ChemicalBook >> CAS DataBase List >>1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile structure

CAS No.: 350797-56-7

Chemical Name:: 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

Synonyms: SL-5;Silodosin Nitro Impurity;3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate;1-(3-Benzoyloxypropyl)-7-cyano-5-(2-nitropropyl) indoline.;1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-in...;3-[7-cyano-5-(2-nitropropyl)-2,3-dihydroindol-1-yl]propyl benzoate;3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate (Silodosin Impurity);1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile;1H-Indole-7-carbonitrile, 1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-

CBNumber:: CB22546472

Molecular Formula:: C22H23N3O4

Molecular Weight:: 393.44

MDL Number:: MFCD17169997

MOL File:: 350797-56-7.mol

MSDS File:: SDS

Last updated:2026-05-28 00:01:22

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1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Properties

Melting point	73-75°C
Boiling point	608.6±55.0 °C(Predicted)
Density	1.27
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	7.80±0.13(Predicted)
form	Solid
color	Light Yellow to Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-C982035-5G	3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate	350797-56-7	5g	$189	2026-06-03	Buy
TRC	TRC-C982035-25G	3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate	350797-56-7	25g	$726	2026-06-03	Buy
TRC	TRC-C982035-100G	3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate	350797-56-7	100g	$2128	2026-06-03	Buy
aablocks	AA0037AC	3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate 97%	350797-56-7	1g	$8	2026-05-28	Buy
aablocks	AA0037AC	3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate 97%	350797-56-7	5g	$30	2026-05-28	Buy

Product number	Packaging	Price	Buy
TRC-C982035-5G	5g	$189	Buy
TRC-C982035-25G	25g	$726	Buy
TRC-C982035-100G	100g	$2128	Buy
AA0037AC	1g	$8	Buy
AA0037AC	5g	$30	Buy

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Chemical Properties, Uses, Production

Uses

3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl Benzoate is used in the preparation of Silodosin (S465000), an α1a-adrenoceptor antagonist. It is used in treatment of benign prostatic hypertophy.

Synthesis

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde

350797-55-6

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile

350797-56-7

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde (20.0 g) was used as a starting material and dissolved in tetrahydrofuran (29.0 ml). To this solution, hydroxylamine hydrochloride (4.21 g) and pyridine (16.0 ml) were added sequentially. The reaction mixture was stirred at a constant temperature at 50 °C for 2 h. Acetic anhydride (9.0 ml) was subsequently added. Stirring of the reaction mixture was continued at 80°C for 2 hours. After completion of the reaction, extraction was carried out with toluene. The toluene layer obtained by extraction was washed with dilute hydrochloric acid, after which the solvent was removed by distillation under reduced pressure to give 16.0 g of propyl 3-(7-cyano-5-(2-nitropropyl)dihydroindol-1-yl)benzoate (Compound XX).

References

[1] Patent: WO2011/124704, 2011, A1. Location in patent: Page/Page column 19-20
[2] Patent: WO2013/56842, 2013, A1. Location in patent: Page/Page column 19
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 8, p. 3826 - 3839

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Preparation Products And Raw materials

Raw materials

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carboxaldehyde Hydroxylamine hydrochloride Tetrahydrofuran Pyridine Acetic anhydride

Preparation Products

5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile Silodosin

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Suppliers

Global Suppliers ( 103)

Supplier	Tel	Email	Country	ProdList	Advantage
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6741	52
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10244	55
Lihe Wuhan New Chemical Materials Co., Ltd.	027-88395709		China	427	50
Nanjing Chalf-Pharm Technology Co., Ltd.	025-57018978 18251899859	sales@chalf-pharm.com	China	5855	50
Intelligence Pharm Science(Shanghai) Co., Ltd.	021-57898186		China	448	55
Nanjing Abix Biochemical Technology Co., Ltd.	025-87193546 18652950785;	chemweiao@163.com	China	9009	60
Shanghai QianYan Bio-technology Co., Ltd	02781293128	orders@biochemsafebuy.com	China	9904	55
Cangzhou Enke Pharma-tech Co., Ltd.	0317-5296180 15533709196	enkepharma@126.com	China	2495	55

Supplier	Advantage
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
XiaoGan ShenYuan ChemPharm co,ltd	52
Bide Pharmatech Ltd.	60
Shanghai YuLue Chemical Co., Ltd.	55
Lihe Wuhan New Chemical Materials Co., Ltd.	50
Nanjing Chalf-Pharm Technology Co., Ltd.	50
Intelligence Pharm Science(Shanghai) Co., Ltd.	55
Nanjing Abix Biochemical Technology Co., Ltd.	60
Shanghai QianYan Bio-technology Co., Ltd	55
Cangzhou Enke Pharma-tech Co., Ltd.	55

View Latest Price from 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 350797-56-7		1kg	98%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-05-28	Silodosin 350797-56-7	$10.50	1KG	99%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD
2025-12-24	1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 350797-56-7		1KG	99.0%	1000Tons	Shaanxi Dideu Medichem Co. Ltd

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
350797-56-7
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

Silodosin
350797-56-7
$10.50
99%
Hebei Chuanghai Biotechnology Co,.LTD

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile
350797-56-7
$0.10
99.0%
Shaanxi Dideu Medichem Co. Ltd

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile Spectrum

1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile(350797-56-7)¹HNMR

350797-56-7 (1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile) Related Search:

Silodosin Impurity 18 Silodosin β-D-Glucuronide N-Carboxybenzyl O-Methyl Tri-acetate Silodosin Impurity 26 NCFJJNFEEPMRAQ-XMMPIXPASA-N Silodosin

5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate Silodosin 1H-Indole-7-carbonitrile, 2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]- O-Acetyl Silodosin 1-(3-Hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]aMino]propyl]-1H-indole-7-carboxaMide

Silodosin Carboxylic Acid Impurity (R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-1-(3-hydroxypropyl)indoline-7-carboxamide(WXG00186) Silodosin β-D-Glucuronide Sodium Salt Silodosin Glucuronide Silodosin-d4 (Chiral)

5-(2-Aminopropyl)-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile Silodosin Impurity 33 Silodosin-d6

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3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-indole-7-carbonitrile 3-[7-cyano-5-(2-nitropropyl)-2,3-dihydroindol-1-yl]propyl benzoate Silodosin Nitro Impurity 1H-Indole-7-carbonitrile, 1-[3-(benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)- 1-[3-(Benzoyloxy)propyl]-2,3-dihydro-5-(2-nitropropyl)-1H-in... 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate (Silodosin Impurity) 1-(3-Benzoyloxypropyl)-7-cyano-5-(2-nitropropyl) indoline. SL-5 350797-56-7