3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
- CAS No.
- 639068-43-2
- Chemical Name:
- 3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester
- Synonyms
- Methisosildenafil-002;Methisosildenafil impure4;Methisosildenafil Impurity;Methisosildenafil Impurity 29;tert-Butyl 3,5-diMethylpiperazine-1-carboxylate;tert-Butyl 3,5-dimethyl-1-piperazinecarboxylate;1,1-Dimethylethyl 3,5-dimethyl-1-piperazinecarboxylate;2-Methyl-2-propanyl 3,5-dimethyl-1-piperazinecarboxylate;3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 3,5-diMethyl-, 1,1-diMethylethyl ester
- CBNumber:
- CB21874141
- Molecular Formula:
- C11H22N2O2
- Molecular Weight:
- 214.3
- MDL Number:
- MFCD07371499
- MOL File:
- 639068-43-2.mol
| Product description | Number | Pack Size | Price |
| tert-Butyl 3,5-Dimethylpiperazine-1-carboxylate (cis- and trans- mixture) min. 98.0 % | D6456 | 200MG | $60 |
| tert-Butyl 3,5-Dimethylpiperazine-1-carboxylate (cis- and trans- mixture) min. 98.0 % | D6456 | 1G | $150 |
| 1-Boc-3,5-dimethylpiperazine | B201880 | 500mg | $110 |
| 1-Boc-3,5-Dimethylpiperazine | Z4986 | 1g | $144 |
| tert-Butyl 3,5-dimethylpiperazine-1-carboxylate | FB143070 | 1g | $101 |
| Boiling point | 279.7±15.0 °C(Predicted) |
|---|---|
| Density | 0.970±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 8.58±0.60(Predicted) |
| Appearance | Off-white to light yellow Solid |
| CAS DataBase Reference | 639068-43-2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | D6456 | tert-Butyl 3,5-Dimethylpiperazine-1-carboxylate (cis- and trans- mixture) min. 98.0 % | 639068-43-2 | 200MG | $60 | 2025-07-31 | Buy |
| TCI Chemical | D6456 | tert-Butyl 3,5-Dimethylpiperazine-1-carboxylate (cis- and trans- mixture) min. 98.0 % | 639068-43-2 | 1G | $150 | 2025-07-31 | Buy |
| TRC | B201880 | 1-Boc-3,5-dimethylpiperazine | 639068-43-2 | 500mg | $110 | 2021-12-16 | Buy |
| AK Scientific | Z4986 | 1-Boc-3,5-Dimethylpiperazine | 639068-43-2 | 1g | $144 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB143070 | tert-Butyl 3,5-dimethylpiperazine-1-carboxylate | 639068-43-2 | 1g | $101 | 2021-12-16 | Buy |
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production
Synthesis
24424-99-5
108-49-6
639068-43-2
General procedure for the synthesis of 1-Boc-3,5-dimethylpiperazine from di-tert-butyl dicarbonate and 2,6-dimethylpiperazine: 2,6-dimethylpiperazine (200.0 mg, 1.75 mmol) and triethylamine (TEA, 0.6 mL, 4.37 mmol) were dissolved in dichloromethane (DCM, 6.0 mL), and di-tert-butyl dicarbonate (DTBD, 1.5 mmol, 2.6 mL) was added slowly at 0 °C. butyl dicarbonate ((Boc)2O, 458.7 mg, 2.10 mmol) was added slowly at 0 °C. The reaction mixture was stirred at room temperature for 12 hours and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent ratio: DCM:MeOH = 95:5). The fraction containing the target product was collected and evaporated to give tert-butyl 3,5-dimethylpiperazine-1-carboxylate (210.0 mg, 56% yield) as a yellow liquid.1H-NMR (300 MHz, CDCl3) δ: 3.95 (m, 2H), 2.79 (m, 2H), 2.33 (m, 2H), 1.46 (s, 9H), 1.07 (d. 6H, J = 6.3 Hz).
References
[1] Patent: US2005/54850, 2005, A1
[2] Patent: US2014/315888, 2014, A1. Location in patent: Paragraph 0558-0559
[3] Patent: US6235731, 2001, B1
[4] Patent: EP2154135, 2010, A1. Location in patent: Page/Page column 16
[5] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 27-28
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Dimethyl-piperazine-1-carboxylic acid tert-butyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39002 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2999 | 61 |
| Nanjing Habo Medical Technology Co., Ltd. | 025-85760892 13376080562 | sales@habotech.com | China | 882 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 | info@chemlin.com.cn | China | 14830 | 64 |
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