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Mirabegron

Mirabegron Structure
Mirabegron structure
CAS No.
223673-61-8
Chemical Name:
Mirabegron
Synonyms
Mirabelon;YM 178;CS-732;Betmiga;Mirabello;Mirabegron;MIRABEQRON;Mira veron;Mirabregon;Mirabellon
CBNumber:
CB22493967
Molecular Formula:
C21H24N4O2S
Molecular Weight:
396.51
MDL Number:
MFCD11100356
MOL File:
223673-61-8.mol
MSDS File:
SDS
Last updated:2026-01-30 17:41:12
Product description Number Pack Size Price
Mirabegron ≥98% (HPLC) SML2480 5MG $112.1
Mirabegron CRS, European Pharmacopoeia (EP) Reference Standard Y0002371 120 mg $141
Mirabegron ≥98% (HPLC) SML2480 25MG $474.05
Mirabegron CRS, European Pharmacopoeia (EP) Reference Standard Y0002371 Y0002371 $132
Mirabegron M3567 1G $167
More product size
Request For Quotation

Mirabegron Properties

Melting point 138-140°C
Boiling point 690.0±55.0 °C(Predicted)
Density 1.313
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly, Heated), Methanol (Slightly)
pka 13.51±0.70(Predicted)
form Solid
color White to Pale Yellow
optical activity [α]/D -16 to -22°, c =0.5 in methanol
InChI 1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
InChIKey PBAPPPCECJKMCM-IBGZPJMESA-N
SMILES S1C=C(CC(NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=O)N=C1N
CAS DataBase Reference 223673-61-8
FDA UNII MVR3JL3B2V
ATC code G04BD12
NCI Drug Dictionary mirabegron
UNSPSC Code 41116107
NACRES NA.77

Pharmacokinetic data

Protein binding 71%
Excreted unchanged in urine 25%
Volume of distribution 1670 Litres
Biological half-life 50 / Increased

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H361d
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids
Hazard Classifications Repr. 2
NFPA 704
0
2 0

Mirabegron price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML2480 Mirabegron ≥98% (HPLC) 223673-61-8 5MG $112.1 2025-07-31 Buy
Sigma-Aldrich Y0002371 Mirabegron CRS, European Pharmacopoeia (EP) Reference Standard 223673-61-8 120 mg $141 2025-07-31 Buy
Sigma-Aldrich SML2480 Mirabegron ≥98% (HPLC) 223673-61-8 25MG $474.05 2025-07-31 Buy
Sigma-Aldrich Y0002371 Mirabegron CRS, European Pharmacopoeia (EP) Reference Standard 223673-61-8 Y0002371 $132 2024-03-01 Buy
TCI Chemical M3567 Mirabegron 223673-61-8 1G $167 2025-07-31 Buy
Product number Packaging Price Buy
SML2480 5MG $112.1 Buy
Y0002371 120 mg $141 Buy
SML2480 25MG $474.05 Buy
Y0002371 Y0002371 $132 Buy
M3567 1G $167 Buy

Mirabegron Chemical Properties,Uses,Production

Description

Betanis (Mirabegron) was approved in July 2011 by the Japanese Ministry of Health, Labour, and Welfare for the treatment of urgency, urinary frequency, and urinary urge urinary incontinence associated with overactive bladder (OAB). Mirabegron is synthesized by coupling 4-nitrophenethyl amine to (R)-2-hydroxy-2-phenylacetic acid. The resulting amide is reduced to an amine. The nitro group is then reduced and the resulting aniline is coupled to 2-(2-aminothiazol-4-yl) acetic acid to give mirabegron. Mirabegron has an EC50 of 22 nM (intrinsic activity=0.8) for β3-AR with no detectable activity for β1- andβ2-AR (EC50>10,000 nM). In an anesthetized rat rhythmic bladder contraction model in which bladder contractions are induced by saline, mirabegron at 3 mg/kg iv decreased the frequency of rhythmic bladder contraction without suppressing contraction amplitude. These data suggest that the activation of β3-AR increases bladder capacity without influencing the frequency of bladder contraction.

