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Uridine 5′-monophosphate disodium salt

Uridine 5′-monophosphate disodium salt structure

CAS No.: 3387-36-8

Chemical Name:: Uridine 5′-monophosphate disodium salt

Synonyms: UMP DISODIUM SALT;5'-URIDYLIC ACID;URIDINE-5'-MONOPHOSPHATE DISODIUM;SodiuM ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl phosphate;UMP 2NA;UMP, NA2;NSC 20257;5'-UMP-NA2;5`-UMP,2Na;disodiumump

CBNumber:: CB2154253

Molecular Formula:: C9H14N2NaO9P

Molecular Weight:: 348.18

MDL Number:: MFCD00006525

MOL File:: 3387-36-8.mol

MSDS File:: SDS

Last updated:2026-04-17 13:05:51

Product description	Number	Pack Size	Price
Uridine 5′-monophosphate disodium salt ≥99%	U6375	1g	$58
Disodium 5′-uridylate United States Pharmacopeia (USP) Reference Standard	1222400	500mg	$404
Uridine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)	U0021	5g	$89
Uridine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)	U0021	25g	$246
Uridine 5′-monophosphate disodium salt ≥99%	U6375	5g	$138
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Uridine 5′-monophosphate disodium salt Properties

Melting point	208-210 °C
refractive index	-14 ° (C=1, H2O)
storage temp.	2-8°C
solubility	Water (Slightly)
form	Crystalline Powder
pka	6.4, 9.5(at 25℃)
color	White
biological source	(chemical)
Water Solubility	40 g/100 mL (20 ºC)
BRN	3582885
Stability	Very Hygroscopic
Cosmetics Ingredients Functions	SKIN CONDITIONING
InChI	InChI=1/C9H13N2O9P.Na.H/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18);;/t4-,6-,7-,8-;;/s3
InChIKey	KURVIXMFFSNONZ-WFIJOQBCSA-L
SMILES	O[C@@H]1[C@@H]([C@@H](COP(O)(O)=O)O[C@H]1N1C=CC(=O)NC1=O)O.[NaH] \|&1:1,2,3,11,r\|
CAS DataBase Reference	3387-36-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	KD8E20071T
UNSPSC Code	41116107
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H332-H302-H312

Precautionary statements

P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-24/25-36-26

WGK Germany

RTECS

YU7975000

10-21

HS Code

29389090

Storage Class

11 - Combustible Solids

NFPA 704

	0
0		0

Uridine 5′-monophosphate disodium salt price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	U6375	Uridine 5′-monophosphate disodium salt ≥99%	3387-36-8	1g	$58	2026-03-19	Buy
Sigma-Aldrich	1222400	Disodium 5′-uridylate United States Pharmacopeia (USP) Reference Standard	3387-36-8	500mg	$404	2026-03-19	Buy
TCI Chemical	U0021	Uridine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)	3387-36-8	5g	$89	2026-03-19	Buy
TCI Chemical	U0021	Uridine 5'-Monophosphate Disodium Salt Hydrate >98.0%(HPLC)	3387-36-8	25g	$246	2026-03-19	Buy
Sigma-Aldrich	U6375	Uridine 5′-monophosphate disodium salt ≥99%	3387-36-8	5g	$138	2026-03-19	Buy

Product number	Packaging	Price	Buy
U6375	1g	$58	Buy
1222400	500mg	$404	Buy
U0021	5g	$89	Buy
U0021	25g	$246	Buy
U6375	5g	$138	Buy

Uridine 5′-monophosphate disodium salt Chemical Properties,Uses,Production

Chemical Properties

The protonation of disodium Uridine 5′-monophosphate disodium salt and cytidine 5' -monophosphate (a homolog of UMP) not only depend on the electrostatic forces but also strongly depend on the solute–solvent interactions of the different species in the mixtures. In the case of UMP, the correlation analysis of log10 K2 and log10 K1 (including β and π*) shows the polarity parameter has a major role (about 58 and 56 %, respectively) and the negative sign of π* and positive sign of β indicate that a decrease in the polarity of the media increases the protonation constants[1].

Uses

Uridine 5'-monophosphate disodium salt （UMP-Na2） is a major component of RNA, a nucleotide. It is found in dietary supplements as well as in natural foods rich in RNA and has been shown to enhance cognitive function in animals.

Uses

Uridine 5’-Monophosphate Disodium Salt is a derivative of Uridine (U829910) which is a major ribonucleic acid.

