Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>(-)-INDOLACTAM V

(-)-INDOLACTAM V

(-)-INDOLACTAM V Structure
(-)-INDOLACTAM V structure
CAS No.
90365-57-4
Chemical Name:
(-)-INDOLACTAM V
Synonyms
(-)-Ilv;IndolactaM;Brn 4711877;()-Indolactam V;(-)-Indolactam V;(-)-Indolactam V (-)-Indolactam V/Indolactam V;()Indolactam V,( ) Indolactam V;(-)-Indolactam V, PKC activator;(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl)
CBNumber:
CB2244996
Molecular Formula:
C17H23N3O2
Molecular Weight:
301.38
MDL Number:
MFCD00151197
MOL File:
90365-57-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-22 18:57:36
Product description Number Pack Size Price
(?)-Indolactam V ≥96% (HPLC) I0661 1mg $390
(−)-Indolactam V ≥95% 14647 500μg $174
(−)-Indolactam V ≥95% 14647 1mg $329
(-)-Indolactam V ≥95% 14647 500μg $158
(?)-Indolactam V ≥97% 14647 1mg $299
Request For Quotation

(-)-INDOLACTAM V Properties

Boiling point 584.0±50.0 °C(Predicted)
Density 1.166±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: >10mg/mL, clear
pka 14.39±0.10(Predicted)
form white powder
color White to light yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
InChI 1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1
InChIKey LUZOFMGZMUZSSK-LRDDRELGSA-N
SMILES CC(C)[C@@H]1N(C)c2cccc3[nH]cc(C[C@@H](CO)NC1=O)c23
FDA UNII 8CIY9O1323
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313
WGK Germany  3
RTECS  UY8547000
Storage Class 11 - Combustible Solids

(-)-INDOLACTAM V price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I0661 (?)-Indolactam V ≥96% (HPLC) 90365-57-4 1mg $390 2026-04-30 Buy
Cayman Chemical 14647 (−)-Indolactam V ≥95% 90365-57-4 500μg $174 2026-04-30 Buy
Cayman Chemical 14647 (−)-Indolactam V ≥95% 90365-57-4 1mg $329 2026-04-30 Buy
Cayman Chemical 14647 (-)-Indolactam V ≥95% 90365-57-4 500μg $158 2024-03-01 Buy
Cayman Chemical 14647 (?)-Indolactam V ≥97% 90365-57-4 1mg $299 2024-03-01 Buy
Product number Packaging Price Buy
I0661 1mg $390 Buy
14647 500μg $174 Buy
14647 1mg $329 Buy
14647 500μg $158 Buy
14647 1mg $299 Buy

(-)-INDOLACTAM V Chemical Properties,Uses,Production

Description

Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2Directs differentiation of human and mouse ESCs to pancreatic cells.3 May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5

Uses

(-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC). Weak tumor promoter. Also directs differentiation of human embryonic stem cells, potentially into pancreatic lineage allowing for an effective diabetes therapy.

Definition

ChEBI: (-)-indolactam V is a 9-membered ring that is a potent protein kinase C activator

Biological Activity

Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.

Biochem/physiol Actions

(-)-Indolactam V is a PKC activator shown to effect differentiation in embryonic stem cells leading to development of pancreatic precursors. It is active in the mouse model.

storage

-20°C (desiccate)

References

[1] H. FUJIKI. Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin.[J]. Philosophia (Ramat-Gan, Israel), 1984, 7 1: 866-870. DOI:10.20772/cancersci1959.75.10\_866
[2] JARI HEIKKILÄ  Karl E O Å. (−)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells[J]. Biochemical and biophysical research communications, 1989, 162 3: Pages 1207-1213. DOI:10.1016/0006-291x(89)90802-4
[3] SHUIBING CHEN. A small molecule that directs differentiation of human ESCs into the pancreatic lineage[J]. Nature chemical biology, 2009, 5 4: 258-265. DOI:10.1038/nchembio.154
[4] T THATAVA. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny[J]. Gene Therapy, 2010, 18 3: 283-293. DOI:10.1038/gt.2010.145
[5] AVI RAVEH. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts.[J]. Molecular Pharmacology, 2014, 86 4: 406-416. DOI:10.1124/mol.114.092403

(-)-INDOLACTAM V Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-INDOLACTAM V Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		+8613382787392 sales@aeechem.com China 10000 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15838 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7777 56
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51395 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
Haoyuan Chemexpress Co., Ltd. 61
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Sigma-Aldrich 80
Shanghai EFE Biological Technology Co., Ltd. 58

View Lastest Price from (-)-INDOLACTAM V manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(-)-Indolactam V pictures 2026-04-22 (-)-Indolactam V
90365-57-4
 US $748.00 / mg 10g TargetMol Chemicals Inc.

90365-57-4((-)-INDOLACTAM V)Related Search:

1,2-DIOCTANOYL-SN-GLYCEROL Prostratin, PKC activator Indometacin Pindolol INDOMETHACIN SODIUM SALT TRIHYDRATE
(+)-7-OCTYLINDOLACTAM V (-)-INDOLACTAM V 4-Aminoindole (+)-INDOLACTAM V N-[1-(AMINOMETHYL)-2-METHYLPROPYL]-N,N-DIMETHYLAMINE
LYNGBYATOXIN A (-)-7-OCTYLINDOLACTAM V Indolactam L Indolactam A 6-n-octyl-indolactam V
TELEOCIDINB-4 Indolactam TL Indolactam G

1of4

(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl) 3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym (2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one (-)-Ilv 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))- 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)- Brn 4711877 IndolactaM (-)-Indolactam V  ()-Indolactam V (-)-Indolactam V ()Indolactam V,( ) Indolactam V (2S,5S)-5-(Hydroxymethyl)-2-isopropyl-1-methyl-4,5,6,8-tetrahydro-1H-[1,4]diazonino[7,6,5-cd]indol-3(2H)-one (-)-Indolactam V, PKC activator (-)-Indolactam V/Indolactam V 90365-57-4