3-Bromo-5-methoxy benzonitrile
- CAS No.
- 867366-91-4
- Chemical Name:
- 3-Bromo-5-methoxy benzonitrile
- Synonyms
- 3-Bromo-5-cyanoanisole;3-BROMO-5-METHOXYBENZOTRILE;3-Bromo-5-methoxy benzonitrile;Benzonitrile, 3-bromo-5-methoxy-;3-Bromo-5-methoxybenzonitrile 99%;3-BROMO-5-METHOXYBENZONITRILE,98%;3-Bromo-5-cyanoanisole, 5-Bromo-m-anisonitrile
- CBNumber:
- CB2226606
- Molecular Formula:
- C8H6BrNO
- Molecular Weight:
- 212.04
- MDL Number:
- MFCD08061971
- MOL File:
- 867366-91-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P280 |
| RIDADR | UN3439 |
| HazardClass | 6.1 |
| HS Code | 2926907090 |
| Limited Quantities | 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
3-Bromo-5-methoxy benzonitrile price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS32494 | 3-Bromo-5-methoxybenzonitrile 98% | 867366-91-4 | 1g | $22 | 2026-06-04 | Buy |
| Activate Scientific | AS32494 | 3-Bromo-5-methoxybenzonitrile 98% | 867366-91-4 | 5g | $49 | 2026-06-04 | Buy |
| Activate Scientific | AS32494 | 3-Bromo-5-methoxybenzonitrile 98% | 867366-91-4 | 25g | $161 | 2026-06-04 | Buy |
| Activate Scientific | AS32494 | 3-Bromo-5-methoxybenzonitrile 98% | 867366-91-4 | 100g | $534 | 2026-06-04 | Buy |
| Apolloscientific | OR17817 | 3-Bromo-5-methoxybenzonitrile 95% | 867366-91-4 | 1g | $21 | 2026-06-04 | Buy |
3-Bromo-5-methoxy benzonitrile Chemical Properties, Uses, Production
Synthesis
867366-90-3
867366-91-4
The general procedure for the synthesis of 3-bromo-5-methoxybenzonitrile from the compound (CAS:867366-90-3) is as follows: a mixed solution of aldehyde 180b (12.0 g, 56 mmol), hydroxylamine hydrochloride (19.4 g, 5 eq.), ethanol (100 mL), and pyridine (10 mL) was heated to 65 °C and reacted for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted by partitioning with 50% ethyl acetate/hexane and water. The organic layer was washed with brine and dried with magnesium sulfate. After evaporation of the volatiles, 12.4 g of the oxime product was obtained (97% yield). The resulting oxime was dissolved in anhydrous dioxane (100 mL) and pyridine (26 mL, 6 eq.), the solution was cooled to 0 °C and trifluoroacetic anhydride (15 mL, 2 eq.) was added slowly. Subsequently, the mixture was gradually warmed to room temperature and stirred continuously for 2 days. After that, the reaction solution was heated to 60 °C and kept for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water. The mixture was extracted with dichloromethane and the combined organic layers were washed sequentially with water, 1 M hydrochloric acid and brine. The organic layer was dried over magnesium sulfate and the solvent was evaporated to give the target product 180c 10.4 g (90% yield).
References
[1] Patent: US2005/239881, 2005, A1. Location in patent: Page/Page column 47-48
[2] Patent: US2008/20981, 2008, A1. Location in patent: Page/Page column 19
[3] Patent: US2008/45511, 2008, A1. Location in patent: Page/Page column 21
[4] Patent: US2008/293664, 2008, A1. Location in patent: Page/Page column 16
[5] Patent: US2008/249151, 2008, A1. Location in patent: Page/Page column 21
3-Bromo-5-methoxy benzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3827 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2853 | 52 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 |
View Latest Price from 3-Bromo-5-methoxy benzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | 3-BROMO-5-METHOXY BENZONITRILE
867366-91-4
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3-BROMO-5-METHOXY BENZONITRILE
867366-91-4
- $1.00
- 99%
- Career Henan Chemical Co
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