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1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE structure

CAS No.: 54125-02-9

Chemical Name:: 1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE

Synonyms: DK814;DKSI071;DANISHEFSKY'S DIENE;Danishefsky-Kitahara diene.;1-METHOXY-3-(TRIMETHYLSILOXY)BUTADIENE;TRANS-1-METHOXY-3-TRIMETHYLSILOXY- &;1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE;1-METHOXY-3-TRIMETHYLSILYLOXY-1,3-BUTADIENE;1-Methoxy-3-trimethylsiloxy-1,3-butadiene ,95%;1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE, 98+%

CBNumber:: CB2162111

Molecular Formula:: C8H16O2Si

Molecular Weight:: 172.3

MDL Number:: MFCD00008498

MOL File:: 54125-02-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:09

Product description	Number	Pack Size	Price
trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene 95%	212830	1g	$65.7
trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene 95%	212830	5g	$209
TRANS-1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE 95.00%	ORS0000837	5ML	$945.95
1-Methoxy-3-trimethylsiloxy-1,3-butadiene	X3432	1g	$137
TRANS-1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE 95.00%	ORS0000837	1G	$149.52
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1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE Properties

Boiling point	68-69 °C/14 mmHg (lit.)
Density	0.885 g/mL at 25 °C (lit.)
refractive index	n20/D 1.454(lit.)
Flash point	113 °F
storage temp.	2-8°C
form	liquid
Specific Gravity	0.89
Appearance	Colorless to light yellow Liquid
Water Solubility	Miscible with most organic solvents. Immiscible with water.
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Merck	14,6001
BRN	1616761
InChI	1S/C8H16O2Si/c1-8(6-7-9-2)10-11(3,4)5/h6-7H,1H2,2-5H3/b7-6+
InChIKey	SHALBPKEGDBVKK-VOTSOKGWSA-N
SMILES	CO\C=C\C(=C)O[Si](C)(C)C
CAS DataBase Reference	54125-02-9(CAS DataBase Reference)
FDA UNII	1ZOR63U51O
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02

Signal word

Warning

Hazard statements

H226

Precautionary statements

P210-P233-P240-P241-P242-P243

PPE

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Risk Statements

Safety Statements

23-24/25

RIDADR

UN 1993 3/PG 3

WGK Germany

10-21

TSCA

HazardClass

PackingGroup

III

HS Code

2931900090

Storage Class

3 - Flammable liquids

Hazard Classifications

Flam. Liq. 3

NFPA 704

	2
1		0

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	212830	trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene 95%	54125-02-9	1g	$65.7	2026-03-19	Buy
Sigma-Aldrich	212830	trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene 95%	54125-02-9	5g	$209	2026-03-19	Buy
American Custom Chemicals Corporation	ORS0000837	TRANS-1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE 95.00%	54125-02-9	5ML	$945.95	2021-12-16	Buy
AK Scientific	X3432	1-Methoxy-3-trimethylsiloxy-1,3-butadiene	54125-02-9	1g	$137	2021-12-16	Buy
American Custom Chemicals Corporation	ORS0000837	TRANS-1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE 95.00%	54125-02-9	1G	$149.52	2021-12-16	Buy

Product number	Packaging	Price	Buy
212830	1g	$65.7	Buy
212830	5g	$209	Buy
ORS0000837	5ML	$945.95	Buy
X3432	1g	$137	Buy
ORS0000837	1G	$149.52	Buy

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE Chemical Properties,Uses,Production

Uses

1-Methoxy-3-trimethylsiloxy-1,3-butadiene is employed as a reagent in Mannich-Michael reaction for the synthesis of piperidinones and enaminones. As Diels-Alder diene, it is used in the synthesis of pyridones and pyranones, sulfone analogues of griseofulvin (sulfogriseofulvins) and 4H-1-aminopyrroles and 4, 5H-pyrazoles.

General Description

trans-1-methoxy-3-trimethylsiloxy-1,3-butadiene is a funtionalized Diels-Alder diene. Mukaiyama-Michael-type addition/heterocyclization of trans-1-methoxy-3-trimethylsiloxy-1,3-butadiene (Danishefsky′s diene) with 1,2-diaza-1,3-butadiene has been investigated. Asymmetric hetero-Diels-Alder cyclization of Danishefsky′s diene with benzaldehyde catalyzed by mesoporous inorganic/metalorganic hybrid materials has been reported.

Purification Methods

It may contain up to 1% of the precursor 4-methoxybut-4-ene-2-one. It is easily purified by distilling through a Vigreux column (p 11) in a vacuum and taking the middle fraction. [Danishefsky & Kitihara J Am Chem Soc 96 7807 1974, Danishefsky Acc Chem Res 14 400 1981.]

