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ChemicalBook >> CAS DataBase List >>1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Structure
1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL structure
CAS No.
86215-36-3
Chemical Name:
1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL
Synonyms
CL216303;CL-216303;CL 216303;DOV216303 HCl;CL-216303 HCl;CL216303 HCl,CL 216303 HCl;1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL;1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hychloride;1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride
CBNumber:
CB2164988
Molecular Formula:
C11H12Cl3N
Molecular Weight:
264.58
MDL Number:
MFCD06407666
MOL File:
86215-36-3.mol
Last updated:2025-07-20 09:44:47
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1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Properties

storage temp. -20°C
solubility DMSO: ≥10mg/mL
form powder
color white to beige
CAS DataBase Reference 86215-36-3
FDA UNII 06S4712H0T
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H319
Precautionary statements  P301+P310+P330-P305+P351+P338
Hazard Codes  T
Risk Statements  25-36
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D6446 DOV 216,303 ≥98% (HPLC) 86215-36-3 5mg $132 2025-07-31 Buy
Sigma-Aldrich D6446 DOV 216,303 ≥98% (HPLC) 86215-36-3 25mg $443 2025-07-31 Buy
Activate Scientific AS58986 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane HCl 95+% 86215-36-3 1g $425 2021-12-16 Buy
ACHEMBLOCK L13151 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexanehydrochloride 97% 86215-36-3 5G $1245 2021-12-16 Buy
ACHEMBLOCK L13151 1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexanehydrochloride 97% 86215-36-3 1G $365 2021-12-16 Buy
Product number Packaging Price Buy
D6446 5mg $132 Buy
D6446 25mg $443 Buy
AS58986 1g $425 Buy
L13151 5G $1245 Buy
L13151 1G $365 Buy

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Chemical Properties,Uses,Production

Uses

DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].

Biological Activity

Triple reuptake inhibitor (TRI); serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI); IC50 values of ~20, 14, and 78 nM, respectively.

References

[1] Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. DOI:10.1111/j.1527-3458.2006.00123.x
[2] Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. DOI:10.1016/j.bmcl.2011.01.016
[3] Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61. DOI:10.1095/biolreprod44.3.561

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Preparation Products And Raw materials

Raw materials

Preparation Products

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Suppliers

Global( 18)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
Aikon International Limited 025-66061636 18013972705 qqyang@aikonchem.com China 15815 58
Bejing Famous Pharmaceutical Technology Co., Ltd. 010-80339217; 15811073878 1963319514@qq.com China 14213 58
CHENGDU JINMAIRUI BIO-TECHNOLOGY CO.LTD 028-83133020 18280298385 1223808415@qq.com China 511 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24982 58
Merck KGaA 21-20338288 ordercn@merckgroup.com China 6394 58
Synthonix Inc -- info@synthonix.com United States 6872 58
Guangzhou Yanna Biotechnology Co., Ltd. 15994750751 CHINA 0 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Aikon International Limited 58
Bejing Famous Pharmaceutical Technology Co., Ltd. 58
CHENGDU JINMAIRUI BIO-TECHNOLOGY CO.LTD 58
TargetMol Chemicals Inc. 58
Merck KGaA 58
Synthonix Inc 58
Guangzhou Yanna Biotechnology Co., Ltd. 58

View Lastest Price from 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CL-216303 HCl pictures 2025-07-20 CL-216303 HCl
86215-36-3
 US $1980.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • CL-216303 HCl pictures
  • CL-216303 HCl
    86215-36-3
  • US $1980.00-1520.00 / mg
  • TargetMol Chemicals Inc.

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL Spectrum

1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL(86215-36-3)1HNMR

86215-36-3(1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL)Related Search:

3-(4-chlorophenyl)piperidine C-[1-(4-CHLORO-PHENYL)-CYCLOPROPYL]-METHYLAMINE 1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL cyclopropyl(phenyl)methanamine C-[1-(3-CHLORO-PHENYL)-CYCLOPROPYL]-METHYLAMINE
1-(3,4-DICHLORO-PHENYL)-3-AZA-BICYCLO[3.1.0]HEXANE HCL 1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hydrochloride 1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane hychloride DOV216303 HCl CL 216303 CL216303 CL-216303 CL-216303 HCl CL216303 HCl,CL 216303 HCl 86215-36-3 C11H12Cl3N C11H11Cl2NHCl C11H11Cl2NClH pharmacetical