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4,6-Dichloro-2-methylpyrimidine

4,6-Dichloro-2-methylpyrimidine structure

CAS No.: 1780-26-3

Chemical Name:: 4,6-Dichloro-2-methylpyrimidine

Synonyms: 6-Dichloro-2-methylpyrimidine;2-METHYL-4,6-DICHLOROPYRIMIDINE;Pyrimidine, 4,6-dichloro-2-methyl-;2-MDCP;BUTTPARK 52\14-70;4,6-Dichloro-2-methy;Dasatinib Impurity 99;Dasatinib EP Impurity-B;4,6-Dicloro-2-methylpyrimidine;4,6-DICHLORO-2-METHYLPYRIMIDINE

CBNumber:: CB2176132

Molecular Formula:: C5H4Cl2N2

Molecular Weight:: 163

MDL Number:: MFCD00090472

MOL File:: 1780-26-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-20 15:44:49

Product description	Number	Pack Size	Price
4,6-Dichloro-2-methylpyrimidine 98%	596728	5g	$28.5
4,6-Dichloro-2-methylpyrimidine 98%	596728	25g	$105
4,6-Dichloro-2-methylpyrimidine >98.0%(GC)	D3558	5g	$27
4,6-Dichloro-2-methylpyrimidine >98.0%(GC)	D3558	25g	$107
2-METHYL-4,6-DICHLOROPYRIMIDINE 97%	27280	25G	$19
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4,6-Dichloro-2-methylpyrimidine Properties

Melting point	41.5-45.5 °C (lit.)
Boiling point	210.8±20.0 °C(Predicted)
Density	1.404±0.06 g/cm3(Predicted)
Flash point	208 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
pka	-3.84±0.30(Predicted)
form	Crystalline Powder or Crystals
color	White to off-white
InChI	InChI=1S/C5H4Cl2N2/c1-3-8-4(6)2-5(7)9-3/h2H,1H3
InChIKey	FIMUTBLUWQGTIJ-UHFFFAOYSA-N
SMILES	C1(C)=NC(Cl)=CC(Cl)=N1
CAS DataBase Reference	1780-26-3(CAS DataBase Reference)
FDA UNII	4UM8PK8RCC
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H302-H317-H411

Precautionary statements

P273-P280-P301+P312+P330-P302+P352

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

C,N,Xn

Risk Statements

34-51/53-43-22

Safety Statements

26-36/37/39-45-61-36/37

RIDADR

UN 3261 8/PG 2

WGK Germany

HazardClass

PackingGroup

III

HS Code

29335990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Chronic 2
Skin Sens. 1

NFPA 704

	1
3		0

4,6-Dichloro-2-methylpyrimidine price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	596728	4,6-Dichloro-2-methylpyrimidine 98%	1780-26-3	5g	$28.5	2026-04-30	Buy
Sigma-Aldrich	596728	4,6-Dichloro-2-methylpyrimidine 98%	1780-26-3	25g	$105	2026-04-30	Buy
TCI Chemical	D3558	4,6-Dichloro-2-methylpyrimidine >98.0%(GC)	1780-26-3	5g	$27	2026-04-30	Buy
TCI Chemical	D3558	4,6-Dichloro-2-methylpyrimidine >98.0%(GC)	1780-26-3	25g	$107	2026-04-30	Buy
AstaTech	27280	2-METHYL-4,6-DICHLOROPYRIMIDINE 97%	1780-26-3	25G	$19	2026-04-30	Buy

Product number	Packaging	Price	Buy
596728	5g	$28.5	Buy
596728	25g	$105	Buy
D3558	5g	$27	Buy
D3558	25g	$107	Buy
27280	25G	$19	Buy

4,6-Dichloro-2-methylpyrimidine Chemical Properties,Uses,Production

Chemical Properties

White to off-white solid

Uses

4,6-Dichloro-2-methylpyrimidine, is a versatile building block used for the synthesis of more complex pharmaceutical and biologically active compounds, such as Dasatinib (D290002), and its derivatives.

Application

The primary application of 4,6-dichloro-2-methylpyrimidine is as a key intermediate in the synthesis of the antihypertensive drug Moxonidine. Moxonidine is a centrally acting antihypertensive drug that exerts its antihypertensive effect by activating central α₂ receptors and imidazoline receptors. In its synthetic route, 4,6-dichloro-2-methylpyrimidine is used to construct the pyrimidine ring core structure, and key groups are introduced through substitution and other reactions to ultimately synthesize the target drug.

