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IPI-926

IPI-926 Structure
IPI-926 structure
CAS No.
1037210-93-7
Chemical Name:
IPI-926
Synonyms
Saridegib;IP 9;FIN 5;IPI-926;Patidegib);Saridegib (IPI-926;IPI-926 (SARIDEGIB);Saridegib (Synonyms: IPI-926;N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide;N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethyl-2,3,3'a,4,4',4a,5,5',6,6',6a,6b,7,7',7'a,8,10,12,12a,12b-icosahydro-1H,3'H-spiro[azuleno[2,1-a]naphthalene-9,2'-furo[3,2-b]pyridin]-3-yl]methanesulfonamide
CBNumber:
CB22506021
Molecular Formula:
C29H48N2O3S
Molecular Weight:
504.77
MDL Number:
MFCD26960900
MOL File:
1037210-93-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:38
Product description Number Pack Size Price
Saridegib MRB21093 50mg $11000
Saridegib MRB21093 100mg $16500
Saridegib 99.95% CS-0007501 1mg $737
Saridegib 99.95% CS-0007501 5mg $2752
Saridegib >98% AA009243 1mg $791
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IPI-926 Properties

Boiling point 617.7±65.0 °C(Predicted)
Density 1.17±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 10.85±0.70(Predicted)
form Solid
color White to off-white
FDA UNII JT96FPU35X
NCI Drug Dictionary patidegib

IPI-926 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth MRB21093 Saridegib 1037210-93-7 50mg $11000 2026-06-04 Buy
Biosynth MRB21093 Saridegib 1037210-93-7 100mg $16500 2026-06-04 Buy
ChemScene CS-0007501 Saridegib 99.95% 1037210-93-7 1mg $737 2026-06-04 Buy
ChemScene CS-0007501 Saridegib 99.95% 1037210-93-7 5mg $2752 2026-06-04 Buy
aablocks AA009243 Saridegib >98% 1037210-93-7 1mg $791 2026-05-28 Buy
Product number Packaging Price Buy
MRB21093 50mg $11000 Buy
MRB21093 100mg $16500 Buy
CS-0007501 1mg $737 Buy
CS-0007501 5mg $2752 Buy
AA009243 1mg $791 Buy

IPI-926 Chemical Properties,Uses,Production

Uses

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Definition

ChEBI: Patidegib is a member of piperidines.

in vivo

Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model[1].

References

[1] Ko AH, et al. A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma. Pancreas. 2016 Mar;45(3):370-5. DOI:10.1097/MPA.0000000000000458

IPI-926 Preparation Products And Raw materials

Raw materials

Preparation Products

IPI-926 Suppliers

Global( 35)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19935 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +86-15965530500 nickzhang@hangyubiotech.com China 9932 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4855 55
Chuzhou KeMail Chemical Technology Co., Ltd 0550-5196001 15000891977 wj520wjxby@126.com China 1940 55
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9855 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646 shoubull@126.com China 892 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2936 58
Supplier Advantage
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Chuzhou KeMail Chemical Technology Co., Ltd 55
Chunchuang (Wuhan) Technology Co., Ltd 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Tachizaki Biomedical Research Center 58

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IPI-926 FIN 5 IP 9 N-[(2S,3R,3'R,3aS,4'aR,6S,6'aR,6'bS,7aR,12'aS,12'bS)-2',3',3a,4,4',4'a,5,5',6,6',6'a,6'b,7,7',7a,8',10',12',12'a,12'b-Eicosahydro-3,6,11',12'b-tetramethylspiro[furo[3,2-b]pyridine-2(3H),9'(1'H)-naphth[2,1-a]azulen]-3'-yl]-methanesulfonamide N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethylspiro[1,2,3,4,4a,5,6,6a,6b,7,8,10,12,12a-tetradecahydronaphtho[2,1-a]azulene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-yl]methanesulfonamide Saridegib (IPI-926 IPI-926 (SARIDEGIB) Patidegib) Saridegib (Synonyms: IPI-926 Methanesulfonamide, N-[(2S,3R,3'R,3aS,4'aR,6S,6'aR,6'bS,7aR,12'aS,12'bS)-2',3',3a,4,4',4'a,5,5',6,6',6'a,6'b,7,7',7a,8',10',12',12'a,12'b-eicosahydro-3,6,11',12'b-tetramethylspiro[furo[3,2-b]pyridine-2(3H),9'(1'H)-naphth[2,1-a]azulen]-3'-yl]- N-[(3R,3'R,3'aS,4aR,6'S,6aR,6bS,7'aR,9S,12aS,12bS)-3',6',11,12b-tetramethyl-2,3,3'a,4,4',4a,5,5',6,6',6a,6b,7,7',7'a,8,10,12,12a,12b-icosahydro-1H,3'H-spiro[azuleno[2,1-a]naphthalene-9,2'-furo[3,2-b]pyridin]-3-yl]methanesulfonamide Saridegib 1037210-93-7 C29H48N2O3S