitro and in vivo.1 LNPs containing PPPDA-O16B and encapsulating plasmids encoding Ras/Rap1-specific endopeptidase (RRSP) increase RRSP levels and decrease Ras levels in, and reduce the viability of, HeLa cervical cancer cells. LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart, liver, spleen, lungs, and kidneys, as well as decrease tumor volume without reducing body weight, in an HCT116 colorectal cancer mouse xenograft model.WARNING This product is not for human or veterinary use.
References
[1] LI W, SHAO L, LIU J, et al. Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticles†[J]. Biomaterials Science, 2023, 9: 3172-3179. DOI: 10.1039/d3bm00008g
PPPDA-O16B Preparation Products And Raw materials
Raw materials
Preparation Products
PPPDA-O16B Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cayman Chemical Company | -- | sales@caymanchem.com | China | 6808 | 58 |
| Neobioscience Co., Ltd. | -- | info@neobioscience.com | CHINA | 6192 | 58 |
| Supplier | Advantage |
|---|---|
| Cayman Chemical Company | 58 |
| Neobioscience Co., Ltd. | 58 |
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