Chemical Properties

White to Off-White Solid

Originator

Astellas Pharma Inc. (Japan)

Uses

Mirabegron is a selective β3-adrenoceptor agonist with EC50 of 22.4 nM.

Uses

A potent bladder relaxant compound

Uses

Potent bladder relaxant and reagent for diabetes remedy.;Labeled Mirabegron, intended for use as an internal standard for the quantification of Mirabegron by GC- or LC-mass spectrometry.

Definition

ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-amino-1,3-thiazol-4-ylacetic acid with the anilino group of (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethanol. Used for the treatment of overactive ladder syndrome.

brand name

Betanis

Clinical Use

Mirabegron is an orally active β3-adrenoceptor agonist currently in development by Astellas Pharma for the treatment of overactive bladder (OAB). The drug is a nanomolar EC50 antagonist against human β3-AR biochemical assays with good selectivity over b1- and β2-ARs. Mirabegron demonstrates a novel mechanism by targeting the β3-AR for bladder relaxation to help manage OAB symptoms such as increased urinary urgency and frequency and urgency incontinence. However, mirabegron is a cytochrome P450 2D6 inhibitor, and it raises a concern for drug–drug interaction with concomitant administration of other cytochrome P450 2D6 substrates.

Synthesis

The synthesis of mirabegron began with a condensation reaction between (R)-styrene oxide (182) and 4-nitrophenylethylamine (183) in refluxing isopropanol to yield corresponding aminoalcohol 184 in 22% yield. Aminoalcohol 184 was protected as its N-Boc derivative with t-butyl dicarbonate in THF in 96% yield, and this was followed by nitro group hydrogenative reduction with 10% Pd/C to give free amine 185 in 96% yield. Aniline 185 was coupled with 2-amino-4-thiazolyl acetic acid 186 in the presence of EDCI and HOBt to give amide 187 in 85% yield. Removal of the Boc group was affected with 4 N HCl solution in a 2:1 volume ratio in ethyl acetate to obtain mirabegron HCl in 52% yield. The HCl salt was neutralized with 1 N NaOH to deliver mirabegron (XVII).

Synthesis_223673-61-8

Drug interactions

Potentially hazardous
interactions with other drugs None known

Metabolism

Metabolised via multiple pathways involving dealkylation, oxidation, (direct) glucuronidation, and amide hydrolysis. Renal elimination of mirabegron is primarily through active tubular secretion along with glomerular filtration.

storage

Store at -20°C

Mirabegron synthesis

29676-71-9
521284-22-0
223673-61-8
Synthesis of Mirabegron from 2-Aminothiazole-4-acetic acid and (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride

Mirabegron Preparation Products And Raw materials

Raw materials

BenzeneMethanol, a-[[[2-(4-aMinophenyl)ethyl]aMino]Methyl]-, (aR)- (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride 2-Aminothiazole-4-acetic acid

Preparation Products

Mirabegron Suppliers

Global( 528)Suppliers
Supplier Tel Email Country ProdList Advantage
Anhui Dexinjia Biopharm Co., Ltd
+86-531-82375818 +86-15064153060 sales01@jndxj.com China 318 58
Beijing Mesochem Technology Co.,Ltd
+8613651027935 rachel@mesochem.com China 191 58
Shenzhen Excellent Biomedical Technology Co.,Ltd.
+86-0755-26050679 15915472436 sale@ex-biotech.cn China 1023 58
HangZhou RunYan Pharma Technology Co.,LTD.
+8618882027439 sales2@runyanpharma.com China 302 58
Zhejiang Hengkang Pharmaceutical Co.Ltd.
+8615168202657 commercial@hengkangpharm.cn China 42 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8749 58
shandong perfect biotechnology co.ltd 		+86-53169958659 +86-13153181156 sales@sdperfect.com China 294 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829 justine@zhongda-biotech.com China 286 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 sales@sjar-tech.com China 521 58
Supplier Advantage
Anhui Dexinjia Biopharm Co., Ltd
58
Beijing Mesochem Technology Co.,Ltd
58
Shenzhen Excellent Biomedical Technology Co.,Ltd.
58
HangZhou RunYan Pharma Technology Co.,LTD.
58
Zhejiang Hengkang Pharmaceutical Co.Ltd.
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
shandong perfect biotechnology co.ltd 		58
Anhui Zhongda Biotechnology Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		58

