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Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate structure

CAS No.: 1224944-77-7

Chemical Name:: Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate

Synonyms: Loptinib intermediate;1224944-77-7;5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate;5-chloropyrazole[1,5-a]pyrimidine-3-ethylformate;thyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate;Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate;Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl este;Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester;5-Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl este;5-Chloro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

CBNumber:: CB22471280

Molecular Formula:: C9H8ClN3O2

Molecular Weight:: 225.63

MDL Number:: MFCD12407819

MOL File:: 1224944-77-7.mol

MSDS File:: SDS

Last updated:2026-05-28 00:04:23

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Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Properties

Density	1.47±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-2.44±0.40(Predicted)
Appearance	white to brown solid
InChI	InChI=1S/C9H8ClN3O2/c1-2-15-9(14)6-5-11-13-4-3-7(10)12-8(6)13/h3-5H,2H2,1H3
InChIKey	UOZKVCQDLXBWBG-UHFFFAOYSA-N
SMILES	C12=C(C(OCC)=O)C=NN1C=CC(Cl)=N2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
HS Code	2933599590

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FE44325	Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate	1224944-77-7	2000mg	$240	2026-06-04	Buy
Biosynth	FE44325	Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate	1224944-77-7	5000mg	$450	2026-06-04	Buy
Biosynth	FE44325	Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate	1224944-77-7	10000mg	$700	2026-06-04	Buy
Apolloscientific	OR49063	Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate >98%	1224944-77-7	1g	$21	2026-06-04	Buy
Apolloscientific	OR49063	Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate >98%	1224944-77-7	5g	$24	2026-06-04	Buy

Product number	Packaging	Price	Buy
FE44325	2000mg	$240	Buy
FE44325	5000mg	$450	Buy
FE44325	10000mg	$700	Buy
OR49063	1g	$21	Buy
OR49063	5g	$24	Buy

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Chemical Properties,Uses,Production

Uses

Ethyl 5-Chloropyrazolo[1,5-a]pyrimidine-3-carboxylate is used in preparation of antitumor pyrazolopyrimidine compound and it intermediates.

Synthesis

Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate

926663-00-5

1224944-77-7

Step B: Preparation of ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate; Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (22.7 g, 110 mmol) was suspended in phosphorus triclosan (100 mL) and heated to reflux. After maintaining the reflux reaction for 2 h, the reaction mixture was cooled and the excess phosphorous trichloride was removed by distillation under reduced pressure. The residue was diluted with dichloromethane (100 mL) and slowly poured into a flask containing ice water. The organic and aqueous layers were separated and the aqueous layer was further extracted with dichloromethane. All organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate (24.2 g, 97.6% yield) as a light yellow solid. Mass spectrum (APCI) m/z = 225.9 (M + H).

References

[1] Patent: WO2011/6074, 2011, A1. Location in patent: Page/Page column 70-71
[2] Chemical and Pharmaceutical Bulletin, 2017, vol. 65, # 11, p. 1058 - 1077
[3] Patent: WO2012/34095, 2012, A1. Location in patent: Page/Page column 68
[4] Patent: US2016/159808, 2016, A1. Location in patent: Paragraph 1357; 1358; 1381; 1382; 1394; 1395
[5] Patent: TW2016/520, 2016, A. Location in patent: Paragraph 0165

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Preparation Products And Raw materials

Raw materials

Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate

Preparation Products

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Suppliers

Global( 219)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Guoding Pharmaceutical Technology Co., Ltd.	053167801621 15665775653	sales@guodingpharma.com	China	479	58
Tongchuang Pharma(Suzhou). Co., Ltd.	0512-63263366 18912765016	tongtf110@sina.com	China	984	62
Shanghai Peiling Biological Technology Co., LTD	13127581762 13127581762	peilingchem@sina.com	China	465	58
Shandong Zhonghan Pharmaceutical Co.,Ltd.	15315818580 18562151612	2289008634@qq.com	China	295	55
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	13472757003	yongnan.wang@cendrix.cn	China	971	65
Jinan Dexinjia Bio&Tech Co., Ltd	0531-82375880 15098789112	3845379039@qq.com	China	1459	58
Changzhou Huanling Chemical Co., Ltd.	89803005 18206112582	info@huanlingchem.com	China	983	68
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7882	64

Supplier	Advantage
Jinan Guoding Pharmaceutical Technology Co., Ltd.	58
Tongchuang Pharma(Suzhou). Co., Ltd.	62
Shanghai Peiling Biological Technology Co., LTD	58
Shandong Zhonghan Pharmaceutical Co.,Ltd.	55
Shanghai Cuisen Pharmaceutical Technology Co., Ltd.	65
Jinan Dexinjia Bio&Tech Co., Ltd	58
Changzhou Huanling Chemical Co., Ltd.	68
Jia Xing Isenchem Co.,Ltd	66
Pure Chemistry Scientific Inc.	62
Tetranov Biopharm	64

View Lastest Price from Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate 1224944-77-7		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2024-11-26	Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate 1224944-77-7		1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd
2019-07-06	Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate 1224944-77-7	$1.00	1KG	99%		Career Henan Chemical Co

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
1224944-77-7
98%
Henan Aochuang Chemical Co.,Ltd.

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
1224944-77-7
98%
Nanjing Fred Technology Co., Ltd

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate
1224944-77-7
$1.00
99%
Career Henan Chemical Co

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate Spectrum

Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate(1224944-77-7)¹HNMR

1224944-77-7(Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate)Related Search:

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(5-Chloropyrazolo[1,5-a]pyrimidin-3-yl)methanol

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Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate 5-chloropyrazolo[1,5-a]pyriMidine-3-carboxylate 5-Chloro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester thyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate 5-Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl este Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5-chloro-, ethyl ester Loptinib intermediate Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester 1224944-77-7 Chloropyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl este 5-chloropyrazole[1,5-a]pyrimidine-3-ethylformate 1224944-77-7