CASPASE-1
- CAS No.
- 122191-40-6
- Chemical Name:
- CASPASE-1
- Synonyms
- ICE;CASP-1;IL-1BC;IL1BCE;CASPASE-1;ICE 1B HUMAN;P45) USP/EP/BP;CASPASE 1 HUMAN;Casp1 Il1bc Il1bce;IL-1 β converting enzyme
- CBNumber:
- CB2155407
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD02677921
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| Anti-CASP1, C-Terminal antibody produced in rabbit affinity isolated antibody | SAB4503271 | 100μG | $560 |
| Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit affinity isolated antibody | SAB4503272 | 100 μg | $522 |
| Caspase-1, Human, Recombinant, E. coli Caspase-1, Human, Recombinant, is expressed in E. coli and is fused at the N-terminus to a Hi | 218783 | 3000 U | $622 |
| Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit affinity isolated antibody | SAB4503272 | 100μG | $506 |
| Caspase-1, Human, Recombinant, E. coli | 218783 | 3000u | $604 |
| storage temp. | −70°C |
|---|---|
| form | powder |
| biological source | rabbit |
| Specific Activity | ≥5000units/mg protein |
| NCI Dictionary of Cancer Terms | ICE |
| FDA UNII | GTI4HE0N2F |
| UNSPSC Code | 12352204 |
| NACRES | NA.77 |
CASPASE-1 price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB4503271 | Anti-CASP1, C-Terminal antibody produced in rabbit affinity isolated antibody | 122191-40-6 | 100μG | $560 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB4503272 | Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit affinity isolated antibody | 100 μg | $522 | 2025-07-31 | Buy | |
| Sigma-Aldrich | 218783 | Caspase-1, Human, Recombinant, E. coli Caspase-1, Human, Recombinant, is expressed in E. coli and is fused at the N-terminus to a Hi | 3000 U | $622 | 2025-07-31 | Buy | |
| Sigma-Aldrich | SAB4503272 | Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit affinity isolated antibody | 122191-40-6 | 100μG | $506 | 2024-03-01 | Buy |
| Sigma-Aldrich | 218783 | Caspase-1, Human, Recombinant, E. coli | 122191-40-6 | 3000u | $604 | 2024-03-01 | Buy |
CASPASE-1 Chemical Properties,Uses,Production
Uses
Caspase 1 human has been used in in vitro cleavage assay with Rab interacting lysosomal protein (RILP) and in the cleavage of caspases-3/7 in human monocyticcells (THP1).
General Description
Caspase 1, also called interleukin (IL)-1-converting enzyme, is mapped to human 11q22.3. It belongs to the aspartate-specific cysteine proteases family and is primarily synthesized as procaspase-1 zymogen, which later become catalytically active post autoproteolysis. The enzymatically active caspase-1 comprises two p20/p10 heterodimer making it a tetramer.
Biochem/physiol Actions
Caspase 1 catalyzes the conversion of pro-inflammatory cytokine, pro-interleukin (IL)-1β to its active form. It has broad substrate specificity and is an apoptosis regulator. Caspase-1 is indirectly implicated in the pathology of cryopyrin-associated periodic syndrome (CAPS). It is a multiple inflammasome-associated protein associated with multiple sclerosis (MS) lesions and is a prime target for inhibitor screening.
CASPASE-1 Preparation Products And Raw materials
Raw materials
Preparation Products
CASPASE-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Nippon Gases Deutschland GmbH | +49 211 2600-0 | info.germany@nippongases.com | Germany | 1 | 58 |
| Air Liquide B.V. | +31 20 795 6621 | nlics-customerservice@airliquide.com | The Netherlands | 2 | 58 |
| Nippon Gases Netherlands B.V. | +31 10 434 04 55 | info.netherlands@nippongases.com | The Netherlands | 2 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25021 | 58 |
| Shanghai Yaji Biological Technology Co., Ltd. | 021-34661275 15301693058 | yajikit@163.com | China | 9917 | 58 |
| Kamiya Biomedical Company | 1-+1 206-575-8068 1206-575-8068 | ordering@k-assay.com | China | 928 | 58 |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | Enzoname@qq.com | China | 6174 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Shanghai Jinshi Biochemical Technology Co., Ltd | 18601717983 18601717983 | 291017736@qq.com | China | 499 | 58 |
