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4-BROMO-2-HYDROXYACETOPHENONE

4-BROMO-2-HYDROXYACETOPHENONE structure

CAS No.: 30186-18-6

Chemical Name:: 4-BROMO-2-HYDROXYACETOPHENONE

Synonyms: 1-(4-Bromo-2-hydroxyphenyl)ethan-1-one;2-Acetyl-5-bromophenol;1-(4-Bromo-2-hydroxyphenyL;4-BROMO-2-HYDROXYACETOPHENONE;4'-Bromo-2'-hydroxyacetophenone;4-Bromo-2-hydroxyacetophenone ,97%;4'-Bromo-2'-hydroxyacetophenone,95%;4'-Bromo-2'-hydroxyacetophenone 98%;1-(4-BROMO-2-HYDROXY-PHENYL)-ETHANONE;ETHANONE, 1-(4-BROMO-2-HYDROXYPHENYL)-

CBNumber:: CB2154233

Molecular Formula:: C8H7BrO2

Molecular Weight:: 215.04

MDL Number:: MFCD03428533

MOL File:: 30186-18-6.mol

MSDS File:: SDS

Last updated:2025-08-08 17:45:00

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4-BROMO-2-HYDROXYACETOPHENONE Properties

Melting point	40.0 to 44.0 °C
Boiling point	83°C/7mmHg(lit.)
Density	1.586±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
form	Solid
pka	9.20±0.10(Predicted)
color	White to Yellow to Orange
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C8H7BrO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H3
InChIKey	LQCMMXGKEGWUIM-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=C(Br)C=C1O)C
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39

RIDADR

1759

HS Code

29143990

NFPA 704

	1
2		0

4-BROMO-2-HYDROXYACETOPHENONE price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B5382	4'-Bromo-2'-hydroxyacetophenone >98.0%(GC)(T)	30186-18-6	1g	$22	2025-07-31	Buy
TCI Chemical	B5382	4'-Bromo-2'-hydroxyacetophenone >98.0%(GC)(T)	30186-18-6	5g	$65	2025-07-31	Buy
TRC	B696240	1-(4-Bromo-2-hydroxyphenyl)ethanone	30186-18-6	100mg	$45	2021-12-16	Buy
TRC	B696240	1-(4-Bromo-2-hydroxyphenyl)ethanone	30186-18-6	500mg	$65	2021-12-16	Buy
American Custom Chemicals Corporation	HCH0012906	1-(4-BROMO-2-HYDROXYPHENYL)ETHANONE 95.00%	30186-18-6	1G	$708.48	2021-12-16	Buy

Product number	Packaging	Price	Buy
B5382	1g	$22	Buy
B5382	5g	$65	Buy
B696240	100mg	$45	Buy
B696240	500mg	$65	Buy
HCH0012906	1G	$708.48	Buy

4-BROMO-2-HYDROXYACETOPHENONE Chemical Properties,Uses,Production

Chemical Properties

White to yellow solid

Uses

4'-Bromo-2'-hydroxyacetophenone is used as a pharmaceutical intermediate.

Preparation

Preparation by diazotization of 5-amino-3-bromo-2- hydroxyacetophenone, followed by hydrolysis of the obtained diazonium salt (51%).

Synthesis

35065-86-2

30186-18-6

General procedure for the synthesis of 1-(4-bromo-2-hydroxyphenyl)ethanone from phenyl 3-bromoacetate: In a round-bottomed flask equipped with a reflux condenser, a nitrogen inlet, and a sodium hydroxide solution, aluminum chloride (36 g, 270 mmol) was slowly added to intermediate 9A (32.0 g, 149 mmol) to absorb the HCl gas generated. Water was generated during the reaction. The reaction flask was heated in an oil bath at 120°C. The reaction mixture gradually became fluid and was then slowly warmed to 165°C over a period of 1 hour and held at this temperature for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature. Approximately 200 mL of dichloromethane was added to the solid reaction mixture to form a slurry. The slurry was slowly poured into ice, a process that needed to be repeated several times to ensure complete treatment of the reaction mixture. The dichloromethane/water mixture was stirred until both phases became fairly clear, followed by phase separation. The organic phase was washed with brine, dried over anhydrous magnesium sulfate and finally concentrated under vacuum to give Intermediate 9B (30.14 g, 140 mmol, 94% yield) as a dark red oil. Mass spectrum (ESI) m/z 213,215.3 (M + H)+. The purity of the product was about 90%.

