Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
- CAS No.
- 94695-50-8
- Chemical Name:
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
- Synonyms
- SKL919;Ethyl 2;Levofloxacin-17;Levofloxacin Impurity V;5-tetrafluorobenzoyl acetate;Ethyl(2,3,4,5-tetrafluorobenzo;ethy-2,3,4,5-tetrafluorobenzoylacetate;ETHYL 2,3,4,5-TETRAFLUOROBENZOYL ACETATE;Methyl (2,3,4,5-Tetrafluoro-Benzoyl)Acetate;Ethyl(2,3,4,5-Tetrafluorobenzoyl)acetate>
- CBNumber:
- CB2174431
- Molecular Formula:
- C11H8F4O3
- Molecular Weight:
- 264.17
- MDL Number:
- MFCD00523020
- MOL File:
- 94695-50-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Ethyl (2,3,4,5-Tetrafluorobenzoyl)acetate >98.0%(GC) | E0759 | 25g | $58 |
| Ethyl 2- | 448791 | 50mg | $305 |
| Ethyl 2- | 448786 | 100mg | $305 |
| Ethyl 2- | 448710 | 25mg | $305 |
| Ethyl 2- | 448700 | 100mg | $305 |
| More product size | |||
| Melting point | 41-44°C |
|---|---|
| Boiling point | 100 °C / 0.1mmHg |
| Density | 1.384 |
| Flash point | 123℃ |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| pka | 10.51±0.50(Predicted) |
| form | Solid |
| color | Off-White to Beige |
| InChI | InChI=1S/C11H8F4O3/c1-2-18-8(17)4-7(16)5-3-6(12)10(14)11(15)9(5)13/h3H,2,4H2,1H3 |
| InChIKey | KWDVJYLIAJHEOW-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)CC(C1=CC(F)=C(F)C(F)=C1F)=O |
| CAS DataBase Reference | 94695-50-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P264-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 |
| Hazard Codes | Xi |
| Safety Statements | 24/25 |
| Hazard Note | Irritant |
| HS Code | 29183000 |
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate price More Price(46)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E0759 | Ethyl (2,3,4,5-Tetrafluorobenzoyl)acetate >98.0%(GC) | 94695-50-8 | 25g | $58 | 2026-04-30 | Buy |
| Usbiological | 448791 | Ethyl 2- | 94695-50-8 | 50mg | $305 | 2021-12-16 | Buy |
| Usbiological | 448786 | Ethyl 2- | 94695-50-8 | 100mg | $305 | 2021-12-16 | Buy |
| Usbiological | 448710 | Ethyl 2- | 94695-50-8 | 25mg | $305 | 2021-12-16 | Buy |
| Usbiological | 448700 | Ethyl 2- | 94695-50-8 | 100mg | $305 | 2021-12-16 | Buy |
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Chemical Properties,Uses,Production
Chemical Properties
White or off-white crystal
Uses
2,3,4,5-Tetrafluorobenzoylacetic Acid Ethyl Ester is a fluorinated benzoylacetate used as a synthetic reagent in the preparation of antibacterial and potential antitumor agents.
Uses
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate is a fluorinated benzoylacetate used as a synthetic reagent in the preparation of antibacterial and potential antitumor agents.
Synthesis Reference(s)
Journal of Heterocyclic Chemistry, 24, p. 453, 1987 DOI: 10.1002/jhet.5570240228
Synthesis, p. 290, 1993 DOI: 10.1055/s-1993-25849
Synthesis
6148-64-7
94695-48-4
94695-50-8
General procedure for the synthesis of ethyl 3-oxo-3-(2,3,4,5-tetrafluorophenyl)propionate from monoethyl malonate potassium salt and tetrafluorobenzoyl chloride: monoethyl malonate potassium salt (3.66 g, 21.5 mmol), MgCl (2.44 g, 25.7 mmol) and triethylamine (TEA, 2.05 g, 20.3 mmol) were dissolved in acetonitrile (70 mL) in acetonitrile (70 mL) and the reaction was stirred for 2.5 h at 10-15 °C. Subsequently, a solution of 2,3,4,5-tetrafluorobenzoyl chloride (2.00 g, 10.3 mmol) in acetonitrile (10 mL) was slowly added dropwise at 0 °C for a controlled time of 15 min. After dropwise addition, TEA (0.23 g, 2.3 mmol) was added again. The reaction mixture was gradually warmed to room temperature and stirring was continued for 16 hours. After completion of the reaction, the volatiles were evaporated under reduced pressure. Toluene (30 mL) was added and evaporated again under reduced pressure. Subsequently, toluene (60 mL) was added and 1.5 M HCl (40 mL) was carefully added, controlling the reaction temperature to not exceed 25°C. The reaction was carried out under reduced pressure. The organic phase was washed sequentially with 1.5 M HCl (2 x 25 mL) and water (2 x 25 mL), dried with MgSO and finally concentrated under reduced pressure to give the target product ([M + 1] 265, 99% yield).
References
[1] Patent: WO2008/131134, 2008, A1. Location in patent: Page/Page column 57-58
[2] Synthesis, 1993, # 3, p. 290 - 292
[3] Patent: US2006/63761, 2006, A1. Location in patent: Page/Page column 5; 10-11
[4] Chemical Communications, 2013, vol. 49, # 46, p. 5313 - 5315
Ethyl 2,3,4,5-tetrafluorobenzoyl acetate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biviture Industrial Limited | +86-86-17786030126 +8615618508769 | luna@biviture.com | China | 84 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2994 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 967 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from Ethyl 2,3,4,5-tetrafluorobenzoyl acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-12-01 | Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
94695-50-8
|
US $0.00-0.00 / KG | 1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | |
 |
2025-06-27 | Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
94695-50-8
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2022-09-22 | Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
94695-50-8
|
US $0.00 / kg | 1kg | 99% | 1000kg | henan kanbei chemical co.,ltd |
-
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
94695-50-8
- US $0.00-0.00 / KG
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
94695-50-8
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Ethyl 2,3,4,5-tetrafluorobenzoyl acetate
94695-50-8
- US $0.00 / kg
- 99%
- henan kanbei chemical co.,ltd
