PF-562271
- CAS No.
- 939791-38-5
- Chemical Name:
- PF-562271
- Synonyms
- PF-00562271, >=98%;PF-562271 (besylate);PF-00562271 Besylate;PF-562271 PhSO3H salt;PF-00562271 (PF-562271);PF-562271 benzenesulfonate;LKLWTLXTOVZFAE-UHFFFAOYSA-N;PF-562271 besylate PF562271;PF 562271 Benzenesulfonic acid;PF-562271 benzenesulfonate salt
- CBNumber:
- CB22535568
- Molecular Formula:
- C27H26F3N7O6S2
- Molecular Weight:
- 665.66
- MDL Number:
- MFCD14105612
- MOL File:
- 939791-38-5.mol
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| solubility | insoluble in EtOH; insoluble in H2O; ≥11.1 mg/mL in DMSO with gentle warming |
| form | solid |
| color | Off-white to light yellow |
| FDA UNII | FK2M84H8UI |
| UNSPSC Code | 41121800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c |
PF-562271 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18499 | PF-562271 (besylate) ≥98% | 939791-38-5 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 18499 | PF-562271 (besylate) ≥98% | 939791-38-5 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 18499 | PF-562271 (besylate) ≥98% | 939791-38-5 | 10mg | $266 | 2024-03-01 | Buy |
| Cayman Chemical | 18499 | PF-562271 (besylate) ≥98% | 939791-38-5 | 50mg | $775 | 2024-03-01 | Buy |
| TRC | P293925 | PF562271Besylate | 939791-38-5 | 100mg | $1040 | 2021-12-16 | Buy |
PF-562271 Chemical Properties,Uses,Production
Description
Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) are non-receptor tyrosine kinases that constitute the FAK subfamily and play a vital role in many oncogenic pathways. PF-562271 is an ATP-competitive, reversible inhibitor of FAK (IC50 = 1.5 nM) that demonstrates 10-fold reduced potency for PYK2 (IC50 = 14 nM) and >100-fold selectivity against other protein kinases. PF-562271 inhibits FAK phosphorylation with an EC50 value of 93 ng/ml in glioblastoma-bearing mice and has been shown to regress tumors in multiple xenograft models.
Uses
A potent, ATP-competitive and reversible inhibitor of FAK and Pyk2 catalytic activity with IC50s of 1.5 nM and 14 nM, respectively.
Uses
PF 562271 Besylate is the besylate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK).
in vivo
PF-562,271 (33 mg/kg, p.o.) inhibits FAK phosphorylation in tumors in a dose- and time-dependent manner in tumor-bearing mice. FAK phosphorylation inhibition relative to total blood concentration of PF-562,271 results in a calculated EC50 of 93 ng/mL. PF-562,271 (25 mg/kg, p.o.) induces apoptosis 2-fold greater in treated tumors compared with vehicle-treated control tumors on day 3[1]. PF-562,271 (33 mg/kg, p.o.) and dasatinib extensively inhibit the movement of tumor cells in the animals. Inhibition of FAK kinase activity following treatment with PF-562,271 results in altered E-cadherin dynamics in vivo[3].
target
FAK
References
[1]stokes jb, adair sj, slack-davis jk, walters dm, tilghman rw, hershey ed, lowrey b, thomas ks, bouton ah, hwang rf, stelow eb, parsons jt, bauer tw. inhibition of focal adhesion kinase by pf-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. mol cancer ther. 2011 nov;10(11):2135-45. doi: 10.1158/1535-7163.mct-11-0261. epub 2011 sep 8.
[2]roberts wg, ung e, whalen p, cooper b, hulford c, autry c, richter d, emerson e, lin j, kath j, coleman k, yao l, martinez-alsina l, lorenzen m, berliner m, luzzio m, patel n, schmitt e, lagreca s, jani j, wessel m, marr e, griffor m, vajdos f. antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, pf-562,271. cancer res. 2008 mar 15;68(6):1935-44. doi: 10.1158/0008-5472.can-07-5155.
PF-562271 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38663 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
View Lastest Price from PF-562271 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | PF-562271 besylate
939791-38-5
|
US $32.00-90.00 / mg | 99.5% | 10g | TargetMol Chemicals Inc. |
-
- PF-562271 besylate
939791-38-5
- US $32.00-90.00 / mg
- 99.5%
- TargetMol Chemicals Inc.
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