Description
Δ2 α-Tubulin is a non-tyrosinatable variant of tubulin that lacks a carboxy-terminal glutamyl-tyrosine group on its α-subunit.1,2 It is expressed in a wide variety of cell types, including fibroblasts and adrenal cortical cells, and accounts for approximately 35% of brain tubulin. Δ2 α-Tubulin is primarily localized to stable cellular structures such as centrosomes and primary cilia, however, it localizes to microtubule bundles and paracrystalline bundles following cellular exposure to paclitaxel or vinblastine, respectively.1 It is also subject to post-translational modifications, including glutamylation, and levels of glutamylated Δ2 α-tubulin are increased in mouse models of acute epileptic seizure and slow-developing Alzheimer’s disease.3 Cayman’s Δ2 α-Tubulin Rabbit Monoclonal Antibody (Clone RM447) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.WARNING This product is not for human or veterinary use.
