Droxinostat
- CAS No.
- 99873-43-5
- Chemical Name:
- Droxinostat
- Synonyms
- CS-425;NS 41080;Droxinostat;Droxinostat (NS41080);Droxinostat, 10 mM in DMSO;Droxinostat NS41080 NS-41080;4-(4-chloro-2-methylphenoxy)-N-hydroxybutylamide;4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide;4-(4-Chloro-2-methyl-phenoxy)-N-hydroxy-butyramide;ButanaMide, 4-(4-chloro-2-Methylphenoxy)-N-hydroxy-
- CBNumber:
- CB22537542
- Molecular Formula:
- C11H14ClNO3
- Molecular Weight:
- 243.69
- MDL Number:
- MFCD01326592
- MOL File:
- 99873-43-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Droxinostat price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23869 | Droxinostat ≥98% | 99873-43-5 | 1mg | $37 | 2026-04-30 | Buy |
| Cayman Chemical | 23869 | Droxinostat ≥98% | 99873-43-5 | 5mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 23869 | Droxinostat ≥98% | 99873-43-5 | 10mg | $158 | 2026-04-30 | Buy |
| Cayman Chemical | 23869 | Droxinostat ≥98% | 99873-43-5 | 25mg | $349 | 2026-04-30 | Buy |
| ChemScene | CS-0491 | Droxinostat 99.08% | 99873-43-5 | 5mg | $54 | 2026-06-04 | Buy |
Droxinostat Chemical Properties, Uses, Production
Uses
Droxinostat is a histone deacetylase selective inhibitor and is used in cancer therapy and cancer research. Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8.
Definition
ChEBI: 4-(4-chloro-2-methylphenoxy)-N-hydroxybutanamide is an aromatic ether.
Biological Activity
droxinostat is a selective inhibitor of hdac3, hdac6, and hdac8 with ic50 value of 16.9 ± 5.0 μm, 2.47 ± 1.09 μm, and 1.46 ± 0.11 μm, respectively [1].hdacs (histone deacetylases) are enzymes responsible of the deacetylation of lysine that residues of core histones and play a pivotal role in controlling chromatin remodeling and transcriptional activation. it is also reported that hdacs control the acetylation and activation status of multiple non-histone proteins, including the heat shock protein 90 (hsp90) which is an essential molecular chaperone for fungal virulence and antifungal resistance. multiple hdacs have been identified and hdac1 to hdac10 are shown to express in malignant cells which reminds the hdac inhibitor as a target for cancer therapy [2] [3].droxinostat is a selective hdac inhibitor and is different from the known pan-hdaci tsa which inhibits all tested hdac. when tested with prostate cancer line ppc-1 cells, droxinostat treatment selectively inhibited hdac3, hdac6, and hdac8 activity at the concentration of 50 μm/l which sensitized cells to death ligands [1]. in androgen-dependent cap cells, administration of droxinostat selectively inhibited hdacs and downregulated c-flp expression which resulted in cells apoptosis [4].
target
HDAC8
IC 50
HDAC8: 1.46 μM (IC50); HDAC6: 2.47 μM (IC50); HDAC3: 16.9 μM (IC50)
References
[1]. wood, t.e., et al., selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. mol cancer ther, 2010. 9(1): p. 246-56.
[2]. lamoth, f., p.r. juvvadi, and w.j. steinbach, histone deacetylase inhibition as an alternative strategy against invasive aspergillosis. front microbiol, 2015. 6: p. 96.
[3]. mackmull, m.t., et al., histone deacetylase inhibitors cause the selective depletion of bromodomain containing proteins. mol cell proteomics, 2015.
[4]. mccourt, c., et al., elevation of c-flip in castrate-resistant prostate cancer antagonizes therapeutic response to androgen receptor-targeted therapy. clin cancer res, 2012. 18(14): p. 3822-33.
Droxinostat Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2774 | 58 |
| ApexBio Technology LLC | +1-832-696-8203 | info@apexbt.com | United States | 477 | 60 |
View Latest Price from Droxinostat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-04 | Droxinostat
99873-43-5
|
$58.00-148.00 | 99.83% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-26 | Droxinostat
99873-43-5
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
-
- Droxinostat
99873-43-5
- $58.00-148.00
- 99.83%
- TargetMol Chemicals Inc.
-
- Droxinostat
99873-43-5
- $1.00
- 99%
- Career Henan Chemical Co
