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Dexrazoxane

Dexrazoxane Structure
Dexrazoxane structure
CAS No.
24584-09-6
Chemical Name:
Dexrazoxane
Synonyms
DEXTRAZOXANE;adr529;cardioxane;DEXRAZOXANE;(S)-ICRF-187;DEXTRORAZOXANE;Dexrazoxane>Right razoxane;(+)-dexrazoxane;Dextropropimine
CBNumber:
CB2251448
Molecular Formula:
C11H16N4O4
Molecular Weight:
268.27
MDL Number:
MFCD00866449
MOL File:
24584-09-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:01:57
Product description Number Pack Size Price
Dexrazoxane ≥95% (HPLC) D1446 5mg $117
Dexrazoxane analytical standard 05587 25mg $101
Dexrazoxane >98.0%(T) D4227 100mg $60
Dexrazoxane ≥98% 14632 5mg $36
Dexrazoxane ≥98% 14632 10mg $53
More product size
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Dexrazoxane Properties

Melting point 194-196°C
alpha D +11.35° (c = 5 in DMF)
Boiling point 531.5±50.0 °C(Predicted)
Density 1.333±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form powder
pka 2.1(at 25℃)
color white to off-white
Merck 14,8123
Henry's Law Constant 4.7×1013 mol/(m3Pa) at 25℃, HSDB (2015)
Major Application clinical testing
InChI InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1
InChIKey BMKDZUISNHGIBY-ZETCQYMHSA-N
SMILES [C@H](N1CC(=O)NC(=O)C1)(C)CN1CC(=O)NC(=O)C1
CAS DataBase Reference 24584-09-6(CAS DataBase Reference)
FDA UNII 048L81261F
ATC code V03AF02
UNSPSC Code 41116107
NACRES NA.24

Pharmacokinetic data

Protein binding 2%
Excreted unchanged in urine Cardioxane : 40; Savene : 34-60%
Volume of distribution 0.13-1.3(L/kg)
Biological half-life Cardioxane : 1-3.4; Savene : 1.9-9.1 / Increased

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS  TL6390000
HS Code  2933.59.9500
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazardous Substances Data 24584-09-6(Hazardous Substances Data)
NFPA 704
0
2 0

Dexrazoxane price More Price(107)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D1446 Dexrazoxane ≥95% (HPLC) 24584-09-6 5mg $117 2026-04-30 Buy
Sigma-Aldrich 05587 Dexrazoxane analytical standard 24584-09-6 25mg $101 2026-04-30 Buy
TCI Chemical D4227 Dexrazoxane >98.0%(T) 24584-09-6 100mg $60 2026-04-30 Buy
Cayman Chemical 14632 Dexrazoxane ≥98% 24584-09-6 5mg $36 2026-04-30 Buy
Cayman Chemical 14632 Dexrazoxane ≥98% 24584-09-6 10mg $53 2026-04-30 Buy
Product number Packaging Price Buy
D1446 5mg $117 Buy
05587 25mg $101 Buy
D4227 100mg $60 Buy
14632 5mg $36 Buy
14632 10mg $53 Buy

Dexrazoxane Chemical Properties,Uses,Production

Description

Dexrazoxane is the dextro-isomer of razoxane approved as a protectant against the cardiotoxicity of doxorubicin in breast cancer patients. This agent does not alter the anticancer effect of doxorubicin. Its mode of action suggests a chelation of free radicals. In mice, dexrazoxane also offers protection against cardiac side effects of epirubicin, but not mitoxantrone.

Originator

Imperial Cancer Research Fund (United Kingdom)

Uses

Dexrazoxane is a cardioprotective compound against anthracyclines. It is highly protective in reducing anthracycline-induced cardiotoxicity and extravasation injury. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Uses

Dexrazoxane has been used in chromatin remodelling experiments.

Uses

Cardioprotectant.

Definition

ChEBI: (+)-dexrazoxane is a razoxane. It has a role as a chelator, an antineoplastic agent, a cardiovascular drug and an immunosuppressive agent.

brand name

Zinecard (Pharmacia & Upjohn);Cardioxane.

General Description

Dexrazoxane is a member of bis(2,6-dioxopiperazines), that functions as a topoisomerase 2 catalytic inhibitor. Dexrazoxane is a free radical scavenger. It might protect the heart from doxorubicin-associated damage. Dexrazoxane acts as a cardiopulmonary protectant, while treating Hodgkin′s disease (HD). It functions as a chelating agent, which limits the formation of anthracycline-iron complexes. It is used to synthesize antimalarial drugs.

Biological Activity

Topoisomerase II inhibitor and intracellular ion chelator. Bridges and stabilizes an interface between two ATPase promoters to inhibit topoisomerase II activity. Cardioprotective when co-administered with doxorubicin; decreases formation of reactive oxygen species (ROS) and activates the PI3K/Akt survival pathway.

Biochem/physiol Actions

Dexrazoxane is a cardioprotective compound against anthracyclines. It functions by inhibiting topoisomerase II without inducing DNA strand breaks. Dexrazoxane is a + enantiomer of razoxane.

Clinical Use

Cardioxane Prevention of cardiotoxicity in patients receiving doxorubicin or epirubicin for breast cancer Savene : Treatment of extravasation caused by anthracyclines

Veterinary Drugs and Treatments

Dexrazoxane may be useful to attenuate the cardiotoxic effects of doxorubicin in patients who are showing signs of anthracycline cardiotoxicity, have cardiac disease, or are at maximum cumulative dosages of doxorubicin. It is also used to treat extravasation injuries associated with doxorubicin.
While dexrazoxane has been shown to be cardioprotective when given at dosages of 10 times the doxorubicin dose, there is evidence that it may also partially protect the cancer cells being treated.

