Propham
- CAS No.
- 122-42-9
- Chemical Name:
- Propham
- Synonyms
- IPC;ISOPROPYL PHENYLCARBAMATE;y2;IFC;IFK;Y 2;INPC;IPPC;Tixit;Birgin
- CBNumber:
- CB2179522
- Molecular Formula:
- C10H13NO2
- Molecular Weight:
- 179.22
- MDL Number:
- MFCD00026382
- MOL File:
- 122-42-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Propham PESTANAL | 45641 | 50mg | $93.7 |
| Propham 97% | MT-58192 | 100g | $420 |
| Propham | P838888 | 250mg | $185 |
| Propham | P838888 | 500mg | $295 |
| IsopropylN-phenylcarbamate | J53177 | 25g | $177 |
| More product size | |||
| Melting point | 90°C |
|---|---|
| Boiling point | 311.75°C (rough estimate) |
| Density | 1.0900 |
| refractive index | 1.4989 (estimate) |
| Flash point | 11 °C |
| storage temp. | APPROX 4°C |
| pka | 13.74±0.70(Predicted) |
| form | Solid |
| color | Dark brown, blue-black |
| Water Solubility | 0.1g/L(25 ºC) |
| Merck | 13,7908 |
| BRN | 2209666 |
| Henry's Law Constant | 5.4×101 mol/(m3Pa) at 25℃, Duchowicz et al. (2020) |
| Major Application | agriculture |
| InChI | 1S/C10H13NO2/c1-8(2)13-10(12)11-9-6-4-3-5-7-9/h3-8H,1-2H3,(H,11,12) |
| InChIKey | VXPLXMJHHKHSOA-UHFFFAOYSA-N |
| SMILES | CC(C)OC(=O)Nc1ccccc1 |
| CAS DataBase Reference | 122-42-9(CAS DataBase Reference) |
| FDA UNII | Y647G714RY |
| IARC | 3 (Vol. 12, Sup 7) 1987 |
| NIST Chemistry Reference | Carbamic acid, phenyl-, 1-methylethyl ester(122-42-9) |
| EPA Substance Registry System | Propham (122-42-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| target organs | Eyes | |||||||||
| Hazard Codes | F,T,Xn | |||||||||
| Risk Statements | 36/37/38-39/23/24/25-23/24/25-11-22 | |||||||||
| Safety Statements | 26-36-45-16-7-36/37 | |||||||||
| RIDADR | UN 1230 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | FD9100000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29242990 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Flam. Liq. 2 STOT SE 1 |
|||||||||
| Hazardous Substances Data | 122-42-9(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in male, female rats (mg/kg): 3724, 4315 orally (Gaines, Linder) | |||||||||
| NFPA 704 |
|
Propham price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 45641 | Propham PESTANAL | 122-42-9 | 50mg | $93.7 | 2026-04-30 | Buy |
| AHH | MT-58192 | Propham 97% | 100g | $420 | 2026-05-26 | Buy | |
| TRC | P838888 | Propham | 122-42-9 | 250mg | $185 | 2021-12-16 | Buy |
| TRC | P838888 | Propham | 122-42-9 | 500mg | $295 | 2021-12-16 | Buy |
| AK Scientific | J53177 | IsopropylN-phenylcarbamate | 122-42-9 | 25g | $177 | 2021-12-16 | Buy |
Propham Chemical Properties,Uses,Production
Chemical Properties
White to gray crystalline needles; odorless when pure. Mp 84C (technical grade). Soluble in alcohol, acetone, isopropyl alcohol; insoluble in water.
Chemical Properties
Propham is a colorless crystalline solid.
Uses
Herbicide, applied as a spray to the soil.
Uses
Preemergence and postemergence herbicide used to control annual grass weeds in peas, beet crops, lucerne, clover, sugar beet, beans, lettuce, flax, safflowers and lentils.
Uses
Inhibitor of plant metabolism
Definition
ChEBI: Propham is a carbamate ester that is the isopropyl ester of phenylcarbamic acid. It is a selective herbicide used for the control of annual grasses and some broad-leaf weeds and is also a growth regulator for control of sprouting in stored potatoes. It has a role as a herbicide and a plant growth retardant. It is a carbamate ester and a member of benzenes.
Production Methods
The industrial synthesis of propham begins with the preparation of phenyl isocyanate, which is typically derived from aniline via phosgenation. This intermediate is then reacted with isopropyl alcohol under controlled conditions to form the carbamate ester. The reaction is carried out in organic solvents such as toluene or acetone, with temperature and pH carefully regulated to ensure high yield and purity. The resulting product is purified through distillation or crystallisation.
General Description
Colorless crystalline solid.
Reactivity Profile
Propham is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
Hazard
Toxic by ingestion.
Health Hazard
Moderately toxic herbicide; exhibited low tomoderate toxicity in experimental animalswhen administered by oral, intraperitoneal,intravenous, and subcutaneous routes; skinabsorption is slow; cholinesterase inhibitor;in human ingestion can cause carbamatepoisoning, which can be lethal when takenin large amount; probable lethal oral dosein adult human estimated to be larger thanother carbamate insecticides within the range35–50 g.
Mechanism of action
Selective, systemic, mitosis inhibitor
Safety Profile
Poison by intraperitoneal route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion and possibly other routes. An experimental teratogen. Human mutation data reported. Questionable carcinogen with experimental neoplastigenic data. An herbicide. When heated to decomposition it emits toxic fumes of NO,. See also CARBAMATES.
Potential Exposure
A potential danger to those involved in the manufacture, formulation and application of this car- bamate/organonitrogen grass-control herbicide.
Environmental Fate
Biological. Rajagopal et al. (1989) reported that Achromobacter sp. and an Arthrobacter sp. utilized propham as a sole carbon source. Metabolites identified were Nphenylcarbamic acid, aniline, catechol, monoisopropyl carbonate, 2-propanol and carbon
dioxide (Rajagopal et al., 1989).
Soil. Readily degraded by soil microorganisms forming aniline and carbon dioxide
(Humburg et al., 1989). The reported half-life in soil is approximately 15 and 5 days at
16 and 29°C, respectively (Hartley and Kidd, 1987).
Groundwater. According to the U.S. EPA (1986) propham has a high potential to leach
to groundwater.
Plant. The major plant metabolite which was identified from soybean plants is isopropyl N-2-hydroxycarbanilate (Hartley and Kidd, 1987; Humburg et al., 1989).
Chemical/Physical. Hydrolysis of propham yields N-phenylcarbamic acid and 2-propanol. The acid is very unstable and is spontaneously decomposed to form aniline and
carbon dioxide (Still and Herrett, 1976). Emits toxic fumes of nitrogen oxides when heated
to decomposition (Sax and Lewis, 1987).
Shipping
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz- ardous material, Technical Name Required. UN2757 Carbamate pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
Carbamates are incompatible with reduc- ing agents, strong acids, oxidizing acids, peroxides, and bases. Contact with active metals or nitrides cause the release of flammable, and potentially explosive, hydrogen gas. May react violently with bromine, ketones. Incompatible with azo dyes, caustics, ammonia, amines, boranes, hydrazines, strong
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recom- mendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following pack- age label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
Pesticide Type
Herbicide; Plant Growth Regulator
Propham Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1298 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49860 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