Related articles

View Lastest Price from Mirabegron manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mirabegron pictures 2026-03-14 Mirabegron
223673-61-8
 0.99 RongNa Biotechnology Co.,Ltd
Mirabegron pictures 2026-03-13 Mirabegron
223673-61-8
 US $0.00 / g 1g 99%min 1000g WUHAN FORTUNA CHEMICAL CO., LTD
Mirabegron pictures 2026-03-12 Mirabegron
223673-61-8
 US $0.00 / g 1g More Than 99% 100kg/Month BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
  • Mirabegron pictures
  • Mirabegron
    223673-61-8
  • 0.99
  • RongNa Biotechnology Co.,Ltd
  • Mirabegron pictures
  • Mirabegron
    223673-61-8
  • US $0.00 / g
  • 99%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Mirabegron pictures
  • Mirabegron
    223673-61-8
  • US $0.00 / g
  • More Than 99%
  • BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Mirabegron Spectrum

Mirabegron(223673-61-8)1HNMR

223673-61-8(Mirabegron)Related Search:

(R)-2-(2-aminothiazol-4-yl)-N-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)acetamide Mirabegron Deshydroxy Mirabegron Impurity 4 (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide (alphaR)-alpha-[[[2-(4-Aminophenyl)ethyl]amino]methyl]benzenemethanol hydrochloride
(alphaR)-alpha-[[[2-(4-Nitrophenyl)ethyl]amino]methyl]benzenemethanol BenzeneMethanol, -[[[2-(4-nitrophenyl)ethyl]aMino]Methyl]-, (R)- Mirabegron Impurity Mirabegron Impurity Bestatin
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1of4

2-AMino-N-[4-[2-[[(2R)-2-hydroxy-2-phenyl-ethyl]aMino]-ethyl]phenyl]-4-thiazoleacetaMide 2-(2-aMino-1,3-thiazol-4-yl)-N-(4-{2-[(2-hydroxy-2-phenylethyl)aMino]ethyl}phenyl)acetaMide (2R)-2-(2-AMinothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)aMino]ethyl]acetic Acid Anilide 4-Thiazoleacetamide, 2-amino-N-(4-(2-(((2R)-2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)- Mirabegron N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)-2-(2-aminothiazol-4-yl)acetamide YM 178 Mirabegron(YM 178) MIRABEQRON Merariveron impurity B 2-(2-Amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy2-phenylethyl]amino}ethyl)phenyl]acetamide Mirabegron, >=99% Mira veron (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl}acetanilide (R)-2-(2-aminothiazol-4-yl)-N-(4-(2-(2-hydroxy-2-phenylethylamino)ethyl)phenyl)acetamide CS-732 Mirabelon Mirabello Mirabregon Mirabegron Intermediates hot selling Mirabegron Mirabegron USP/EP/BP Mirabegron (API) (R)-N-(4-(2-(2-aminothiazol-4-yl)acetamido)phenethyl)-2-hydroxy-2-phenylacetamide Mirabegron-d8 (R)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)-2-(2-imino-2,3-dihydrothiazol-4-yl)acetamide MirabegronQ: What is Mirabegron Q: What is the CAS Number of Mirabegron Q: What is the storage condition of Mirabegron Q: What are the applications of Mirabegron Mirabellon Betmiga Benzenamine,N,N,3,11-tetramethyl- 1-Pyrrolidinepropanoicacid,2,6-dioxo- Merabegron Mirabegron (Alpha and Amorphous) Mirabegron, 10 mM in DMSO Mirabegron Sustained-release Tablets Mirabegron racemate CRS Mirabegron CRS 223673-61-8 23673-61-8 Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds 223673-61-8 API