2-Chloro-5-(trifluoroMethoxy)pyridine
- CAS No.
- 1206972-45-3
- Chemical Name:
- 2-Chloro-5-(trifluoroMethoxy)pyridine
- Synonyms
- 2-Chloro-5-(trifluoromethoxy);2-Chloro-5-(trifluoroMethoxy)pyridine;Pyridine, 2-chloro-5-(trifluoromethoxy)-;2-Chloro-5-(trifluoromethoxy)pyridine 97%
- CBNumber:
- CB22550327
- Molecular Formula:
- C6H3ClF3NO
- Molecular Weight:
- 197.54
- MDL Number:
- MFCD18257007
- MOL File:
- 1206972-45-3.mol
- MSDS File:
- SDS
| Boiling point | 41-43 °C(Press: 15 Torr) |
|---|---|
| Density | 1.463±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -3.55±0.10(Predicted) |
| form | liquid |
| color | Colourless |
| InChI | InChI=1S/C6H3ClF3NO/c7-5-2-1-4(3-11-5)12-6(8,9)10/h1-3H |
| InChIKey | PONLSAHALFQCNY-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC=C(OC(F)(F)F)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P271-P260-P280 |
| HS Code | 2933399990 |
2-Chloro-5-(trifluoroMethoxy)pyridine price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | GYB97245 | 2-Chloro-5-(trifluoromethoxy)pyridine | 1206972-45-3 | 2.5g | $383.5 | 2026-06-04 | Buy |
| Apolloscientific | PC200445 | 2-Chloro-5-(trifluoromethoxy)pyridine 97% | 1206972-45-3 | 1g | $108 | 2026-06-04 | Buy |
| Apolloscientific | PC200445 | 2-Chloro-5-(trifluoromethoxy)pyridine 97% | 1206972-45-3 | 5g | $430 | 2026-06-04 | Buy |
| Apolloscientific | PC200445 | 2-Chloro-5-(trifluoromethoxy)pyridine 97% | 1206972-45-3 | 10g | $753 | 2026-06-04 | Buy |
| Apolloscientific | PC200445 | 2-Chloro-5-(trifluoromethoxy)pyridine 97% | 1206972-45-3 | 25g | $1503 | 2026-06-04 | Buy |
2-Chloro-5-(trifluoroMethoxy)pyridine Chemical Properties, Uses, Production
Synthesis
1221171-73-8
1206972-45-3
General procedure for the synthesis of 2-chloro-5-(trifluoromethoxy)pyridine (6) from 2-chloro-5-trichloromethoxypyridine (5,7.4 g, 30.0 mmol): 2-chloro-5-trichloromethoxypyridine (5) was added slowly and dropwise to a molten mixture of SbF3 (10.7 g, 60.0 mmol, 2.0 equiv) and SbCl5 (1.4 g, 0.6 mL, 4.6 mmol, 0.15 equiv) in a molten mixture. The reaction mixture was stirred at 120 °C to 150 °C for 3 h. The progress of the reaction was monitored by gas chromatography (GC) to confirm the complete conversion of the feedstock and the disappearance of the by-product OCF2Cl. Upon completion of the reaction, the mixture was cooled to 0 °C and dissolved in dichloromethane (100 mL). Subsequently, the reaction was quenched with saturated aqueous sodium bicarbonate solution (100 mL) and potassium fluoride solution (20%, 50 mL), and the aqueous layer was extracted with dichloromethane (2 x 50 mL). The organic layers were combined, dried with anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The crude product was purified by vacuum distillation to give 2-chloro-5-(trifluoromethoxy)pyridine (6,3.6 g, 18.0 mmol, 60% yield) as a colorless oil. The boiling point of the product was 41-43 °C/20 mbar.1H NMR (CDCl3, 300 MHz): δ=8.35 (s,1H), 7.55 (d,J=8.7Hz,1H), 7.41 (d,J=8.7Hz,1H).13C NMR (CDCl3, 75 MHz): δ=149.3,142.7,140.1, 131.3,125.1,120.2 (q,J=259Hz).MS (EI): m/z=197[M+],162[M+-Cl].
References
[1] Patent: WO2010/40461, 2010, A1. Location in patent: Page/Page column 19-20
[2] European Journal of Organic Chemistry, 2010, # 31, p. 6043 - 6066
[3] Patent: US2015/307465, 2015, A1. Location in patent: Paragraph 0630
2-Chloro-5-(trifluoroMethoxy)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Cochemical Ltd. | 029-86115547 17791676824 | sales@cochemical.com | China | 3014 | 58 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hubei Jusheng Technology Co.,Ltd | 027-59599241 18871490274 | 1400878000@qq.com | China | 9506 | 58 |
| Xi'an NewProChem Co.,Ltd. | 15332490153 | newprochem@126.com | China | 991 | 55 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