Uses

Uridine 5′-monophosphate disodium salt has been used to study the effect of pyrimidine synthesis inhibitor, 5-azacytidine, on cholesterol and lipid metabolism. It has been used to study the effect of nucleotides on growth of specific intestinal bacteria.

Application

Uridine 5′-monophosphate disodium salt can be used as a cross-linking agent to prepare thermosensitive chitosan hydrogels containing graphene oxide as nanofillers. The hydrogels are attractive materials for use as scaffolds for the regeneration of damaged tissues[3].

benefits

Membrane phospholipids like phosphatidylcholine (PC) are required for cellular growth and repair, specifically for synaptic function. PC synthesis is controlled by cellular levels of its precursor, cytidine-5'-diphosphate choline (CDP-choline), which is produced from cytidine triphosphate (CTP) and phosphocholine. In rat PC12 cells, exogenous uridine was shown to elevate intracellular CDP-choline levels by promoting the synthesis of uridine triphosphate (UTP), which was partly converted to CTP. In such cells, uridine also enhances the neurite outgrowth produced by the nerve growth factor (NGF). A study assessed the effect of dietary supplementation with uridine-5'-monophosphate disodium (UMP-2Na+, an additive in infant milk formulas) on striatal dopamine (DA) release in aged rats. Potassium (K+)-evoked DA release was significantly greater among UMP-treated rats, i.e., 341+/-21% of basal levels vs. 283+/-9% of basal levels in control rats (p<0.05); basal DA release was unchanged. The levels of neurofilament-70 and neurofilament-M proteins, biomarkers of neurite outgrowth, increased to 182+/-25% (p<0.05) and 221+/-34% (p<0.01) of control values, respectively, with UMP consumption. Hence, UMP treatment not only enhances membrane phosphatide production but also can modulate two membrane-dependent processes, neurotransmitter release and neurite outgrowth, in vivo[2].

General Description

Uridine 5′-monophosphate is a pyrimidine mononucleotide. It is formed by decarboxylation of orotidine 5′-monophosphate. UMP is further converted to UTP (uridine 5′-triphosphate) using kinases.

References

[1] Soleimani, Farahnaz, and F. Gharib. "Protonation Constants of Uridine 5′-Monophosphate in Different Aqueous Solutions of Methanol." Journal of Solution Chemistry 43.4(2014):763-773.
[2] Lei Wang. “Dietary uridine-5′-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats.” Journal of Molecular Neuroscience 27 1 (2005): 137–145.
[3] KATARZYNA PIEKLARZ. Nanoarchitectonics and Biological Properties of Nanocomposite Thermosensitive Chitosan Hydrogels Obtained with the Use of Uridine 5’-Monophosphate Disodium Salt.[J]. International Journal of Molecular Sciences, 2024. DOI:10.3390/ijms25115989.

Uridine 5′-monophosphate disodium salt synthesis

Synthesis of Uridine 5′-monophosphate disodium salt from Adenosine 5'-monophosphate disodium salt

Uridine 5′-monophosphate disodium salt Preparation Products And Raw materials

Raw materials

Ribonucleic acid Nuclease Sodium hydroxide

Preparation Products

Uridine 5′-monophosphate disodium salt Suppliers

Global( 621)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Meiya Pharmaceutical Co Ltd	+86-021-33686691 +86-18001850931	sales@meiyapharm.com	China	58	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	8616	58
Xinxiang Aurora Biotechnology Co.,Ltd.	+86-0086-0373-3088722 +8618637352520	info@aurora-biotech.com	China	118	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou)	+86-57182358004 13588810720	sales1@weitai-pharmaceutical.com	China	61	58
Watson Biotechnology Co.,Ltd	+86-18186686046 +86-18186686046;	sales01@watsonbiotech.cn	China	5738	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3996	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +8615350851019	admin@86-ss.com	China	999	58

Supplier	Advantage
Hangzhou Meiya Pharmaceutical Co Ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Xinxiang Aurora Biotechnology Co.,Ltd.	58
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou)	58
Watson Biotechnology Co.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hangzhou ICH Biofarm Co., Ltd	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58

View Lastest Price from Uridine 5′-monophosphate disodium salt manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	Disodium uridine-5'-monophosphate 3387-36-8	US $0.00-0.00 / Kg/Drum	1KG	98%min	1000KG	WUHAN FORTUNA CHEMICAL CO., LTD
2026-04-17	Uridine 5′-monophosphate disodium salt 3387-36-8	US $1000.00-400.00 / kg	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-04-17	Uridine 5'-monophosphate disodium salt 3387-36-8	US $29.00 / g		99.55%	10g	TargetMol Chemicals Inc.