Synthesis

1194-22-5

1780-26-3

General procedure for the synthesis of 4,6-dichloro-2-methylpyrimidine from 6-hydroxy-2-methylpyrimidin-4-one: 4,6-dihydroxy-2-methylpyrimidine (5.0 g, 0.04 mol) was added to a mixed solution of thionyl chloride (18.9 g, 0.16 mol) with acetonitrile. The reaction mixture was stirred at 80 °C for 3 h and the completion of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, excess thionyl chloride was removed by distillation under reduced pressure and the residue was slowly poured into 50 g of ice water. The precipitated solid was filtered and purified by column chromatography to give 6.1 g (yield: 94%) of 4,6-dichloro-2-methylpyrimidine as a white solid.

References

[1] Tetrahedron Letters, 2009, vol. 50, # 41, p. 5729 - 5732
[2] Patent: CN106478519, 2017, A. Location in patent: Paragraph 0020-0023; 0030-0032; 0038-0040; 0049-0052
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 2969 - 2973
[4] Tetrahedron, 2006, vol. 62, # 10, p. 2304 - 2312
[5] Patent: WO2004/46133, 2004, A1. Location in patent: Page 40-41

4,6-Dichloro-2-methylpyrimidine synthesis

Synthesis of 4,6-Dichloro-2-methylpyrimidine from 4,6-Dihydroxy-2-methylpyrimidine

4,6-Dichloro-2-methylpyrimidine Preparation Products And Raw materials

Raw materials

4,6-Dihydroxy-2-methylpyrimidine Acetonitrile Thionyl chloride

Preparation Products

Moxonidine Dasatinib monohydrate 4-CHLORO-2,6-DIMETHYLPYRIMIDINE 4-Pyrimidinamine, 2-methyl- (9CI) 4-Amino-6-chloro-2-methylpyrimidine

Pyrimidine, 4-amino-2-methyl-6-(methylamino)- (6CI,8CI) 4,6-bis(3,5-dichlorophenyl)-2-methylpyrimidine 6-chloro-N,N,2-trimethyl-4-pyrimidinamine 4-(6-CHLORO-2-METHYLPYRIMIDIN-4-YL)MORPHOLINE 6-chloro-N-ethyl-2-MethylpyriMidin-4-aMine

2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide 4-chloro-6-(4-fluorophenyl)-2-methylpyrimidine Dasatinib

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4,6-Dichloro-2-methylpyrimidine Suppliers

Global( 580)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5233	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from 4,6-Dichloro-2-methylpyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	4,6-Dichloro-2-methylpyrimidine 1780-26-3	US $25.00 / ASSAYS	100ASSAYS	99.5%	100 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-01	4,6-Dichloro-2-methylpyrimidine 1780-26-3	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-11-18	4,6-Dichloro-2-methylpyrimidine 1780-26-3	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited

4,6-Dichloro-2-methylpyrimidine
1780-26-3
US $25.00 / ASSAYS
99.5%
Hebei Chuanghai Biotechnology Co., Ltd

4,6-Dichloro-2-methylpyrimidine
1780-26-3
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

4,6-Dichloro-2-methylpyrimidine
1780-26-3
US $1.10 / g
99.00%
Dideu Industries Group Limited

4,6-Dichloro-2-methylpyrimidine Spectrum

4,6-Dichloro-2-methylpyrimidine(1780-26-3)¹HNMR

1780-26-3(4,6-Dichloro-2-methylpyrimidine)Related Search:

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4,6-DICHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4,6-Dichloro-2-(methylthio)pyrimidine 4,7-Dichloro-6-nitroquinazoline Furo[2,3-d]pyridazine, 4,7-dichloro 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE

4,6-dichloro-2-propylthiopyrimidine-5-amine 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine 4,6-Dichloro-2-methyl-5-nitropyrimidine

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BUTTPARK 52\14-70 2-MDCP 2-METHYL-4,6-DICHLOROPYRIMIDINE 4,6-DICHLORO-2-METHYLPYRIMIDINE 4,6-Dichloro-2-methylpyrimidiine Pyrimidine, 4,6-dichloro-2-methyl- 4,6-Dichloro-2-methylpyrimidine ,99% 4,6-Dichloro-2-Methylpyrimidine/2,4-dichloro-6-methylpyrimidine 6-Dichloro-2-methylpyrimidine 4,6-Dichloro-2-methy 4,6-Dichloro-2-methylpyrimidine 98% 4,6-Dichloro-2-methylpyrimidine> 4,6-Dichloro-2-methylpyrimidine ISO 9001：2015 REACH 2-METHYL-4,6-DICHLORO?PYRMIDINE Dasatinib Impurity 99 4,6-Dicloro-2-methylpyrimidine Dasatinib EP Impurity-B 1780-26-3 C5H4N2Cl2 Pyrimidines Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Heterocycle-Pyrimidine series alkyl chloride Pyrimidines APIs & Intermediate Pyrimidine Halides Pyrazines, Pyrimidines & Pyridazines Pyrazines, Pyrimidines & Pyridazines Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks bc0001