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE synthesis

Synthesis of 1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE from Chlorotrimethylsilane and 4-METHOXY-3-BUTEN-2-ONE

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE Preparation Products And Raw materials

Raw materials

Sodium acetate Acetonitrile Acetylacetaldehyde dimethyl acetal Lithium bromide Chlorotrimethylsilane

Sodium Zinc chloride Triethylamine Sodium iodide Diethyl ether

Benzene 4-METHOXY-3-BUTEN-2-ONE Trimethylsilyl trifluoromethanesulfonate

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Preparation Products

5-Hydroxybenzo[b]furan 2H-Pyran-4(3H)-one 4-METHOXY-3-BUTEN-2-ONE 4H-Pyran-4-one, 2,3-dihydro-2-[(phenylmethoxy)methyl]-

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE Suppliers

Global( 106)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30227	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52705	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20405	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	24597	58

Supplier	Advantage
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Career Henan Chemica Co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Alfa Chemistry	58
HANGZHOU LEAP CHEM CO., LTD.	58

View Lastest Price from 1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-17	1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE 54125-02-9	US $3.00-9.00 / KG	0.1KG	99%	g-kg-tons, free sample is available	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2025-12-01	1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE 54125-02-9	US $0.00-0.00 / KG	1KG	95.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE
54125-02-9
US $3.00-9.00 / KG
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE
54125-02-9
US $0.00-0.00 / KG
95.0%
Shaanxi Dideu New Materials Co. Ltd

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE Spectrum

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE(54125-02-9)¹HNMR 1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE(54125-02-9)IR 1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE(54125-02-9)FT-IR 1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE(54125-02-9)Raman

54125-02-9(1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE)Related Search:

Triethoxysilane Octamethylcyclotetrasiloxane Vinyltrimethoxysilane 4-Methoxy-2-(trimethylsiloxy)-1,3-butadiene,1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE,TRANS-1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE ALLYLOXYTRIMETHYLSILANE

Ethoxytrimethylsilane 2-(Trimethylsiloxy)-1,3-butadiene METHOXYTRIMETHYLSILANE DIMETHYLETHOXYSILANE VINYLOXYTRIMETHYLSILANE

1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE ISOPROPENYLOXYTRIMETHYLSILANE 1-METHOXY-1,3-BUTADIENE DIMETHYLMETHOXYSILANE Silane, methoxy-

TRANS-3-(TERT-BUTYLDIMETHYLSILYLOXY)-1-METHOXY-1,3-BUTADIENE (E,Z)-1-Methoxy-2-methyl-3- (trimethylsilyloxy)-1,3-pentadiene (1Z)-1-(Benzyloxy)-3-methoxy-1-(trimethylsiloxy)-1,3-butadiene

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TRANS-1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE TRANS-1-METHOXY-3-(TRIMETHYLSILYLOXY)-1,3-BUTADIENE DANISHEFSKY'S DIENE 1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE 1-METHOXY-3-(TRIMETHYLSILOXY)BUTADIENE 1-METHOXY-3-TRIMETHYLSILYLOXY-1,3-BUTADIENE TRANS-1-METHOXY-3-TRIMETHYLSILOXY- & 1-Methoxy-3-(trimethylsiloxy)butadiene(Danishefsky`sDiene) Silane, (2E)-3-methoxy-1-methylene-2-propenyloxytrimethyl- Danishefsky-Kitahara diene. 1-METHOXY-3-TRIMETHYLSILOXY-1,3-BUTADIENE, 98+% 1-Methoxy-3-trimethylsiloxy-1,3-butadiene ,95% (1E)-3-(Trimethylsilyloxy)-1-methoxy-1,3-butadiene (E)-1-Methoxy-3-(trimethylsiloxy)-1,3-butadiene (E)-1-Methoxy-3-[(trimethylsilyl)oxy]-1,3-butadiene [[(E)-3-Methoxy-1-methylene-2-propenyl]oxy]trimethylsilane Methyl[(1E)-3-(trimethylsiloxy)-1,3-butadienyl] ether (E)-(4-methoxybuta-1,3-dien-2-yloxy)trimethylsilane [(E)-3-Methoxy-1-methylene-allyloxy]-trimethyl-silane trans-1-Methoxy-3-trimethylsilyloxy-1,3-butadiene for synthesis trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene,Danishefsky’s diene Silane, [[(2E)-3-Methoxy-1-Methylene-2-propen-1-yl]oxy]triMethyl- [(4-Methoxybuta-1,3-dien-2-yl)oxy]triMethylsilane trans-1-Methoxy-3-triMethylsiloxy-1,3-butadiene 95% (2E)-3-Methoxy-1-methylene-2-propen-1-yl]oxy]trimethylsilane DK814 DKSI071 trans-1-Methoxy-3-trimethylsiloxy-1,3-butadiene (2E)-3-Methoxy-1-methylene-allyl]oxy]trimethylsilane 54125-02-9 C8H16O2Si1 CH33SiOCCH2CHCHOCH3 Building Blocks Enol Ethers Organic Building Blocks Oxygen Compounds Si-O Compounds Silicon Compounds (for Synthesis) Monoalkoxysilanes Si (Classes of Silicon Compounds) Vinylsilanes, Allylsilanes