Cinobufagin
- CAS No.
- 470-37-1
- Chemical Name:
- Cinobufagin
- Synonyms
- 3-PHENYLACRYLIC ACID;FEMA 2288;AKOS 233-01;CINOBUFAGIN;16-beta)-bet;cinobufagine;AKOS B004228;CINOBUFAGIN(P);Cinobufagin-RM;Cinobufagin std.
- CBNumber:
- CB2206701
- Molecular Formula:
- C26H34O6
- Molecular Weight:
- 442.55
- MDL Number:
- MFCD00056825
- MOL File:
- 470-37-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 133 °C(lit.) |
|---|---|
| Boiling point | 300 °C(lit.) |
| Density | 1.261 g/cm3 |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml |
| pka | 15.10±0.70(Predicted) |
| form | powder to crystal |
| color | White to Light yellow |
| InChIKey | SCULJPGYOQQXTK-QZXYOKJUNA-N |
| SMILES | C[C@]12CC[C@]3([H])[C@]4(CC[C@H](O)C[C@@]4([H])CC[C@@]3([H])[C@@]31O[C@@H]3[C@H](OC(=O)C)[C@@H]2C1=COC(=O)C=C1)C |&1:1,4,6,9,12,16,18,20,21,26,r| |
| FDA UNII | T9PSN4R8IR |
| NCI Drug Dictionary | cinobufagin |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H310-H330 | |||||||||
| Precautionary statements | P260-P264-P280-P284-P302+P350-P310 | |||||||||
| Hazard Codes | Xi,T+,Xn | |||||||||
| Risk Statements | 36/37/38-26/27/28-42/43-20/22 | |||||||||
| Safety Statements | 26-36-45-36/37/39-22-24/25 | |||||||||
| RIDADR | UN 2811 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GD7850000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29322090 | |||||||||
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
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| Hazard Classifications | Acute Tox. 1 Inhalation Acute Tox. 2 Dermal Acute Tox. 2 Oral |
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| NFPA 704 |
|
Cinobufagin price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3135 | Cinobufagin ≥98% (HPLC) | 470-37-1 | 5 mg | $111 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3135 | Cinobufagin ≥98% (HPLC) | 470-37-1 | 25 mg | $442 | 2026-04-30 | Buy |
| TCI Chemical | C3460 | Cinobufagine >98.0%(HPLC) | 470-37-1 | 25mg | $200 | 2026-04-30 | Buy |
| TCI Chemical | C3460 | Cinobufagine >98.0%(HPLC) | 470-37-1 | 100mg | $576 | 2026-04-30 | Buy |
| Cayman Chemical | 19844 | Cinobufagin ≥98% | 470-37-1 | 5mg | $127 | 2026-04-30 | Buy |
Cinobufagin Chemical Properties,Uses,Production
Description
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.
References
1. https://en.wikipedia.org/wiki/Cinobufagin
2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412
3. http://www.yourdictionary.com/cinobufagin
4. https://www.medchemexpress.com/cinobufagin.html
Description
Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na+/K+-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC50 values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.
Chemical Properties
Soluble in chloroform, methanol and other organic solvents, insoluble in water. Derived from the dried secretion of toads such as Bufo bufo gargarizans Cantor.
Uses
Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.
Definition
ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.
in vivo
Cinobufagin (5 mg/kg for i.p., once a day for 10 days) inhibits xenograft growth by inducing cell apoptosis in tumor xenograft mice model[1].
Cinobufagin (5 mg/kg for i.p., once a day for 10 days) suppresses tumor growth in both subcutaneous and intracranial U87MG-EGFR xenograft mouse models and increases the median survival of nude mice bearing intracranial U87MGEGFR tumors[2].
| Animal Model: | OCM1 cells tumor xenograft in Nu/Nu nude mice [1] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), once a day for 10 days |
| Result: | Made the tumors grew more slowly than those treated with intraperitoneal injection of saline or untreated. Increased the expression of caspase-3 and PARP in tumor tissues and decreased Bcl-2 and Bcl-xl expression in mouse tumor tissues and increased expression of Bad and Bax. |
| Animal Model: | U87MG-EGFR subcutaneous and intracranial xenograft model[2] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), once a day for 10 days |
| Result: | Decreased the luminescence intensity of brain tumor about 70%. Decreased p-EGFR, p-STAT3, and p-Akt levels in the intracranial tumors as compared with the vehicles. Decreased Ki67 and active caspase-3 immunostaining of intracranial tumors. |
References
[1] S TOMA. Metabolism and pharmacokinetics of cinobufagin.[J]. Xenobiotica, 1987, 17 10: 1195-1202. DOI: 10.3109/00498258709167411
[2] XING-SHENG LU. Preclinical study of cinobufagin as a promising anti-colorectal cancer agent[J]. Oncotarget, 2016, 8 1: 988-998. DOI: 10.18632/oncotarget.13519
[3] SHANSHAN XIE. Cinobufagin Modulates Human Innate Immune Responses and Triggers Antibacterial Activity.[J]. ACS Applied Bio Materials, 2016: e0160734. DOI: 10.1371/journal.pone.0160734
[4] LONGSHENG XU. Alpha-7 Nicotinic Receptor-Targeted Cinobufagin Induces Antinociception and Inhibits NF-κB Signaling Pathway in DRG Neurons[J]. ACS Chemical Neuroscience, 2018, 10 1: 497-506. DOI: 10.1021/acschemneuro.8b00369
Cinobufagin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Endesa Bio-tech Co., Ltd. | 025-58862853 18915922038 | sales@endesachem.com | China | 590 | 58 |
| Shanghai Fuorain BioTech Co., Ltd | 18672534757 | xiaoxue.hu@fuorain.cn | China | 2039 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Aktin Chemicals, Inc. | 86-28-85159085 | info@aktinchem.com | China | 297 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
View Lastest Price from Cinobufagin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Cinobufagin
470-37-1
|
$44.00-147.00 | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-08-07 | Cinobufagin
470-37-1
|
$1.00-100.00 | 1KG | 95% | 300KG | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-02-24 | Cinobufagin
470-37-1
|
5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Cinobufagin
470-37-1
- $44.00-147.00
- 99.89%
- TargetMol Chemicals Inc.
-
- Cinobufagin
470-37-1
- $1.00-100.00
- 95%
- Shaanxi Dideu Medichem Co. Ltd
-
- Cinobufagin
470-37-1
- $0.00
- Analytical Standard
- Shanghai Standard Technology Co., Ltd.
