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N-(p-Aminobenzoyl)glutamic acid

N-(p-Aminobenzoyl)glutamic acid structure

CAS No.: 4271-30-1

Chemical Name:: N-(p-Aminobenzoyl)glutamic acid

Synonyms: N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID;Methotrexate EP Impurity K;(2S)-2-(4-Aminobenzamido)pentanedioic Acid;(2S)-2-[(4-Aminobenzoyl)amino]pentanedioic Acid;NSC 71042;H-4-ABZ-GLU-OH;Folic acid iMpurity A;Methotrexate Impurity K;Folic Acid EP Impurity A;P-aminobenzoyl glutamate

CBNumber:: CB2193546

Molecular Formula:: C12H14N2O5

Molecular Weight:: 266.25

MDL Number:: MFCD00042821

MOL File:: 4271-30-1.mol

Last updated:2026-01-13 11:16:33

Product description	Number	Pack Size	Price
Folic acid impurity A European Pharmacopoeia (EP) Reference Standard	Y0001242	25 mg	$225
N-(4-Aminobenzoyl)-L-glutamic acid ≥98% (TLC)	A0879	5g	$502
N-(4-Aminobenzoyl)-L-glutamic acid United States Pharmacopeia (USP) Reference Standard	1019870	50mg	$392
N-(4-Aminobenzoyl)-L-glutamic Acid >97.0%(T)	A0442	1g	$97
N-(4-Aminobenzoyl)-L-glutamic Acid >97.0%(T)	A0442	5g	$315
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N-(p-Aminobenzoyl)glutamic acid Properties

Melting point	~175 °C (dec.)
alpha	-15 º (c=2% in 0.1N HCl)
Boiling point	409.45°C (rough estimate)
Density	1.2846 (rough estimate)
refractive index	1.6660 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility	Aqueous Base (Sparingly), Aqueous Acid (Sparingly), DMSO (Sparingly)
form	Solid
pka	3.50±0.10(Predicted)
color	White to Light
Merck	14,426
BRN	2816320
Stability	Hygroscopic
Major Application	detection peptide synthesis
InChI	1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/t9-/m0/s1
InChIKey	GADGMZDHLQLZRI-VIFPVBQESA-N
SMILES	Nc1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O
CAS DataBase Reference	4271-30-1(CAS DataBase Reference)
FDA UNII	9BKY99A8HJ
UNSPSC Code	41116107
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P271-P280
PPE	Eyeshields, Gloves, type N95 (US)
Risk Statements	36/37/38
Safety Statements	26-36/37/39
WGK Germany	3
HS Code	2924296000
Storage Class	11 - Combustible Solids

N-(p-Aminobenzoyl)glutamic acid price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	Y0001242	Folic acid impurity A European Pharmacopoeia (EP) Reference Standard	4271-30-1	25 mg	$225	2025-07-31	Buy
Sigma-Aldrich	A0879	N-(4-Aminobenzoyl)-L-glutamic acid ≥98% (TLC)	4271-30-1	5g	$502	2025-07-31	Buy
Sigma-Aldrich	1019870	N-(4-Aminobenzoyl)-L-glutamic acid United States Pharmacopeia (USP) Reference Standard	4271-30-1	50mg	$392	2025-07-31	Buy
TCI Chemical	A0442	N-(4-Aminobenzoyl)-L-glutamic Acid >97.0%(T)	4271-30-1	1g	$97	2025-07-31	Buy
TCI Chemical	A0442	N-(4-Aminobenzoyl)-L-glutamic Acid >97.0%(T)	4271-30-1	5g	$315	2025-07-31	Buy

Product number	Packaging	Price	Buy
Y0001242	25 mg	$225	Buy
A0879	5g	$502	Buy
1019870	50mg	$392	Buy
A0442	1g	$97	Buy
A0442	5g	$315	Buy

N-(p-Aminobenzoyl)glutamic acid Chemical Properties,Uses,Production

Chemical Properties

Light Tan Waxy Solid

Uses

Marker in folate metabolism studies.

Uses

Major metabolite of 5-Methyltetrahydrofolic Acid

Definition

ChEBI: A dipeptide resulting from the formal condensation of the carboxylic acid group of 4-aminobenzoic acid with the amino group of L-glutamic acid.

