5-Thiazolecarboxaldehyde, 2-cyclopropyl-
- CAS No.
- 877385-86-9
- Chemical Name:
- 5-Thiazolecarboxaldehyde, 2-cyclopropyl-
- Synonyms
- 2-Cyclopropyl-5-formyl-1,3-thiazole;2-cyclopropylthiazole-5-carbaldehyde;2-cyclopropylthiazole-5-methylaldehyde;2-cyclopropyl-5-Thiazolecarboxaldehyde;5-Thiazolecarboxaldehyde, 2-cyclopropyl-;2-Cyclopropyl-1,3-thiazole-5-carboxaldehyde
- CBNumber:
- CB21863530
- Molecular Formula:
- C7H7NOS
- Molecular Weight:
- 153.2
- MDL Number:
- MFCD14615179
- MOL File:
- 877385-86-9.mol
- MSDS File:
- SDS
| Boiling point | 278.5±13.0 °C(Predicted) |
|---|---|
| Density | 1.370±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 1.66±0.10(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C7H7NOS/c9-4-6-3-8-7(10-6)5-1-2-5/h3-5H,1-2H2 |
| InChIKey | ORNIFVGIJQCIMW-UHFFFAOYSA-N |
| SMILES | S1C(C=O)=CN=C1C1CC1 |
5-Thiazolecarboxaldehyde, 2-cyclopropyl- price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR40534 | 2-Cyclopropyl-1,3-thiazole-5-carboxaldehyde 95% | 877385-86-9 | 100mg | $56 | 2026-06-04 | Buy |
| Apolloscientific | OR40534 | 2-Cyclopropyl-1,3-thiazole-5-carboxaldehyde 95% | 877385-86-9 | 250mg | $69 | 2026-06-04 | Buy |
| Apolloscientific | OR40534 | 2-Cyclopropyl-1,3-thiazole-5-carboxaldehyde 95% | 877385-86-9 | 1g | $270 | 2026-06-04 | Buy |
| Apolloscientific | OR40534 | 2-Cyclopropyl-1,3-thiazole-5-carboxaldehyde 95% | 877385-86-9 | 5g | $1127 | 2026-06-04 | Buy |
| Matrix Scientific | 303700 | 2-Cyclopropylthiazole-5-carbaldehyde | 877385-86-9 | 250.00mg | $67 | 2026-05-19 | Buy |
5-Thiazolecarboxaldehyde, 2-cyclopropyl- Chemical Properties, Uses, Production
Synthesis
1159821-56-3
68-12-2
877385-86-9
Compound 10b (1.8 g, 14.4 mmol) was dissolved in tetrahydrofuran (30 mL) under nitrogen protection and cooled to -78 °C. 2.5 M n-butyllithium (n-BuLi) solution (6.3 mL, 15.8 mmol) was slowly added dropwise and the reaction mixture was stirred at this temperature for 1 hour. Subsequently, N,N-dimethylformamide (DMF) (1.6 g, 21.6 mmol) was added and the mixture was gradually warmed to room temperature and stirring was continued for 3 hours. After completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl) solution and extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the crude product was purified by silica gel (SiO2) column chromatography with the eluent being a solvent mixture of petroleum ether and ethyl acetate (the ratio was varied from 50:1 to 20:1 gradient) to give the target compound 10c (1.5 g, 49% yield).
References
[1] Patent: WO2014/110705, 2014, A1. Location in patent: Page/Page column 70
[2] Patent: WO2014/110687, 2014, A1. Location in patent: Page/Page column 51
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 290 - 306
5-Thiazolecarboxaldehyde, 2-cyclopropyl- Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
5-Thiazolecarboxaldehyde, 2-cyclopropyl- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
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| Moltt Biocem Co., Ltd. | +86-21-38682181 15900741819 | China | 281 | 55 | |
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View Latest Price from 5-Thiazolecarboxaldehyde, 2-cyclopropyl- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-04 | 2-Cyclopropylthiazole-5-carbaldehyde
877385-86-9
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
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 |
2020-02-19 | 5-Thiazolecarboxaldehyde, 2-cyclopropyl-
877385-86-9
|
$7.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 2-Cyclopropylthiazole-5-carbaldehyde
877385-86-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 5-Thiazolecarboxaldehyde, 2-cyclopropyl-
877385-86-9
- $7.00
- 99%
- Career Henan Chemical Co