Drug interactions

Potentially hazardous interactions with other drugs
Antiepileptics: may reduce absorption of fosphenytoin and phenytoin.
Ciclosporin: increased risk of immunosuppression with risk of lymphoproliferative disease.
Tacrolimus: increased risk of immunosuppression with risk of lymphoproliferative disease.
Vaccines: risk of generalised infections with live vaccines - avoid.

Metabolism

Dexrazoxane is hydrolysed by the enzyme dihydropyrimidine amidohydrolase in the liver and kidney to active metabolites that are capable of binding to metal ions.
It is excreted unchanged via the kidney

Dexrazoxane synthesis

15250-41-6
24584-09-6
Synthesis of Dexrazoxane from (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid

Dexrazoxane Preparation Products And Raw materials

Raw materials

Preparation Products

Dexrazoxane Suppliers

Global( 344)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Hangzhou Hyper Chemicals Limited 		+86-0086-57187702781 +8613675893055 info@hyper-chem.com China 310 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13901 58
Shanghai Zheyan Biotech Co., Ltd. 		18017610038 zheyansh@163.com CHINA 3619 58
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29815 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-87569266 +86-17392581500 1015@dideu.com China 3991 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hangzhou Hyper Chemicals Limited 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
Shanghai Zheyan Biotech Co., Ltd. 		58
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Shaanxi Dideu Medichem Co. Ltd 		58
SIMAGCHEM CORP 		58

View Lastest Price from Dexrazoxane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dexrazoxane pictures 2026-06-09 Dexrazoxane
24584-09-6
 1g 98%-102% 10KGS WUHAN FORTUNA CHEMICAL CO., LTD
Dexrazoxane pictures 2026-05-29 Dexrazoxane
24584-09-6
 1KG 99%, USP 5,000KG Hangzhou Hyper Chemicals Limited
Dexrazoxane pictures 2026-05-25 Dexrazoxane
24584-09-6
 $39.00-81.00 99.82% 10g TargetMol Chemicals Inc.
  • Dexrazoxane pictures
  • Dexrazoxane
    24584-09-6
  • $0.00
  • 98%-102%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Dexrazoxane pictures
  • Dexrazoxane
    24584-09-6
  • 99%, USP
  • Hangzhou Hyper Chemicals Limited
  • Dexrazoxane pictures
  • Dexrazoxane
    24584-09-6
  • $39.00-81.00
  • 99.82%
  • TargetMol Chemicals Inc.

Dexrazoxane Spectrum

Dexrazoxane(24584-09-6)1HNMR

24584-09-6(Dexrazoxane)Related Search:

Methyl acrylate Methylparaben Methyl acetate METSULFURON METHYL Bensulfuron methyl
Kresoxim-methyl 4,4'-propylenebis(piperazine-2,6-dione) N-(2-Amino-2-oxoethyl)-N-[(1S)-2-(3,5-dioxo-1-piperazinyl)-1-methylethyl]-glycine ICRF 198 N-(2-Amino-2-oxoethyl)-N-[(2S)-2-(3,5-dioxo-1-piperazinyl)propyl]-glycine
2,2',2'',2'''-[[(1S)-1-Methyl-1,2-ethanediyl]dinitrilo]tetrakisacetamide ICRF-186 (S)-(+)-1,2-Diaminopropane-N,N,N',N'-tetraacetic acid Glycine, N-(2-amino-2-oxoethyl)-N-[(2R)-2-(3,5-dioxo-1-piperazinyl)propyl]- Glycine, N-(2-amino-2-oxoethyl)-N-[2-(3,5-dioxo-1-piperazinyl)propyl]-
Dexrazoxane IMpurity D (N-oxide) Thiophanate-methyl Methyl

1of4

DEXRAZOXANE (s)-4,4'-(1-methyl-1,2-ethanediyl)bis-2,6-piperazinedione 4’-(1-methyl-1,2-ethanediyl)bis-6-piperazinedion(+)-4 4’-propylenedi-6-piperazinedion(+)-4 adr529 cardioxane DEXTRORAZOXANE (S)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane (S)-ICRF-187 [S,(+)]-4,4'-Propylenebis(2,6-piperazinedione) 4,4'-[(S)-1-Methyl-1,2-ethanediyl]bis(2,6-piperazinedione) 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dionehydrochloride 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione Dexrazoxane ((S)-Razoxane) 2,6-Piperazinedione,4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis- (+)-(S)-4,4′-Propylenedi-2,6-piperazinedione (S)-(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane Dexrazoxane (S)-4,4'-(1-Methyl-1,2-ethanediyl)bis-2,6-piperazinedione) Dexrazoxane, >=99% Ca rdioxane、Dextrazoxane、Eucardion、Zinecard ICRF-187;NSC-169780 Dexrazoxane (ICRF-187 Dexrazoxane> (+)-dexrazoxane Dexrazoxane Impurity Dexrazoxane (NSC-169780) Dextrozosan. - Dextropropimide Right razoxane Dexrazoxane 24584-09-6 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione 2,6-Piperazinedione, 4,4'-[(1S)-1-methyl-1,2-ethanediyl]bis- Dextropropimine (S)-4,4'-(propane-1,2-diyl)bis(piperazine-2,6-dione) Dexrazoxane, 10 mM in DMSO Dexrazoxane - Bio-X ? 4,4'-[(1S)-1-Methyl-1,2-ethanediyl]bis-2,6-piperazinedione DEXTRAZOXANE 24584-09-6 C11H16N4O4 API Chelating Agent 24584-09-6