Disodium uridine-5'-monophosphate
3387-36-8
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Uridine 5′-monophosphate disodium salt
3387-36-8
US $1000.00-400.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Uridine 5'-monophosphate disodium salt
3387-36-8
US $29.00 / g
99.55%
TargetMol Chemicals Inc.

Uridine 5′-monophosphate disodium salt Spectrum

Uridine 5′-monophosphate disodium salt(3387-36-8)¹HNMR Uridine 5′-monophosphate disodium salt(3387-36-8)³¹PNMR Uridine 5′-monophosphate disodium salt(3387-36-8)¹³CNMR Uridine 5′-monophosphate disodium salt(3387-36-8)IR1 Uridine 5′-monophosphate disodium salt(3387-36-8)IR2 Uridine 5′-monophosphate disodium salt(3387-36-8)Raman

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3'-UMP NA Uridine 5'-monophosphate Citric acid

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5'-URIDYLIC ACID DISODIUM SALT 5'-UMP-NA2 U 5'-P DISODIUM SALT UMP 2NA UMP DISODIUM UMP, NA2 URIDINE-5'-MONOPHOSPHORIC ACID, DISODIUM URIDINE 5'-MONOPHOSPHORIC ACID DISODIUM SALT 5’-umpdisodium disodium5’-ump disodium5’-uridylate disodiumump disodiumuridine5’-phosphate uridine,5’-dihydrogenphosphate,disodiumsalt 5`-UMP,2Na Uridine-5'-phosphoric acid disodium salt URIDINE-5'-MONOPHOSPHATE, DISODIUM SALT 98-100% Disodium uridine-5'-monophosphate Uridylic acid disodium salt Uridine-5''-monophosphate disodium (from yeast) Uridine-5’-Monophosphate(UMP),2Na UMP,Uridylic acid disodium salt URIDINE-5'-MONOPHOSPHATE DISODIUM SALT DIHYDRATE extrapure 5μ-UMP-Na2, U 5μ-P, UMP, Uridylic acid disodium salt Disodium 5’-uridilate Uridine 5'-monophosphate, disodium salt, food grade Uridine 5′-monophosphate disodium salt U 5′-P 5'-UMP Uridylic acid disodium salt Uridine -5'- Monophosphate Disodium Salt（UMP- Na2） Uridine-5-monophospahte disodium Salt Ump:Uridine-5-MonophosphateDisodiumSalt Uridine 5'-phosphate disodium salt Uridine 5'-monophosphate, disodium salt, hydrate,98% URIDINE-5'-MONOPHOSPHATE DISODIUM SALT(SH) Uridine-5'-monophosphate[UMP],disodium salt Uridine 5′-monophosphate disodium salt,5′-UMP-Na2, U 5′-P, UMP, Uridylic acid disodium salt Uridine-5'-phosphori 5'-UMPNa2(Uridine 5'-dihydrogen phosphate,disodium salt) SodiuM ((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl phosphate URIDINE-5'-MONOPHOSPHATE DISODIUM SALT(P) Disodium 5'-Uridylate (500 mg) NSC 20257 (2'/3')-UMP Na DisodiuM (2'/3')-UMP 5'-Uridylic Acid Disodium Salt 5'-UMP 2Na 5'-Uridylic acid,sodiuM salt (1:2) Disodium uridine-5'-monophosphate Solution, 100μg/mL DISODIUM URIDINE-5’-MONOPHOSPHATE(UMP) Disodium uridine-5'-monophosphate USP/EP/BP Uridine -5- disodium Monophosphate Diquafosol Sodium Impurity B Uridine 5-Monophosphate Disodium Salt Hydrate (5-UMP-Na2) extrapure, 98.5% 17α-Hydroxyprogesterone hexanoate Disodium 5' -uridine Diquafosol Impurity-UMP 5′-UMP-Na2 (UMP) Uridine 5’- Monophosphate Disodium Salt (5`-UMPNa2) Uridine 5'-Monophosphate Disodium Salt ·X Hydrate Uridine-5-Monophsophate Disodium Salt Dihydrate