Biological Activity

N-p-Aminobenzoyl)-L-glutamic acid is a folate catabolite th at can be metabolized by bacterial p-aminobenzoate auxotrophs possessing the enzyme p-aminobenzoyl-glutamate hydrolase.

Synthesis

6758-40-3

4271-30-1

General procedure for the synthesis of N-(4-aminobenzoyl)-L-glutamic acid from N-p-nitrobenzoylglutamic acid: 27.23 g (0.1 mol) of N-nitrobenzoyl-L-glutamic acid and 118 g of methanol were added to a reaction vessel, and stirred until complete dissolution. Subsequently, 0.59 g of 10% Pd/C catalyst was added and 18.92 g (0.3 mol) of ammonium formate was added slowly. The reaction mixture was stirred at room temperature and kept for 30 minutes. After completion of the reaction, the Pd/C catalyst was recovered by filtration. The filtrate was adjusted to pH=3 with hydrochloric acid in methanol and left to stand for 30 min before filtering the precipitated crystals. The crystals were washed with a small amount of methanol and dried to give 25.75 g of N-(4-aminobenzoyl)-L-glutamic acid, with 99.88% purity by HPLC, 96.58% yield, and 95.64% total yield as nitrobenzoic acid.

Purification Methods

Crystallise the acid from H2O. Also purify it by dissolving 2.7g in H2O (130mL), adding aqueous NaOH to pH 5.5 and adding portionwise a solution of 0.5M CuSO4 to complete precipitation of the Cu salt. This salt is filtered off, suspended in H2O and H2S is bubbled through to precipitate CuS, filter, evaporate and recrystallise the residue from H2O. It has max (H2O) at 273nm. [Backer & Houtman Recl Trav Chim Pays-Bas 70 738, 743 1951, Beilstein 14 IV 1153.]

References

[1] Patent: CN105439895, 2016, A. Location in patent: Paragraph 0029; 0030
[2] Chirality, 2010, vol. 22, # 2, p. 252 - 257
[3] Journal of the Chemical Society, 1949, p. 1401,1404
[4] Yakugaku Zasshi, 1949, vol. 69, p. 457
[5] Chem.Abstr., 1950, p. 3442

N-(p-Aminobenzoyl)glutamic acid synthesis

Synthesis of N-(p-Aminobenzoyl)glutamic acid from P-NITROBENZOYL-L-GLUTAMIC ACID

N-(p-Aminobenzoyl)glutamic acid Preparation Products And Raw materials

Raw materials

4-Nitrobenzoyl chloride P-NITROBENZOYL-L-GLUTAMIC ACID Purple 4-Nitrobenzoic acid Ammonium sulfide

Activated carbon Ammonium formate Methanol Palladium

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Preparation Products

Aminopterin Folic acid

N-(p-Aminobenzoyl)glutamic acid Suppliers

Global( 491)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TAIZHOU DKD CHEMICAL CO., LTD.	+8618658336633	yf.chen@tzdkdchem.com	China	134	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
airuikechemical co., ltd.	+86-18353166132	sales02@airuikechemical.com	China	983	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Dalian Richfortune Chemicals Co., Ltd	+86-86-411-84820922 +86-8613904096939	sales@richfortunechem.com	China	305	57
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58

Supplier	Advantage
TAIZHOU DKD CHEMICAL CO., LTD.	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Changzhou Rokechem Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co., Ltd	58
airuikechemical co., ltd.	58
Capot Chemical Co.,Ltd.	60
Dalian Richfortune Chemicals Co., Ltd	57
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58

View Lastest Price from N-(p-Aminobenzoyl)glutamic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-06	N-(4-Aminobenzoyl)-L-glutamic acid 4271-30-1	US $0.00 / kg	1kg	98.5%	200mt/year	Jinan Finer Chemical Co., Ltd
2026-02-03	N-(p-Aminobenzoyl)glutamic acid 4271-30-1	US $0.00-0.00 / Kg/Drum	1KG	98%min	1000KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2025-12-01	N-(p-Aminobenzoyl)glutamic acid 4271-30-1	US $0.00 / kg	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

N-(4-Aminobenzoyl)-L-glutamic acid
4271-30-1
US $0.00 / kg
98.5%
Jinan Finer Chemical Co., Ltd

