ChemicalBook >> CAS DataBase List >>Boldine
Boldine
- CAS No.
- 476-70-0
- Chemical Name:
- Boldine
- Synonyms
- boldin;(s)-yl;BOLDINE;BOLDINE(RG);(s)-boldine;Boldine CRS;(+)-boldine;(+)-(s)-boldine;ex Peumus boldus;boldine--chloroform
- CBNumber:
- CB2167570
- Molecular Formula:
- C19H21NO4
- Molecular Weight:
- 327.37
- MDL Number:
- MFCD00135040
- MOL File:
- 476-70-0.mol
Last updated:2025-09-22 15:06:41
| Melting point | 162-164 °C |
|---|---|
| Boiling point | 465.27°C (rough estimate) |
| Density | 1.2223 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | 2-8°C |
| solubility | Acetonitrile (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly) |
| form | Solid |
| pka | 9.75±0.20(Predicted) |
| color | Yellow to Dark Brown |
| Merck | 13,1316 |
| BRN | 94036 |
| LogP | 0.837 (est) |
| CAS DataBase Reference | 476-70-0(CAS DataBase Reference) |
| FDA UNII | 8I91GE2769 |
| EPA Substance Registry System | 4H-Dibenzo[de,g]quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl-, (6aS)- (476-70-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 1-20-24/25-45-36-26 | |||||||||
| RIDADR | 1544 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CE0750000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29399990 | |||||||||
| NFPA 704 |
|
Boldine price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002060 | Boldine for system suitability European Pharmacopoeia (EP) Reference Standard | 476-70-0 | 20 mg | $118 | 2025-07-31 | Buy |
| Sigma-Aldrich | Y0000434 | Boldine European Pharmacopoeia (EP) Reference Standard | 476-70-0 | 30 mg | $156 | 2025-07-31 | Buy |
| Sigma-Aldrich | B3916 | Boldine analytical standard | 476-70-0 | 1g | $21.7 | 2022-05-15 | Buy |
| Cayman Chemical | 18447 | Boldine ≥95% | 476-70-0 | 1g | $25 | 2024-03-01 | Buy |
| Cayman Chemical | 18447 | Boldine ≥95% | 476-70-0 | 5g | $94 | 2024-03-01 | Buy |
Boldine Chemical Properties,Uses,Production
Uses
antineoplastic
Uses
boldine is attributed with strong anti-oxidant properties. It has also demonstrated an ability to protect against uVB rays. Boldine is a constituent of the boldo plant (Peumus boldus Mol.) native to Chile, and is found in the plant’s leaves and bark.
Definition
ChEBI: Boldine is an aporphine alkaloid.
in vivo
Boldine (50 mg/kg, p.o, for 7 days) attenuates Dextran Sulfate Sodium (DSS) -induced colitis in mice via p65-NF-κB and STAT3 signaling pathways[3].
| Animal Model: | DSS-induced mice model[3] |
| Dosage: | 50 mg/kg |
| Administration: | p.o. |
| Result: | Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO) Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA) Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity. |
Boldine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 188)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3565 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32431 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9629 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39031 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
View Lastest Price from Boldine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-22 | Boldine
476-70-0
|
US $35.00-44.00 / mg | 98.53% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-08-05 | Boldine
476-70-0
|
US $1.00-45.00 / KG | 1KG | 99% | 420000KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | Boldine
476-70-0
|
US $1.00 / KG | 1g | 99% | 100KG | Career Henan Chemical Co |
(+)-(s)-boldine
(s)-boldine
(s)-yl
1,10-dimethoxy-6a-alpha-aporphine-2,9-diol
1,10-dimethoxy-6a-alpha-aporphine-9-diol
4h-dibenzo(de,g)quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-meth
4h-dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-dimethoxy-6-methyl
boldin
boldine--chloroform
BOLDINE(RG)
BOLDINE
BOLDO STANDARD EXTRACT
2 6-DIHYDROXY-3 5-DIMETHOXYAPORPHIN
2,9-DIHYDROXY-1,10-DIMETHOXYAPORPHINE
1,10-DIMETHOXY-2,9-DIHYDROXYAPORPHINE
2,9-Dihydroxy-1,10-dimethoxyaporphine, Boldine
(-)-6-Methyl-1,10-dimethoxy-5,6,6aα,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
(6aS)-5,6,6a,7-Tetrahydro-1,10-dimethoxy-6-methyl-4H-dibenzo[de,g]quinoline-2,9-diol
4H-Dibenzo[de,g]quinoline-2,9-diol,5,6,6a,7-tetrahydro-1,10-diMethoxy-6-Methyl-, (6aS)-
Boldine CRS
ex Peumus boldus
(6aS)-1,10-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
(+)-boldine
(S)-1,10-Dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diol
*Tramadol Impurity 25
476-70-0
C19H21NO4
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