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ChemicalBook >> CAS DataBase List >>4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide

4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide

4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Structure
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide structure
CAS No.
108477-18-5
Chemical Name:
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
Synonyms
NSC-144303;Ubiquitin Isopeptidase-IN-G5;Ubiquitin Isopeptidase Inhibitor I;G5, Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase Inhibitor I, G5;Ubiquitin Isopeptidase-IN-G5 (NSC-144303;3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide;tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-t;Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303);3,5-Bis(4-nitrobenzylidene)tetrahydro-4H-thiopyran-4-one 1,1-dioxide
CBNumber:
CB22489683
Molecular Formula:
C19H14N2O7S
Molecular Weight:
414.39
MDL Number:
MFCD28138111
MOL File:
108477-18-5.mol
MSDS File:
SDS
Last updated:2025-08-21 22:16:43
Product description Number Pack Size Price
Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem 662125 10MG $265
Ubiquitin Isopeptidase Inhibitor I ≥98% 21006 5mg $97
Ubiquitin Isopeptidase Inhibitor I ≥98% 21006 10mg $175
Ubiquitin Isopeptidase Inhibitor I ≥98% 21006 25mg $360
UbiquitinIsopeptidaseInhibitorI,G5 U700503 10mg $210
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4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Properties

Melting point 233.5-234.5 °C
Boiling point 693.0±55.0 °C(Predicted)
Density 1.541±0.06 g/cm3(Predicted)
storage temp. Store at -20°C,unstable in solution, ready to use.
solubility ≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
form crystalline solid
color Light yellow to yellow
UNSPSC Code 12352200
NACRES NA.54

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 662125 Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem 108477-18-5 10MG $265 2025-07-31 Buy
Cayman Chemical 21006 Ubiquitin Isopeptidase Inhibitor I ≥98% 108477-18-5 5mg $97 2024-03-01 Buy
Cayman Chemical 21006 Ubiquitin Isopeptidase Inhibitor I ≥98% 108477-18-5 10mg $175 2024-03-01 Buy
Cayman Chemical 21006 Ubiquitin Isopeptidase Inhibitor I ≥98% 108477-18-5 25mg $360 2024-03-01 Buy
TRC U700503 UbiquitinIsopeptidaseInhibitorI,G5 108477-18-5 10mg $210 2021-12-16 Buy
Product number Packaging Price Buy
662125 10MG $265 Buy
21006 5mg $97 Buy
21006 10mg $175 Buy
21006 25mg $360 Buy
U700503 10mg $210 Buy

4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Chemical Properties,Uses,Production

Description

Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 μM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 μM). It has also been shown to induce necrosis in apoptosis-resistant DKO cells.

Uses

Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated unsaturated dienone compound.

in vitro

ubiquitin isopeptidase inhibitor i targeted the ubiquitinproteasome system via inhibiting the ubiquitin isopeptidases. ubiquitin isopeptidase inhibitor i could induce a rather unique apoptotic pathway, including a bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the bh3-only protein noxa, stabilization of the inhibitor of apoptosis antagonist smac, but also the involvement of the death receptor pathway. moreover, the treatment of ubiquitin isopeptidase inhibitor i to cell extracts obtained from e1a cells did not inhibit the proteolytic activity of the proteasome, whereas mg-132 potently inhibited the cleavage of the llvy-amc substrate. in addition, noxa induction by ubiquitin isopeptidase inhibitor i could be inhibited by the specific rnai oligos efficiently. when apoptosis was scored, it was found that down-regulation of noxa was able to inhibit but did not suppress apoptosis and caspase activation in response to ubiquitin isopeptidase inhibitor i treatment [1].

IC 50

~30 μm

storage

Store at -20°C

References

[1] e. aleo, c. j. henderson, a. fontanini, et al. identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. cancer research 66(18), 9235-9244 (2006).

4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Preparation Products And Raw materials

Raw materials

Preparation Products

4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide Suppliers

Global( 59)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29799 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32434 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19908 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19961 58
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857 sales@fortunechem-sh.com China 984 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Supplier Advantage
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Nextpeptide Inc 		58
InvivoChem 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
VDM Biochemicals 64
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 58
Shanghai EFE Biological Technology Co., Ltd. 58

View Lastest Price from 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ubiquitin Isopeptidase Inhibitor I, G5 pictures 2025-08-21 Ubiquitin Isopeptidase Inhibitor I, G5
108477-18-5
 US $74.00-217.00 / mg 96.56% 10g TargetMol Chemicals Inc.
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide pictures 2019-12-24 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
108477-18-5
 US $1.00 / g 1g 99.99% 200kg Career Henan Chemical Co
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide NSC-144303 Ubiquitin Isopeptidase Inhibitor I Ubiquitin Isopeptidase Inhibitor I, G5 G5, Ubiquitin Isopeptidase Inhibitor I Ubiquitin Isopeptidase-IN-G5 Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303) Ubiquitin Isopeptidase Inhibitor I, G5,Ubiquitin Isopeptidase Inhibitor I, G-5 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide 3,5-Bis[(4-nitrophenyl)methylene]-2,3,5,6-tetrahydro-4H-thiopyran-4-one-1,1-dioxide tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-t 3,5-Bis(4-nitrobenzylidene)tetrahydro-4H-thiopyran-4-one 1,1-dioxide Ubiquitin Isopeptidase-IN-G5 (NSC-144303 108477-18-5 C19H14N2O7S