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ChemicalBook >> CAS DataBase List >>N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Structure
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide structure
CAS No.
925434-55-5
Chemical Name:
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
Synonyms
Sirt 1720;SRT 1720, 10 mM in DMSO;SRT1720 free base/ STR1720 HCl salt;SRT1720 - CAS 925434-55-5 - Calbiochem;N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide;N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide;2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-;N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide;Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide
CBNumber:
CB22489951
Molecular Formula:
C25H23N7OS
Molecular Weight:
469.56
MDL Number:
MFCD14584468
MOL File:
925434-55-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-01 19:06:17
Product description Number Pack Size Price
SRT1720 - CAS 925434-55-5 - Calbiochem
SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM). 		567860 10mg $270
SRT 1720 ≥98% 42531 5mg $58
SRT 1720 ≥98% 42531 10mg $87
SRT 1720 ≥98% 42531 25mg $174
SRT 1720 ≥98% 42531 50mg $319
More product size
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N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Properties

Melting point 221℃
Density 1.46
storage temp. -20C
solubility DMSO:5.0(Max Conc. mg/mL);10.65(Max Conc. mM)
form Yellow solid
pka 11.19±0.70(Predicted)
color Light yellow to yellow
InChIKey IASPBORHOMBZMY-UHFFFAOYSA-N
SMILES O=C(C1=NC(C=CC=C2)=C2N=C1)NC3=CC=CC=C3C4=CN5C(SC=C5CN6CCNCC6)=N4
FDA UNII DX3FHY76FZ
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 567860 SRT1720 - CAS 925434-55-5 - Calbiochem
SRT1720, CAS 925434-55-5, is a cell-permeable inhibitor of the mitochondrial SIRT3. Inhibition is AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM). 		925434-55-5 10mg $270 2026-04-30 Buy
Cayman Chemical 42531 SRT 1720 ≥98% 925434-55-5 5mg $58 2026-04-30 Buy
Cayman Chemical 42531 SRT 1720 ≥98% 925434-55-5 10mg $87 2026-04-30 Buy
Cayman Chemical 42531 SRT 1720 ≥98% 925434-55-5 25mg $174 2026-04-30 Buy
Cayman Chemical 42531 SRT 1720 ≥98% 925434-55-5 50mg $319 2026-04-30 Buy
Product number Packaging Price Buy
567860 10mg $270 Buy
42531 5mg $58 Buy
42531 10mg $87 Buy
42531 25mg $174 Buy
42531 50mg $319 Buy

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Chemical Properties,Uses,Production

Uses

SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively.

General Description

A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56 μM; Km = 2.44 μM), but NAD+-uncompetitive (Ki = 0.34 μM; Km = 280 μM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10 μM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9 μM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100 mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Also available as a 25 mM solution in DMSO (Cat. No. 530748).

in vivo

SRT 1720 (10, 30, 100 mg/kg, p.o.) significantly reduces the hyperinsulinaemia after 4 weeks, partially normalizing elevated insulin levels similar to rosiglitazone treatment. SRT 1720 treatment significantly reduces fasting blood glucose to near normal levels in Lepob/ob mice[1]. SRT 1720 has ability to protect against the negative effects of diet-induced obesity in mice, and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1[2]. SRT 1720 (50-100 mg/kg, p.o.), during emphysema development attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice[3].

IC 50

SIRT1: 0.16 μM (EC1.5); SIRT2: 37 μM (EC1.5)

storage

Store at -20°C

References

[1] Milne JC et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29;450(7170):712-6 DOI:10.1038/nature06261
[2] Baur JA, et al. Are sirtuins viable targets for improving healthspan and lifespan Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61 DOI:10.1038/nrd3738
[3] Yao H, et al. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest. 2012 Jun 1;122(6):2032-45. DOI:10.1172/JCI60132
[4] Yu L, et al. Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury. Toxicol Lett. 2016 Dec 15;264:1-11. DOI:10.1016/j.toxlet.2016.10.016

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide synthesis

6851-99-6
925434-55-5
Synthesis of N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide from 2-Bromo-2'-nitroacetophenone

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Preparation Products And Raw materials

Raw materials

tert-butyl 4-((6-(2-aMinophenyl)iMidazo[2,1-b]thiazol-3-yl)Methyl)piperazine-1-carboxylate 6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE-3-CARBOXYLIC ACID (6-(2-nitrophenyl)iMidazo[2,1-b]thiazol-3-yl)Methyl Methanesulfonate 6-(2-NITRO-PHENYL)-IMIDAZO[2,1-B]THIAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 3-HYDROXYMETHYL-6-(2-NITROPHENYL)IMIDAZO[2,1-B]THIAZOLE
2-QUINOXALINECARBONYL CHLORIDE 4-[[6-[2-[(2-QUINOXALINYLCARBONYL)AMINO]PHENYL]IMIDAZO [2,1-B]THIAZOL-3-YL]METHYL]-1-PIPERAZINECARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER 2-Bromo-2'-nitroacetophenone

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Preparation Products

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Suppliers

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29794 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32467 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
RR Scientific LLC 		+86-13917743231 sales@rrscientific.com United States 878 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39040 58
Shaanxi Dideu New Materials Co. Ltd 		+86-18192503167 18192503167; 1036@dideu.com China 7917 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
RR Scientific LLC 		58
TargetMol Chemicals Inc. 		58
Shaanxi Dideu New Materials Co. Ltd 		58

View Lastest Price from N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SRT 1720 pictures 2026-04-30 SRT 1720
925434-55-5
 US $31.00-68.00 / mg 99.70% 10g TargetMol Chemicals Inc.
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide pictures 2025-12-01 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
925434-55-5
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide pictures 2020-02-19 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide
925434-55-5
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co
  • SRT 1720 pictures
  • SRT 1720
    925434-55-5
  • US $31.00-68.00 / mg
  • 99.70%
  • TargetMol Chemicals Inc.

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide Spectrum

N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide(925434-55-5)1HNMR

925434-55-5(N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide)Related Search:

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SR17018 SRT3025 SRT2104 (GSK2245840) SR 3029 SR 16832
SR8278 SR-4835 SR-9243

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N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide 2-QuinoxalinecarboxaMide, N-[2-[3-(1-piperazinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]- Quinoxaline-2-carboxylic acid [2-(3-piperazin-1-ylmethyl-imidazo[2,1-b]thiazol-6-yl)-phenyl]-amide SRT1720 free base/ STR1720 HCl salt SRT1720 - CAS 925434-55-5 - Calbiochem N-[2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]quinoxaline-2-carboxamide SRT 1720, 10 mM in DMSO Sirt 1720 925434-55-5 5434-55-5 C25H23N7OS