Methyl 5-bromo-2-chloropyridine-3-carboxylate
- CAS No.
- 78686-79-0
- Chemical Name:
- Methyl 5-bromo-2-chloropyridine-3-carboxylate
- Synonyms
- METHYL 5-BROMO-2-CHLORONICOTINATE;methyl 2-chloro-5-bromonicotinate;Methyl5-Bromo-2-chloronicotinate>Methyl 5-bromo-2-chloronicotinate 98%;Methyl 5-broMo-2-chloronicotinate, 95+%;2-Chloro-5-bromonicotinic acid methyl ester;5-BROMO-2-CHLORONICOTINIC ACID METHYL ESTER;Methyl 5-bromo-2-chloropyridine-3-carboxlate;METHYL 5-BROMO-2-CHLOROPYRIDINE-3-CARBOXYLATE;methyl 5-bromo-2-chloro-3-pyridinecarboxylate
- CBNumber:
- CB2150790
- Molecular Formula:
- C7H5BrClNO2
- Molecular Weight:
- 250.48
- MDL Number:
- MFCD03844848
- MOL File:
- 78686-79-0.mol
- MSDS File:
- SDS
| Melting point | 50-52°C |
|---|---|
| Boiling point | 275.6±35.0 °C(Predicted) |
| Density | 1.684±0.06 g/cm3(Predicted) |
| Flash point | >110 °C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in Methanol |
| pka | -3.78±0.10(Predicted) |
| form | Solid |
| color | White to Light yellow to Light orange |
| Sensitive | Light, Air & Moisture Sensitive |
| InChI | InChI=1S/C7H5BrClNO2/c1-12-7(11)5-2-4(8)3-10-6(5)9/h2-3H,1H3 |
| InChIKey | MOMQDEDQGJAKII-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(Br)C=C1C(OC)=O |
| CAS DataBase Reference | 78686-79-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
Methyl 5-bromo-2-chloropyridine-3-carboxylate price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 764477 | Methyl 5-bromo-2-chloropyridine-3-carboxylate 97% | 78686-79-0 | 1g | $62.7 | 2023-06-20 | Buy |
| TCI Chemical | M2513 | Methyl 5-Bromo-2-chloronicotinate >98.0%(GC) | 78686-79-0 | 5g | $64 | 2025-07-31 | Buy |
| TRC | M295943 | Methyl 5-Bromo-2-chloronicotinate | 78686-79-0 | 250mg | $55 | 2021-12-16 | Buy |
| Matrix Scientific | 042788 | Methyl 5-bromo-2-chloronicotinate 95+% | 78686-79-0 | 25g | $59 | 2021-12-16 | Buy |
| AK Scientific | V0691 | Methyl 5-Bromo-2-chloronicotinate | 78686-79-0 | 25g | $67 | 2021-12-16 | Buy |
Methyl 5-bromo-2-chloropyridine-3-carboxylate Chemical Properties,Uses,Production
Crystal data
The crystal structure data of Methyl 5-bromo-2-chloropyridine-3-carboxylate is shown below:
Synthesis
Methyl 5-bromo-2-chloropyridine-3-carboxylate is prepared by the reaction of 5-Bromo-2-chloronicotinic acid and Methanol. The specific synthesis steps are as follows:
To 0.5 L flask charged with 5-Bromo-2-chloronicotinic acid (25.0 g, 106.4 mmol) in MeOH (250 mL) was added H2SO4(5 mL). The mixture was heated to 60° C., stirred for 1.5 day. LC-MS indicated full conversion of starting material at this time. The reaction was cooled to RT and the volatile components removed in vacuo. The crude residue was dissolved in EtOAc (300 mL), quenched with sat. aqueous Na(HCO3)2(200 mL). The organic layer was separated, washed with brine, dried over MgSO4and concentrated to afford the compound, methyl-5-bromo-2-chloronicotinate, as a while solid (quantitative yield). LC-MS (M+H)=250.1.
References
[1] Patent: US2012/172391, 2012, A1. Location in patent: Page/Page column 79
[2] Journal of Agricultural and Food Chemistry, 2016, vol. 64, # 18, p. 3533 - 3537
[3] Patent: WO2014/186398, 2014, A1. Location in patent: Page/Page column 49; 50; 51
[4] Patent: WO2017/120429, 2017, A1. Location in patent: Page/Page column 263
[5] Patent: US2012/178776, 2012, A1. Location in patent: Page/Page column 42-43
Methyl 5-bromo-2-chloropyridine-3-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29800 | 58 |
View Lastest Price from Methyl 5-bromo-2-chloropyridine-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-08-10 | Methyl 5-bromo-2-chloropyridine-3-carboxylate
78686-79-0
|
US $10.00 / kg | 1kg | 99.99% | 50000tons | Henan Bao Enluo International TradeCo.，LTD | |
 |
2021-10-26 | Methyl 5-bromo-2-chloropyridine-3-carboxylate
78686-79-0
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-07-02 | Methyl 5-bromo-2-chloropyridine-3-carboxylate
78686-79-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Methyl 5-bromo-2-chloropyridine-3-carboxylate
78686-79-0
- US $10.00 / kg
- 99.99%
- Henan Bao Enluo International TradeCo.，LTD
-
- Methyl 5-bromo-2-chloropyridine-3-carboxylate
78686-79-0
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 5-bromo-2-chloropyridine-3-carboxylate
78686-79-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
