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tert-Butyllithium

tert-Butyllithium structure

CAS No.: 594-19-4

Chemical Name:: tert-Butyllithium

Synonyms: T-BULI;T-BUTYLLITHIUM;TERT-BUTYLLITHIUM;LITHIUM TERT-BUTYL;Copper - titanium (1:1);Nominally1.5Minn-Pentane;tert-Butyllithium solution;(1,1-Dimethylethyl)lithium;(1,1-dimethylethyl)-lithiu;T-BuLi1.7Msolutioninpentane

CBNumber:: CB2229465

Molecular Formula:: C4H9Li

Molecular Weight:: 64.06

MDL Number:: MFCD00008795

MOL File:: 594-19-4.mol

Last updated:2026-01-13 11:17:03

Product description	Number	Pack Size	Price
tert-Butyllithium solution 1.7M in pentane	186198	4x25ml	$85.2
tert-Butyllithium solution 1.6-3.2?M in heptane	94439	100mL	$209
tert-Butyllithium solution 1.7M in pentane	186198	8l	$1463
t-Butyllithium 16% in pentane (1-2M)	93-0302	0.25mole	$89
t-Butyllithium 16% in pentane (1-2M)	93-0302	1mole	$264
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tert-Butyllithium Properties

Boiling point	36-40 °C
Density	0.69 g/mL at 20 °C
vapor density	~3 (vs air)
Flash point	20 °F
storage temp.	2-8°C
form	liquid
color	slightly cloudy
Sensitive	Air & Moisture Sensitive
BRN	3587204
Exposure limits	ACGIH: TWA 1000 ppm OSHA: TWA 1000 ppm(2950 mg/m3) NIOSH: IDLH 1500 ppm; TWA 120 ppm(350 mg/m3); Ceiling 610 ppm(1800 mg/m3)
InChI	InChI=1S/C4H9.Li/c1-4(2)3;/h1-3H3;
InChIKey	BKDLGMUIXWPYGD-UHFFFAOYSA-N
SMILES	C(C)(C)(C)[Li]
CAS DataBase Reference	594-19-4(CAS DataBase Reference)
EPA Substance Registry System	Lithium, (1,1-dimethylethyl)- (594-19-4)
UNSPSC Code	12352142
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS05,GHS07,GHS08,GHS09

Signal word

Danger

Hazard statements

H252-H318-H225-H250-H260-H304-H314-H336-H410-H411

Precautionary statements

P301+P310a-P303+P361+P353-P305+P351+P338-P405-P422a-P501a-P210-P222-P223-P231+P232-P370+P378-P422

target organs

Nervous system

Hazard Codes

F,C,N

Risk Statements

11-15-17-34-51/53-65-66-67-50/53-38-14/15

Safety Statements

26-36/37/39-43-45-62-61-16-33-9

RIDADR

UN 3394 4.2/PG 1

WGK Germany

3-10

TSCA

TSCA listed

HazardClass

4.3

PackingGroup

HS Code

29319090

Storage Class

4.2 - Pyrophoric and self-heating hazardous materials

Hazard Classifications

Aquatic Chronic 3
Asp. Tox. 1
Eye Dam. 1
Flam. Liq. 3
Pyr. Liq. 1
Repr. 2
Skin Corr. 1B
STOT RE 1 Inhalation
Water-react 1

NFPA 704

	4
3		2
	W

tert-Butyllithium price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	186198	tert-Butyllithium solution 1.7M in pentane	594-19-4	4x25ml	$85.2	2025-07-31	Buy
Sigma-Aldrich	94439	tert-Butyllithium solution 1.6-3.2?M in heptane	594-19-4	100mL	$209	2025-07-31	Buy
Sigma-Aldrich	186198	tert-Butyllithium solution 1.7M in pentane	594-19-4	8l	$1463	2025-07-31	Buy
Strem Chemicals	93-0302	t-Butyllithium 16% in pentane (1-2M)	594-19-4	0.25mole	$89	2024-03-01	Buy
Strem Chemicals	93-0302	t-Butyllithium 16% in pentane (1-2M)	594-19-4	1mole	$264	2024-03-01	Buy

Product number	Packaging	Price	Buy
186198	4x25ml	$85.2	Buy
94439	100mL	$209	Buy
186198	8l	$1463	Buy
93-0302	0.25mole	$89	Buy
93-0302	1mole	$264	Buy

tert-Butyllithium Chemical Properties,Uses,Production

Description

tert-Butyllithium solution (tert-BuLi) is an organolithium compound, used as a strong base in organic chemistry. It facilitates lithium-halogen exchange reaction and also can be employed in the deprotonation of C-H compounds and amines. it has applications in organic synthesis since it is a strong base, capable of deprotonating many carbon molecules, including benzene. tert-Butyllithium is available commercially as hydrocarbon solutions; it is not usually prepared in the laboratory. Its synthesis was first reported by R. B. Woodward in 1941.