References

[1] Patent: US2009/202478, 2009, A1
[2] Patent: WO2007/37187, 2007, A1. Location in patent: Page/Page column 137
[3] Patent: WO2008/79836, 2008, A2. Location in patent: Page/Page column 96-97
[4] Synthesis (Germany), 2017, vol. 49, # 9, p. 1983 - 1992
[5] MedChemComm, 2013, vol. 4, # 11, p. 1434 - 1438

4-BROMO-2-HYDROXYACETOPHENONE synthesis

Synthesis of 4-BROMO-2-HYDROXYACETOPHENONE from Methylmagnesium Bromide and 4-BROMO-2-HYDROXYBENZONITRILE

4-BROMO-2-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Acetic anhydride Acetyl chloride Triethylamine Aluminum chloride Diethyl ether

Ethyl acetate Hydrochloric acid Dichloromethane Pyridine Magnesium sulfate

3-Bromophenol 4-BROMO-2-HYDROXYBENZONITRILE 1-(2-BroMo-4-Methoxy-phenyl)-ethanone 1-(4-bromo-2-methoxyphenyl)ethanone 3-BROMO-PHENYL ACETATE

Sulfuric acid Methylmagnesium Bromide

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Preparation Products

4-BROMO-2-HYDROXYACETOPHENONE Suppliers

Global( 215)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3944	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88299272	info@edengenechem.com	China	2176	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Synbest Biotech(Hangzhou) Co., Ltd	86-571-88737065	sales@synbestech.com	CHINA	170	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49730	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
Synbest Biotech(Hangzhou) Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from 4-BROMO-2-HYDROXYACETOPHENONE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-27	4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6	US $0.00 / KG	1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6	US $0.00-0.00 / KG	1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-07-18	4-BROMO-2-HYDROXYACETOPHENONE 30186-18-6	US $1.00 / KG	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd

4-BROMO-2-HYDROXYACETOPHENONE
30186-18-6
US $0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-BROMO-2-HYDROXYACETOPHENONE
30186-18-6
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

4-BROMO-2-HYDROXYACETOPHENONE
30186-18-6
US $1.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

4-BROMO-2-HYDROXYACETOPHENONE Spectrum

4-BROMO-2-HYDROXYACETOPHENONE(30186-18-6)¹HNMR

30186-18-6(4-BROMO-2-HYDROXYACETOPHENONE)Related Search:

5-BroMo-2-hydroxy-4-Methylacetophenone w-Bromo-4-Hydroxyacetophenone,OMEGA-BROMO-4-HYDROXYACETOPHENONE 5-Bromo-2-hydroxyacetophenone 2'-BROMO-4'-HYDROXYACETOPHENONE,2-BROMO-4'-HYDROXYACETOPHENONE,ALPHA-BROMO-4-HYDROXYACETOPHENONE,α-Bromo-4-hydroxyacetophenone,2-Bromo-4-Hydroxyacetophenone98% Disperse Blue 56

7-bromochroman-4-one 4-BROMO-2-HYDROXYACETOPHENONE Disperse Blue 81 1-Amino-2-bromo-4-hydroxy-9,10-anthraquinone 7-Bromo-4-oxo-4H-chromene-3-carbaldehyde

2-Bromo-2′-hydroxyacetophenone 4'-BROMO-2-HYDROXYACETOPHENONE 3',5'-Dibromo-4'-hydroxyacetophenone 3',5'-Dibromo-2'-hydroxyacetophenone 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE

4'-Bromoacetophenone 1-(4-BROMO-2-HYDROXYPHENYL)-1-PROPANONE N-BOC-7-BROMO-4-OXO-3,4-DIHYDRO-1''H-SPIRO[CHROMENE-2,4''-PIPERIDINE]

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ETHANONE, 1-(4-BROMO-2-HYDROXYPHENYL)- 4-BROMO-2-HYDROXYACETOPHENONE 1-(4-BROMO-2-HYDROXY-PHENYL)-ETHANONE 1-(4-Bromo-2-hydroxyphenyl)ethan-1-one 4-Bromo-2-hydroxyacetophenone ,97% 1-(4-Bromo-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-5-bromophenol 4'-Bromo-2'-hydroxyacetophenone 98% 1-(4-Bromo-2-hydroxyphenyL 4'-Bromo-2'-hydroxyacetophenone,95% 2-Acetyl-5-bromophenol 4'-Bromo-2'-hydroxyacetophenone 30186-18-6 Aromatic Acetophenones & Derivatives (substituted)