3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol
- CAS No.
- 947144-26-5
- Chemical Name:
- 3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol
- Synonyms
- 3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol;6-trifluoromethyl-3-nitro-2,4-dihydroxypyridine;4-Hydroxy-3-nitro-6-(trifluoromethyl)-2(1H)-pyridinone;2(1H)-Pyridinone, 4-hydroxy-3-nitro-6-(trifluoromethyl)-
- CBNumber:
- CB22490966
- Molecular Formula:
- C6H3F3N2O4
- Molecular Weight:
- 224.09
- MDL Number:
- MFCD14706616
- MOL File:
- 947144-26-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00IIDV | 3-Nitro-6-(Trifluoromethyl)Pyridine-2,4-Diol 97% | 947144-26-5 | 100mg | $112 | 2026-05-29 | Buy |
| aablocks | AA00IIDV | 3-Nitro-6-(Trifluoromethyl)Pyridine-2,4-Diol 97% | 947144-26-5 | 250mg | $184 | 2026-05-29 | Buy |
| aablocks | AA00IIDV | 3-Nitro-6-(Trifluoromethyl)Pyridine-2,4-Diol 97% | 947144-26-5 | 1g | $457 | 2026-05-29 | Buy |
| ACHEMBLOCK | X206778 | 4-hydroxy-3-nitro-6-(trifluoromethyl)-1H-pyridin-2-one 95% | 947144-26-5 | 250MG | $280 | 2026-05-27 | Buy |
| ACHEMBLOCK | X206778 | 4-hydroxy-3-nitro-6-(trifluoromethyl)-1H-pyridin-2-one 95% | 947144-26-5 | 1G | $695 | 2026-05-27 | Buy |
3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol Chemical Properties, Uses, Production
Synthesis
947144-32-3
947144-26-5
General procedure for the synthesis of 3-nitro-6-(trifluoromethyl)pyridine-2,4-diol from 4-hydroxy-6-(trifluoromethyl)pyridine-2(1H)pyridone: 3-trifluoromethyl-pyridine-2,4-diol (56 g, 310 mmol) was added in batches of 3-5 g at a time under stirring conditions to concentrated sulfuric acid (140 mL) to give a light brown solution. During the addition, the reaction temperature was raised to about 50°C. Subsequently, nitric acid (21.1 mL, 328 mmol, 70% HNO3, density = 1.4 g/mL) was added dropwise, with a controlled titration rate to maintain the reaction temperature between 45°C and 50°C. The titration process took about 90 minutes. After the addition of nitric acid, the reaction mixture was allowed to cool naturally to room temperature over a period of 3 hours. The reaction mixture was poured into an ice/water mixture (about 1.3 kg) with stirring and a light yellow precipitate precipitated after a few minutes. The precipitate was collected by filtration, dissolved in ethyl acetate, dried over sodium sulfate, filtered and the solvent evaporated. A second batch of product was obtained by extracting the aqueous filtrate with ethyl acetate. The two batches of product were combined and purified by crystallization from a mixed ethyl acetate/n-heptane solvent to give the final 3-nitro-6-trifluoromethyl-pyridine-2,4-diol as a white fluffy solid (49.5 g, 71% yield).
References
[1] Patent: WO2008/47201, 2008, A2. Location in patent: Page/Page column 32
[2] Patent: US2007/197478, 2007, A1. Location in patent: Page/Page column 50
3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol Preparation Products And Raw materials
Raw materials
Preparation Products
3-Nitro-6-(trifluoromethyl)pyridine-2,4-diol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-58859352 15955137747 | sales01@aikonchem.com | China | 16021 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 9999 | 58 |
| Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd. | 15990591583 | China | 6129 | 58 | |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1982 | 58 |
| Shanghai Sunway Pharmaceutical Technology Co.,Ltd. | 13611835272 13611835272 | mmwang@sunwaypharm.com | China | 44090 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39796 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39645 | 58 |
| Shanghai Zhongzechuan Pharmaceutical Technology Co., LTD | 25888888 15021253307 | sales@wesyntech.com | China | 498 | 58 |
| Shanghai Yanbang Pharmaceutical Technology Co., Ltd | 15618536883 | 1228181347@qq.com | China | 7948 | 58 |