Chemical Properties

tert-Butyllithium is a colorless crystalline solid or colourless to pale yellow solution. It is more reactive than n- or sec-butyllithium and has similar properties. However, it is thermally stable. Dixon and co-workers have heated tert-Butyllithium to 100°C for 20 hr with little decomposition.

Uses

There are no commercial uses of t-butyllithium, but it is used as a polymerization initiator and as a metalating agent in the laboratory.
Alkylating and metalating agent. Reagent for the introduction of the tert-butyl group.
tert-Butyllithium (t-BuLi) is the most reactive of the commercially available organolithium reagents. It is supplied as a standard solution in hydrocarbon solvents, usually in a bottle sealed with a septum.

Preparation

tert-Butyllithium is not sold in large quantities. The industrial and laboratory preparations are the same: the reaction of t-butyl chloride with lithium metal in a hydrocarbon solvent. However, tert-Butyllithium is much more difficult to produce than the other isomeric butyllithium compounds and some special precautions must be taken to obtain good yields. Principally, the lithium metal must be finely divided and must contain several percent sodium. It has also been found that t-butyl alcohol in the butyl chloride is beneficial. The solvent of choice is pentane. Vigorous reflux is necessary for good yield since it apparently helps to remove lithium chloride from the surface of the metal, and pentane refluxes at about the optimum temperature. If hexane is used at the same temperature, a significantly lower yield is obtained.

Application

tert-Butyllithium solution can be used as a strong base in the synthesis of:
Alkyllithium derivatives form alkyl iodides and diiodoalkanes by halogen-lithium exchange reaction.
Inorganic polymer [(LiMo3Se3)n] from [(InMo3Se3)n] by reductive intercalation method.
Adducts of cinnamic acid (1,3- and 1,4-adducts) by reacting with C-C double of cinnamic acid.

Structure and conformation

The crystal structure of tert-butyllithium exists as a tetrameric form, comprising four metallic lithium atoms forming a tetrahedral framework. Each face of this tetrahedron is connected to a tert-butyl group. The tertiary carbon atom of tert-butyl is bonded to three lithium metal atoms, establishing a distinctive bridging arrangement.
crystal structure of tert-butyllithium

tert-Butyllithium Preparation Products And Raw materials

Raw materials

2-Chloro-2-methylpropane Lithium Pentane

Preparation Products

Indole-5-carboxaldehyde 3-Bromofuran ETHYL 3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBONITRILE

(3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 5-CHLORO-3-METHYLBENZO[B]THIOPHENE-2-SULFONAMIDE 1-METHYL-1H-INDOLE-5-BORONIC ACID 2,2-DIMETHYL PROPANE DIOL-1,3-CYCLIC ESTER 3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-AMINE Di-tert-butylchlorophosphane

Tri-tert-butylphosphine tetrafluoroborate 3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-AMINE ORNOPROSTIL TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBALDEHYDE

(3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE 3-METHOXY-PYRIDINE-2-CARBALDEHYDE tert-Butyldimethylsilyl chloride 5-Acetylindole 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

(3-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONITRILE 1-TERT-BUTYL-4-BROMO-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE Indole-4-boronic acid DI-TERT-BUTYLDICHLOROSILANE

1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE (3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER 5-CHLORO-3-METHYLBENZO[B]THIOPHENE-2-SULFONYL CHLORIDE N-(6-FLUORO-3-FORMYLPYRIDIN-2-YL)PIVALAMIDE

4-BROMO-2-(TRIFLUOROMETHYL)-5-METHOXYPYRIDINE (1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE ETHYL 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-METHOXY-3-PYRIDINECARBOXALDEHYDE

5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE 3-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBALDEHYDE Tri-tert-butylphosphine 1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-AMINE (1-TERT-BUTYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANAMINE

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tert-Butyllithium Suppliers

Global( 229)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29833	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	1497	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7125	58
Baoji Guokang Healthchem Co., Ltd.	+86-0917-3909592 +86-13892490616	gksales1@gk-bio.com	China	9206	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Baoji Guokang Healthchem Co., Ltd.	58

View Lastest Price from tert-Butyllithium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-13	tert-Butyllithium 594-19-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	tert-Butyllithium 594-19-4	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	Tert-Butyllithium 594-19-4	US $1.00 / kg	1kg	99%	Customized	Career Henan Chemical Co

tert-Butyllithium
594-19-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

tert-Butyllithium
594-19-4
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Tert-Butyllithium
594-19-4
US $1.00 / kg
99%
Career Henan Chemical Co

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