N-(p-Aminobenzoyl)glutamic acid
4271-30-1
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

N-(p-Aminobenzoyl)glutamic acid
4271-30-1
US $0.00 / kg
99%
Shaanxi Dideu New Materials Co. Ltd

N-(p-Aminobenzoyl)glutamic acid Spectrum

N-(p-Aminobenzoyl)glutamic acid(4271-30-1)¹HNMR N-(p-Aminobenzoyl)glutamic acid(4271-30-1)IR1

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H-4-ABZ-GLU-OH N-(P-AMINOBENZOYL)-L-GLUTAMIC ACID P-AMINOBENZOYL-L-GLUTAMIC ACID P-AMINO BENZAMIDE GLUTAMIC ACID N-(4-AMINOBENZOYL)-L-GLUTAMIC ACID N-(4-Aminobenzoyl)-L-Glutaminic Acid L-Glutamic acid, N-(4-aminobenzoyl)- N-(p-Aminobenzoyl)glutamic acid 2-[(4-aminobenzoyl)amino]glutaric acid 2-[(4-azanylphenyl)carbonylamino]pentanedioic acid 4-AMINOBENZOYLGLUTAMIC ACID 4-AMINOBENZOIC GLUTAMIC ACID 4-aminobenzoyl－L-glutamic acid NSC 71042 (S)-2-(4-AMinobenzaMido)pentanedioic acid Folic acid iMpurity A Folic acid iMpurity A N-(4-AMinobenzoyl)-L-glutaMic acid N-(P-Aminobenzoyl)-L-glutamic acidN-(P-Aminobenzoyl)-L-(+)glutamicacid EuE N-(4-aminobenzoyl)-L-Glutamic acid (Folic Acid Imp A) 4-Aminobenzoylglutamic Acid (50 mg) Methotrexate Impurity K Methotrexate EP Impurity K Methotrexate Impurity 11(EP-K) (2S)-2-[(4-aminophenyl)formamido]pentanedioic acid Methotrexate Impurity K (Folinic Acid Impurity A) Calcium Levofolinate EP Impurity A Calcium Levofolinate Impurity 1(Calcium Levofolinate EP Impurity A) N-(4-carbamoyl)-L-glutamic acid Folinic Acid Impurity A (Methotrexate Impurity K) N-(4-Aminobenzoyl)-L-glutamic Acid > (2S)-2-[(4-Aminobenzoyl)amino]penta Folic acid impurity A CRS N-4-Aminobenzoyl-L-glutaminsure Folinic Acid Impurity A (4-Aminobenzoyl Glutamic Acid) Impurity A of Calcium Levofolinate Levofolinate EP Impurity A Folic Acid EP Impurity A Folic Acid Impurity 1（Folic Acid EP Impurity A） N-(4-aminobenzoyl)-L-glutamicaci Methotrexate Impurity 11（Methotrexate EP Impurity K） N-(p-Aminobenzoyl)glutamic acid USP/EP/BP N-p-aminobenzoyl-L-glutamic acid USP/EP/BP Para amino-benzoyl glutamate Folic Acid EP Impurity A (Methotrexate EP Impurity K) Methotrexate EP Impurity K (Folic Acid EP Impurity A) N-(4-Aminobenzoyl)-L-glutamic acid, ≥98% (TLC) Folic acid Impurity AQ: What is Folic acid Impurity A Q: What is the CAS Number of Folic acid Impurity A Q: What is the storage condition of Folic acid Impurity A 4-Aminobenzoylglutamic Acid (F0M031) (2S)-2-(4-Aminobenzamido)pentanedioic Acid (2S)-2-[(4-Aminobenzoyl)amino]pentanedioic Acid 4-Aminobenzoylglutamic Acid (1019870) Methotrexate EP Impurity K (Folinic Acid EP Impurity A) N-(4-aminobenzoyl) -L-glutamate (2S)-2-[(4-Aminobenzoyl)amino]pentanedioic Acid (N-(4-Aminobenzoyl)-L-glutamic Acid) Calcium Folinate EP Impurity A Folic Acid Hydrate EP Impurity A N-(p-Aminobenzoyl)glutamicaci Folinic Acid Impurity A (Methotrexate EP Impurity K)